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公开(公告)号:US09126939B2
公开(公告)日:2015-09-08
申请号:US13806339
申请日:2011-06-24
申请人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号: A61K31/445 , C07D211/60 , C07D401/14 , C07D413/14 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/10 , C07D413/12 , C07D405/12
CPC分类号: C07D211/60 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D413/14
摘要: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译: 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物,用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号:US20130172347A1
公开(公告)日:2013-07-04
申请号:US13806339
申请日:2011-06-24
申请人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号: C07D211/60 , C07D401/10 , C07D405/12 , C07D401/06 , C07D401/12
CPC分类号: C07D211/60 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D413/14
摘要: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译: 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物,用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号:US08445515B2
公开(公告)日:2013-05-21
申请号:US12643229
申请日:2009-12-21
申请人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号: A61K31/445 , C07D401/06 , C07D413/12 , C07D211/36
CPC分类号: A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译: 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物,用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号:US20100160320A1
公开(公告)日:2010-06-24
申请号:US12643229
申请日:2009-12-21
申请人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号: A61K31/445 , C07D211/36 , C07D401/06 , C07D413/12 , A61K31/4545 , A61K31/5377 , A61P37/00 , A61P9/00 , A61P25/00
CPC分类号: A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译: 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物,用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号:US20100311753A1
公开(公告)日:2010-12-09
申请号:US12823039
申请日:2010-06-24
申请人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号: A61K31/5377 , C07D211/32 , C07D401/06 , C07D401/12 , C07D413/14 , A61K31/451 , A61K31/4545 , A61K31/454 , A61P9/00 , A61P9/10 , A61P7/02 , A61P25/00 , A61P37/00 , A61P29/00 , A61P3/10 , A61P25/28
CPC分类号: A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号:US20110275639A1
公开(公告)日:2011-11-10
申请号:US13072616
申请日:2011-03-25
申请人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
发明人: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号: A61K31/445 , C07D401/06 , C07D401/12 , C07D413/14 , A61K31/4545 , A61K31/454 , A61K31/5377 , A61P29/00 , A61P7/00 , A61P31/00 , A61P25/28 , A61P1/00 , A61P27/02 , A61P11/00 , A61P19/02 , A61P17/00 , A61P9/10 , A61P37/06 , A61P35/00 , A61P9/00 , A61P25/00 , A61P37/00 , A61P19/04 , A61P17/06 , A61P11/06 , A61P3/10 , C07D211/60
CPC分类号: A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译: 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物,用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号:US20110033241A1
公开(公告)日:2011-02-10
申请号:US12988799
申请日:2009-04-16
CPC分类号: E02B3/106 , B63B2231/76 , E02B7/02 , E02B17/028 , Y02A10/13
摘要: A dam construction method utilizing refrigerating technology is provided, the method takes natural water as the material to construct the dam and constructs an ice dam body by utilizing the refrigerating technology. The method includes the following steps: choosing the forms and quantity of ice unit bodies, determining the positions and quantity of frozen contact points, manufacturing sufficient ice unit bodies by frozen units, choosing heat insulating material with high performance as the heat preservation layer to cover on the outside of the frozen ice unit bodies; temporarily fixing the ice unit bodies; quickly freezing the seams of the ice unit bodies to form a whole ice dam; mounting temporary generating equipment and completing the temporary dam body; thawing the ice dam body after a permanent dam body is completed.
摘要翻译: 提出利用制冷技术的大坝施工方法,以天然水为材料建设坝体,利用制冷技术构建冰坝体。 该方法包括以下步骤:选择冰单位体的形式和数量,确定冻结接触点的位置和数量,通过冷冻机组制造足够的冰机体,选择高性能隔热材料作为保温层,以覆盖 在冷冻冰机身外面; 暂时固定冰机体; 迅速冻结冰单位身体的接缝,形成一个整个冰坝; 安装临时发电设备,完成临时坝体; 永久性水坝体完成后,解冻冰坝体。
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公开(公告)号:US09435092B2
公开(公告)日:2016-09-06
申请号:US12988799
申请日:2009-04-16
CPC分类号: E02B3/106 , B63B2231/76 , E02B7/02 , E02B17/028 , Y02A10/13
摘要: A dam construction method utilizing refrigerating technology is provided, the method takes natural water as the material to construct the dam and constructs an ice dam body by utilizing the refrigerating technology. The method includes the following steps: choosing the forms and quantity of ice unit bodies, determining the positions and quantity of frozen contact points, manufacturing sufficient ice unit bodies by frozen units, choosing heat insulating material with high performance as the heat preservation layer to cover on the outside of the frozen ice unit bodies; temporarily fixing the ice unit bodies; quickly freezing the seams of the ice unit bodies to form a whole ice dam; mounting temporary generating equipment and completing the temporary dam body; thawing the ice dam body after a permanent dam body is completed.
摘要翻译: 提出利用制冷技术的大坝施工方法,以天然水为材料建设坝体,利用制冷技术构建冰坝体。 该方法包括以下步骤:选择冰单位体的形式和数量,确定冻结接触点的位置和数量,通过冷冻机组制造足够的冰机体,选择高性能隔热材料作为保温层,以覆盖 在冷冻冰机身外面; 暂时固定冰机体; 迅速冻结冰单位身体的接缝,形成一个整个冰坝; 安装临时发电设备,完成临时坝体; 永久性水坝体完成后,解冻冰坝体。
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