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公开(公告)号：US06613745B1
公开(公告)日：2003-09-02
申请号：US09530799
申请日：2000-07-26
申请人： Ponnampalam Gopalakrishnakone , Xiao Chun Pu , Peter Tsun-Hon Wong , Mathew Choon Eng Gwee , R. Manjunatha Kini
发明人： Ponnampalam Gopalakrishnakone , Xiao Chun Pu , Peter Tsun-Hon Wong , Mathew Choon Eng Gwee , R. Manjunatha Kini
IPC分类号： A61K3800
摘要： The present invention relates generally to peptide molecules and to derivatives, homologues, analogues and mimetics thereof capable of inducing or facilitating analgesia or partial analgesia alone or in combination with other analgesic molecules. The present invention also contemplates a method of inducing or facilitating analgesia or partial analgesia by the administration of a peptide or a derivative, homologue, analogue or mimetic thereof. The amino acid sequence of the peptide molecules of the present invention are derived from or based on amino acid sequences of snake venom toxins, and, in particular, &agr;-neurotoxins.
摘要翻译： 本发明一般涉及能够诱导或促进单独镇痛或部分止痛或与其它止痛分子组合的衍生物，同系物，类似物和模拟物。 本发明还考虑通过给予肽或其衍生物，同系物，类似物或模拟物诱导或促进镇痛或部分镇痛的方法。 本发明的肽分子的氨基酸序列衍生自或基于蛇毒毒素，特别是α-神经毒素的氨基酸序列。
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公开(公告)号：US5965698A
公开(公告)日：1999-10-12
申请号：US532818
申请日：1996-05-03
IPC分类号： A61K38/00 , C07K1/00 , C07K1/107 , C07K14/75 , A61K38/04 , A61K38/10 , A61K38/16 , A61K38/36
CPC分类号： C07K1/00 , C07K1/1075 , C07K14/75 , A61K38/00
摘要： Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
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公开(公告)号：US5948887A
公开(公告)日：1999-09-07
申请号：US933402
申请日：1997-09-19
CPC分类号： C07K14/70 , C07K1/00 , C07K1/1075 , C07K14/75 , A61K38/00
摘要： Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
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4.发明授权Small peptides having anti-angiogenic and endothelial cell inhibition activity 有权具有抗血管生成和内皮细胞抑制活性的小肽公开(公告)号：US07317003B2
公开(公告)日：2008-01-08
申请号：US09766412
申请日：2001-01-22
申请人： Ruowen Ge , R. Manjunatha Kini
发明人： Ruowen Ge , R. Manjunatha Kini
CPC分类号： C07K14/52 , A61K38/00 , C12N9/6435 , C12Y304/21007
摘要： The present invention provides peptides having potent anti-angiogenic activity and endothelial cell proliferation inhibition activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.
摘要翻译： 本发明提供具有有效的抗血管生成活性和内皮细胞增殖抑制活性的肽。 肽可以作为用于预防或治疗不需要的血管发生的药物组合物施用，例如用于预防肿瘤转移或抑制原发性肿瘤生长。
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公开(公告)号：US6111069A
公开(公告)日：2000-08-29
申请号：US933843
申请日：1997-09-19
IPC分类号： A61K38/00 , C07K1/00 , C07K1/107 , C07K14/70 , C07K14/75 , C07K7/06 , A61K38/04 , A61K37/02 , C07K3/08
CPC分类号： C07K14/70 , C07K1/00 , C07K1/1075 , C07K14/75 , A61K38/00
摘要： Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
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公开(公告)号：US5928896A
公开(公告)日：1999-07-27
申请号：US934222
申请日：1997-09-19
CPC分类号： C07K1/00 , C07K1/1075 , C07K14/75 , A61K38/00
摘要： Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
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公开(公告)号：US20130183237A1
公开(公告)日：2013-07-18
申请号：US12665256
申请日：2008-06-18
摘要： The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites.
摘要翻译： 本发明涉及来自血液节肢动物唾液腺的凝血酶抑制剂，特别涉及通过在两个或三个不同位点与凝血酶相互作用的二价和三价凝血酶抑制剂。
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公开(公告)号：US20120135931A1
公开(公告)日：2012-05-31
申请号：US13319051
申请日：2010-05-05
IPC分类号： A61K38/58 , C07K14/815 , C07K7/06 , C07K14/81 , C12N1/21 , C12N1/19 , C12N5/10 , C12N15/15 , C12N15/113 , C12N15/63 , A61K38/57 , A61P7/00 , A61K38/08 , A61K38/10 , C07K1/107 , C07K7/08
CPC分类号： C07K14/811
摘要： The present invention relates to a method of modifying serine protease inhibitors in order to acquire or enhance any one of a variety of desired properties, including extent of inhibition, maintenance of inhibition following cleavage of the serine protease inhibitor by the target serine protease, speed of binding to the serine protease, neutralisation, and binding affinity. The present invention also relates to the products of such modifications and the uses of such products, in particular, their use in therapy.
摘要翻译： 本发明涉及一种修饰丝氨酸蛋白酶抑制剂的方法，以获得或增强各种所需性质中的任何一种，包括抑制程度，维持丝氨酸蛋白酶抑制剂被靶丝氨酸蛋白酶切割后的抑制作用 与丝氨酸蛋白酶结合，中和和结合亲和力。 本发明还涉及这些修饰的产品和这些产品的用途，特别是它们在治疗中的用途。
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9.发明授权Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site 失效多肽包括构象约束组，其侧翼于蛋白质 - 蛋白质相互作用位点公开(公告)号：US06258550B1
公开(公告)日：2001-07-10
申请号：US09413492
申请日：1999-10-06
IPC分类号： G01N3353
CPC分类号： C07K1/1075 , A61K38/00 , C07K1/00 , C07K14/75
摘要： Among other things, methods of obtaining putative protein-protein interaction sites of biologically-active polypeptides are provided. The methods include searching the polypeptides for a regions that are flanked on each termini by at least one proline residue; and isolating or producing the flanked regions.
摘要翻译： 提供了获得生物活性多肽的推定蛋白质 - 蛋白质相互作用位点的方法。 所述方法包括：通过至少一个脯氨酸残基搜索在每个末端侧翼的区域的多肽; 并分离或产生侧翼区。
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公开(公告)号：US06200954B1
公开(公告)日：2001-03-13
申请号：US09385442
申请日：1999-08-30
申请人： Ruowen Ge , R. Manjunatha Kini
发明人： Ruowen Ge , R. Manjunatha Kini
IPC分类号： A61K3800
CPC分类号： C12N9/6435 , A61K38/00 , C07K14/52 , C12Y304/21007
摘要： The present invention provides peptides having potent anti-angiogenic activity. The peptides can be administered as pharmaceutical compositions for prevention or treatment of undesired angiogenesis, for instance for prevention of tumor metastasis or inhibition of primary tumor growth.
摘要翻译： 本发明提供具有有效的抗血管生成活性的肽。 肽可以作为用于预防或治疗不需要的血管发生的药物组合物施用，例如用于预防肿瘤转移或抑制原发性肿瘤生长。
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