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公开(公告)号：US10227357B2
公开(公告)日：2019-03-12
申请号：US14019442
申请日：2013-09-05
Applicant: Plexxikon Inc.
Inventor： Jack Lin , John Buell , Katrina Chan , Todd Ewing , Prabha Ibrahim , Marika Nespi , Phuongly Pham , Songyuan Shi , Wayne Spevak , Guoxian Wu , Jiazhong Zhang , Ying Zhang
IPC: C07D495/04 , A61K31/519 , C07D401/12 , A61K31/52 , C07D239/74 , A61K31/5377 , C07D491/056 , C07D473/00 , C07D487/04 , A61K31/517 , C07D519/00
Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.
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公开(公告)号：US20170056382A1
公开(公告)日：2017-03-02
申请号：US15260042
申请日：2016-09-08
Applicant: Plexxikon Inc.
Inventor： Guoxian Wu , Jiazhong Zhang , Yong-Liang Zhu , Chao Zhang , Prabha N. Ibrahim , Songyuan Shi , Wayne Spevak , Dean R. Artis , James Tsai
IPC: A61K31/44 , A61K31/505 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/437 , A61K31/47 , A61K31/42 , A61K31/415 , A61K31/433 , A61K31/549 , A61K31/4436 , A61K31/4439
CPC classification number: A61K31/44 , A61K31/415 , A61K31/42 , A61K31/433 , A61K31/437 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/82 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/38 , C07D231/40 , C07D239/48 , C07D239/49 , C07D261/14 , C07D263/48 , C07D285/135 , C07D285/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , A61K31/4427 , A61K2300/00
Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Abstract translation: 描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
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公开(公告)号：US20140303187A1
公开(公告)日：2014-10-09
申请号：US14245770
申请日：2014-04-04
Applicant: Plexxikon Inc.
Inventor： Guoxian Wu , Jiazhong Zhang , Chao Zhang , Prabha N. Ibrahim , Songyuan Shi , Wayne Spevak , James Tsai
IPC: C07D417/04 , A61K31/506
CPC classification number: A61K31/44 , A61K31/415 , A61K31/42 , A61K31/433 , A61K31/437 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/82 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/38 , C07D231/40 , C07D239/48 , C07D239/49 , C07D261/14 , C07D263/48 , C07D285/135 , C07D285/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , A61K31/4427 , A61K2300/00
Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
Abstract translation: 描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
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公开(公告)号：US20130237531A1
公开(公告)日：2013-09-12
申请号：US13866353
申请日：2013-04-19
Applicant: PLEXXIKON INC.
Inventor： Guoxian Wu , Jiazhong Zhang , Chao Zhang , Prabha N. Ibrahim , Songyuan Shi , Wayne Spevak , James Tsai
IPC: C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/47 , A61K31/444 , A61K45/06 , A61K31/42 , C07D285/16 , C07D215/14 , C07D213/82 , C07D261/14 , A61K31/549 , A61K31/44
CPC classification number: A61K31/44 , A61K31/415 , A61K31/42 , A61K31/433 , A61K31/437 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/82 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/38 , C07D231/40 , C07D239/48 , C07D239/49 , C07D261/14 , C07D263/48 , C07D285/135 , C07D285/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , A61K31/4427 , A61K2300/00
Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：US20230277534A1
公开(公告)日：2023-09-07
申请号：US17895972
申请日：2022-08-25
Applicant: Plexxikon Inc.
Inventor： Prabha N. Ibrahim , Chao Zhang , Wayne Spevak , Jiazhong Zhang , Guoxian Wu , Jack Lin , Hanna Cho , Marika Nespi , Songyuan Shi , Todd Ewing , Ying Zhang
IPC: A61K31/506 , C07D471/04 , A61K31/437 , A61K31/5377
CPC classification number: A61K31/506 , C07D471/04 , A61K31/437 , A61K31/5377
Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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Patent Agency Ranking
公开(公告)号：US20230081426A1
公开(公告)日：2023-03-16
申请号：US17480111
申请日：2021-09-20
Applicant: Plexxikon Inc.
Inventor： Jiazhong Zhang , John Buell , Phuongly Pham , Wayne Spevak , Mark Vander Wal , Xinping Han , Chao Zhang , Zuojun Guo , Jack Walleshauser , Ying Zhang , Steven Rank , Yasuyuki Ogawa , Songyuan Shi
IPC: A61K31/517 , C07D487/08 , C07D519/00 , A61K31/5377 , A61K31/5386 , C07D498/08 , A61K31/551
Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein: R1, R2, R3, X, and Z are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
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公开(公告)号：US11337976B2
公开(公告)日：2022-05-24
申请号：US15435569
申请日：2017-02-17
Applicant: Plexxikon Inc.
Inventor： Prabha N. Ibrahim , Chao Zhang , Wayne Spevak , Jiazhong Zhang , Guoxian Wu , Jack Lin , Hanna Cho , Marika Nespi , Songyuan Shi , Todd Ewing , Ying Zhang
IPC: A61K31/506 , A61K31/437 , A61K31/5377 , C07D471/04
Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：US10647716B2
公开(公告)日：2020-05-12
申请号：US16441610
申请日：2019-06-14
Applicant: Plexxikon Inc.
Inventor： Prabha N. Ibrahim , Wayne Spevak , Jiazhong Zhang , Songyuan Shi , Ben Powell , Yan Ma
IPC: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377
Abstract: Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.
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公开(公告)号：US10160747B2
公开(公告)日：2018-12-25
申请号：US15460095
申请日：2017-03-15
Applicant: Plexxikon Inc.
Inventor： Jack Lin , Prabha N. Ibrahim , Aaron Albers , John Buell , Zuojun Guo , Phuongly Pham , Hannah Powers , Songyuan Shi , Wayne Spevak , Guoxian Wu , Jiazhong Zhang , Ying Zhang , Jeffrey Wu
IPC: A61K31/506 , C07D401/14 , A61K31/437 , A61K31/444 , A61K31/4985 , A61K31/5355 , A61K45/06 , C07D401/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D417/04
Abstract: Disclosed are compounds of Formula I(b): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Ring A, Ring HD, J, each T, R3, R4, R5, each R7, and m are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
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公开(公告)号：US09814714B2
公开(公告)日：2017-11-14
申请号：US15160729
申请日：2016-05-20
Applicant: Plexxikon Inc.
Inventor： Prabha N. Ibrahim , Chao Zhang , Wayne Spevak , Jiazhong Zhang , Guoxian Wu , Jack Lin , Hanna Cho , Marika Nespi , Songyuan Shi , Todd Ewing , Ying Zhang , Gideon Bollag
IPC: C07D239/42 , A61K31/506 , A61K45/06 , A61K31/519
CPC classification number: A61K31/506 , A61K31/519 , A61K45/06
Abstract: The present disclosure provides methods of treating a subject suffering from or at risk of a BRAF V600 mutation or BRAF fusion mutation related disease or condition, without activating the MAPK pathway or inducing expression of MAPK pathway genes in cells harboring wild-type BRAF.
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