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1.发明授权Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies 失效粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）中和抗体公开(公告)号：US08609101B2
公开(公告)日：2013-12-17
申请号：US12766444
申请日：2010-04-23
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/243 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/403 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The invention provides a GM-CSF neutralizing human monoclonal antibody, 1783J22, as well as methods of making and use thereof. The monoclonal antibody is further characterized by its ability to bind epitopes from GM-CSF proteins of multiple species.
摘要翻译： 本发明提供GM-CSF中和人单克隆抗体1783J22，以及其制备和使用方法。 单克隆抗体的特征还在于其能够结合来自多种物种的GM-CSF蛋白的表位。
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2.发明申请Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Neutralizing Antibodies 失效粒细胞巨噬细胞集落刺激因子（GM-CSF）中和抗体公开(公告)号：US20100291075A1
公开(公告)日：2010-11-18
申请号：US12766444
申请日：2010-04-23
IPC分类号： A61K39/385 , C07K16/24 , C12N15/63 , C12N5/10 , A61K39/00 , A61P35/00 , A61P35/02 , A61P31/14 , A61P31/16 , A61P31/22 , A61P31/18 , A61P31/04 , A61P31/08 , A61P31/20 , A61P37/04 , A61P37/02 , A61P29/00 , A61P25/28 , A61P3/10 , A61P11/06 , A61P11/00
CPC分类号： C07K16/243 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/403 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The invention provides a GM-CSF neutralizing human monoclonal antibody, 1783J22, as well as methods of making and use thereof. The monoclonal antibody is further characterized by its ability to bind epitopes from GM-CSF proteins of multiple species.
摘要翻译： 本发明提供GM-CSF中和人单克隆抗体1783J22，以及其制备和使用方法。 单克隆抗体的特征还在于其能够结合来自多种物种的GM-CSF蛋白的表位。
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3.发明授权Monoclonal antibodies directed against trimeric forms of the HIV-1 envelope glycoprotein with broad and potent neutralizing activity 有权针对三聚体形式的HIV-1包膜糖蛋白的单克隆抗体具有广泛和有效的中和活性公开(公告)号：US09051362B2
公开(公告)日：2015-06-09
申请号：US12726245
申请日：2010-03-17
申请人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以对多种HIV-1物质进行中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US20140205612A1
公开(公告)日：2014-07-24
申请号：US13780776
申请日：2013-02-28
申请人： Po-Ying Chan-Hui , Katherine Doores , Michael Huber , Stephen Kaminsky , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Katherine Doores , Michael Huber , Stephen Kaminsky , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
CPC分类号： C07K16/1063 , A61K39/21 , A61K2039/505 , C07K16/1045 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供了一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以抵抗多种HIV-1物种的中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得到的单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染的能力。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US20110044994A1
公开(公告)日：2011-02-24
申请号：US12726245
申请日：2010-03-17
申请人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
IPC分类号： A61K39/42 , C07K16/10 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K39/395 , A61K39/21 , A61P31/18
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供了一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以抵抗多种HIV-1物质的中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US20060204328A1
公开(公告)日：2006-09-14
申请号：US11374264
申请日：2006-03-13
申请人： Steven Frey
发明人： Steven Frey
IPC分类号： E01F9/00
摘要： An improved highway barricade light, with increased visibility and operational life span that can be installed on a common traffic channelizer, without preventing the stacking of the channelizer. A base with hand-hold features is attached to the top of a traffic channelizer. The base holds a rechargeable power supply, control circuitry, switch, solar cell and a photoresistor. A reflector ring attaches to the base and holds an array of light emitting diodes (LED) circumferentially around the device. The LED's can be controlled to create a variety of flashing patterns to direct motorists, including, but not limited to, constant burn, flashing, clockwise, counter-clockwise, upward, downward and random. A transparent or translucent cover attaches to the base to protect the components, and may be flat, conical or dome shaped.
摘要翻译： 改进的高速公路路障灯，具有更高的可见性和使用寿命，可以安装在公共的通道信道器上，而不会妨碍信道化器的堆叠。 带有手持功能的基座连接到流量通道器的顶部。 基座装有可充电电源，控制电路，开关，太阳能电池和光敏电阻。 反射器环附接到基座并且围绕器件周向地保持发光二极管（LED）阵列。 可以控制LED以产生各种闪烁图案以引导驾驶者，包括但不限于恒定燃烧，闪烁，顺时针，逆时针，向上，向下和随机。 透明或半透明的盖子附接到基座以保护部件，并且可以是平的，圆锥形或圆顶形的。
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