Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof
    5.
    发明授权
    Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof 失效
    吡啶并嘧啶衍生物,其制备方法,治疗用途

    公开(公告)号:US07842806B2

    公开(公告)日:2010-11-30

    申请号:US12166431

    申请日:2008-07-02

    IPC分类号: C07D471/00

    CPC分类号: C07D471/04

    摘要: The disclosure relates to pyrido[2,3-d]pyrimidone compounds, to the preparation thereof and to the therapeutic use thereof, wherein said compounds are of general formula (I): in the form of a base or of an addition salt with an acid which is pharmaceutically acceptable, in the form of hydrates or of solvates, and also in the form of enantiomers, diastereoisomers and a mixture thereof. The disclosure also relates to processes for preparing said compounds, to pharmaceutical compositions containing a compound of general formula (I), and to the therapeutic use of said compounds and compositions.

    摘要翻译: 本公开涉及吡啶并[2,3-d]嘧啶酮化合物,其制备方法及其治疗用途,其中所述化合物为通式(I):以碱的形式或加成盐与 其为药学上可接受的,为水合物或溶剂化物形式,也为对映异构体,非对映异构体及其混合物的形式。 本公开还涉及制备所述化合物的方法,含有通式(I)化合物的药物组合物以及所述化合物和组合物的治疗用途。

    PYRIDO-PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
    6.
    发明申请
    PYRIDO-PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF 有权
    吡啶二吡啶衍生物,其制备方法及其治疗方法

    公开(公告)号:US20090233923A1

    公开(公告)日:2009-09-17

    申请号:US12415256

    申请日:2009-03-31

    CPC分类号: C07D471/04

    摘要: The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

    摘要翻译: 本公开涉及通式(I)的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用:及其酸加成盐,水合物和溶剂化物,以及对映异构体,非对映异构体和混合物的形式 其中。 本公开还涉及制备所述衍生物的方法,含有通式(I)的化合物的药物组合物及其治疗用途。

    Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
    7.
    发明授权
    Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics 失效
    吡啶并吲哚酮衍生物在3位被杂环基取代,其制备及其在治疗中的应用

    公开(公告)号:US07456193B2

    公开(公告)日:2008-11-25

    申请号:US11109121

    申请日:2005-04-19

    CPC分类号: C07D471/04

    摘要: The present invention relates to pyridoindolone derivatives substituted in the 3-position by a heterocyclic group of general formula (I): in which: R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 represents a hydrogen atom or a (C1-C4)alkyl group; R3 represents a thienyl mono- or polysubstituted by a methyl group; or a monocyclic or bicyclic heterocyclic radical chosen from: a pyridyl, an N-oxidopyridinio, a pyrazolyl, an (N-phenyl)pyrazolyl, an (N-halophenyl)pyrazolyl, a furyl, an indolyl, an (N-benzyl)indolyl, an (N-halobenzyl)indolyl, a benzothienyl or a benzofuryl, the said radicals being unsubstituted or substituted one or more times by a halogen atom or a methyl or methoxy group; R4 and R5 are identical or different and each independently represent a hydrogen or halogen atom or a hydroxyl, hydroxymethyl, (C1-C4)alkyl, trifluoromethyl, C1-C4)alkoxy, (C1-C4)alkoxycarbonyl or cyano group. Preparation process and application in therapeutics.

    摘要翻译: 本发明涉及通式(I)的杂环基在3-位上取代的吡啶并吲哚酮衍生物:其中:R 1表示氢原子或(C 1〜 (C 1 -C 4)烷基; R 2表示氢原子或(C 1 -C 4 -C 4)烷基; R 3表示被甲基单取代或多取代的噻吩基; 或选自以下的单环或双环杂环基:吡啶基,N-氧化吡啶基,吡唑基,(N-苯基)吡唑基,(N-卤代苯基)吡唑基,呋喃基,吲哚基,(N-苄基)吲哚基 ,(N-卤代苄基)吲哚基,苯并噻吩基或苯并呋喃基,所述基团是未取代的或被卤素原子或甲基或甲氧基取代一次或多次; R 4和R 5相同或不同,并且各自独立地表示氢或卤素原子或羟基,羟甲基,(C 1 -C 3 - (C 1 -C 4)烷基,三氟甲基,C 1 -C 4烷氧基,(C 1 -C 4 - 4)烷氧基羰基或氰基。 制剂工艺及其在治疗中的应用

    Tetrahydropyridines, preparation method and pharmaceutical compositions containing same
    9.
    发明授权
    Tetrahydropyridines, preparation method and pharmaceutical compositions containing same 失效
    四氢吡啶类,制备方法和含有它们的药物组合物

    公开(公告)号:US06689797B2

    公开(公告)日:2004-02-10

    申请号:US10169528

    申请日:2002-10-15

    IPC分类号: A61K3144

    CPC分类号: C07D405/06 C07D409/06

    摘要: The present invention relates to compounds of formula (I): in which R1 represents a hydrogen or halogen atom, or a group CF3; R2 and R3 represent, independently, a hydrogen atom or a methyl group; n and n′ each represent, independently, 0 or 1; * represents the positions of attachment; A represents N or CH; X represents a sulfur or oxygen atom; R4 and R5 represent, independently, a hydrogen atom or a (C1-C6) alkyl group; and also their salts or solvates, to a method for the preparation thereof and to the pharmaceutical compositions containing them.

    摘要翻译: 本发明涉及式(I)化合物:其中R 1表示氢或卤素原子或基团CF 3; R 2和R 3独立地表示氢原子或甲基; n和n'各自独立地表示, 0或1; *表示连接位置; A表示N或CH; X表示硫或氧原子; R4和R5独立地表示氢原子或(C1-C6)烷基;以及它们的盐或 溶剂合物,其制备方法和含有它们的药物组合物。