公开(公告)号：US20050119261A1

公开(公告)日：2005-06-02

申请号：US10799230

申请日：2004-03-12

申请人： Prasun Chakravarty ,  Michael Fisher ,  Jeffrey Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

发明人： Prasun Chakravarty ,  Michael Fisher ,  Jeffrey Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

IPC分类号： A61K31/4196 ,  A61P25/00 ,  C07D249/08 ,  C07D249/10 ,  C07D413/02 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D417/02 ,  C07D43/02

CPC分类号： C07D249/08 ,  C07D249/10

摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

摘要翻译： 由式I，II或III表示的二芳基取代的三唑化合物或其药学上可接受的盐，以及其制备方法。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相 包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

公开(公告)号：US20060183897A1

公开(公告)日：2006-08-17

申请号：US10549790

申请日：2004-03-12

申请人： Prasun Chakravarty ,  Michael Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

发明人： Prasun Chakravarty ,  Michael Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

IPC分类号： C07D417/02 ,  C07D403/02 ,  C07D413/02

CPC分类号： C07D249/08 ,  C07D249/10

摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

公开(公告)号：US20120115877A1

公开(公告)日：2012-05-10

申请号：US13214177

申请日：2011-08-20

申请人： Richard W. Scott ,  Dylan Clements ,  Yongjiang Xu ,  Haizhong Tang ,  Carol Mulrooney ,  Ehab Khalil ,  Damian Weaver ,  Xiaodong Fan

发明人： Richard W. Scott ,  Dylan Clements ,  Yongjiang Xu ,  Haizhong Tang ,  Carol Mulrooney ,  Ehab Khalil ,  Damian Weaver ,  Xiaodong Fan

IPC分类号： A61K31/496 ,  A61K31/4025 ,  A61P35/00 ,  A61K31/343 ,  A61P35/02 ,  A61K31/505 ,  A61K31/381

CPC分类号： A61K31/16 ,  A61K31/17 ,  A61K31/34 ,  A61K31/38

摘要： The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans.

摘要翻译： 本发明公开了表面两亲化合物的组合物及其用于治疗或减少动物如人类的癌症的方法。