摘要:
The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要:
Embodiments of the present invention are directed to methods and a mechanism for manipulating images generated by radiotherapy machines used in radiation diagnostic and treatment applications. In one embodiment, a method is provided for intelligent automatic propagation of real-time alterations across graphical structures of an image by mapping the relativity between the structures; determining the correlation between the structures and a manually edited structure; referencing a deformation map that maps a correspondence for each point in the original structure with a point in the edited structure and applying a similar relative change throughout the remaining structures in the image.
摘要:
Gesture based control of objects displayed on touch screen displays is described. An object is displayed on a touch screen display, and a first touch operation is detected at a first position on the display. The first position is within an area that is associated with the displayed object. A second touch operation is detected within the area. After detecting the first and second touch operations another, a third touch operation is detected at a third position. A distance between the third position and the first position is calculated. When the distance is greater than a predetermined value, a copy of the object is displayed on the touch screen display.
摘要:
An anchoring clip system that includes an anchoring clip that has a top flange portion and a base flange that can be connect to a substructure, and a cap member designed to be inserted over a portion of the roof panels so as to secure the roof panels to the anchoring clip. The anchoring clip system can optionally be designed to allow for fluid flow through or on one or more components of the anchoring clip system. The anchoring clip system can optionally include a locking crown that improves the wind uplift resistance of the panels.
摘要:
A hydrodynamic retarder having a first blade wheel and a second blade wheel concentric thereto, forming a hydrodynamic circuit grouped about a common rotary axis. Each blade wheel includes a base body and a blade arrangement fixed thereto including a plurality of blades each connected to receptacles in the base body. A first ring segment of at least one blade wheel includes at least one first blade having a flow edge facing the other blade wheel in each case, said edge having at least one extension running in a substantially straight line between the radial outer end thereof and the radial inner end thereof, and at least one second blade is provided in a second ring segment of the blade wheel, the blade having a retraction both opposite the flow edge facing the other blade wheel in each case, and opposite a protrusion protruding in the direction of the other blade wheel.
摘要:
Methods and apparatus for easily creating playlists of media programs to be played sequentially, where each program on a playlist either is played in real time, i.e., when broadcast, or is played time-shifted when the program temporally conflicts with one or more other programs on the playlist. When a playlist is played, a user can pause viewing at any time, in which case the methods and apparatus recompute the program sequence of the playlist and schedules program recordings as required.
摘要:
A locking system, in particular a locking system for aircraft landing gears. A space-saving, simple construction and little maintenance requirement of the locking system is achieved by at least one electromechanical drive unit, whose torque is transmitted to a drive shaft with a cam disk via axle-crossing transmitting. With the torque, the cam disk can move the locking system from the locked into the unlocked condition.
摘要:
A roofing system formed of a plurality of support members secured to a load bearing roof deck. A plurality of roofing panels are positioned on the support members and are oriented to form overlapping joints between the panels. Sealant is positioned within the overlapping joints of the panels. A compression bar is positioned over the overlapping joints and is secured to the overlapping joints and support member by a fastener arrangement.
摘要:
A microprocessor has a control unit with a housing surrounding the control unit. The invention also relates to a chip card having such a microprocessor that is protected against manipulations. At least one sensor indicates ambient states and is connected to the control unit and is provided in a region of the housing of the microprocessor. The control unit is configured in such a way that it can be placed in an inactive state if a measurement signal that indicates a predetermined ambient state is and/or is not fed to the control unit from the sensor.