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58 条记录 (耗时 0.038 秒)

    Substituted piperizines for the treatment of pain
    7.
    发明申请
    Substituted piperizines for the treatment of pain 审中-公开
    替代哌嗪治疗疼痛

    公开(公告)号：US20080139578A1

    公开(公告)日：2008-06-12

    申请号：US11982879

    申请日：2007-11-06

    申请人： Catherine Abbadie ,  Prasun K. Chakravarty ,  Joseph L. Duffy

    发明人： Catherine Abbadie ,  Prasun K. Chakravarty ,  Joseph L. Duffy

    IPC分类号： A61K31/495 ,  A61P29/00

    CPC分类号： A61K31/495

    摘要： The present invention is directed to the use of substituted piperizine compounds represented by Formula I, for the treatment of pain, including acute pain, chronic pain, cancer pain, visceral pain, inflammatory pain, neuropathic pain, post-herpetic neuralgia, diabetic neuropathy, trigeminal neuralgia, migraine, and fibromyalgia.

    摘要翻译： 本发明涉及式I代表的取代的哌嗪类化合物在治疗疼痛方面的应用，包括急性疼痛，慢性疼痛，癌症疼痛，内脏痛，炎性疼痛，神经性疼痛，疱疹后神经痛，糖尿病性神经病变， 三叉神经痛，偏头痛和纤维肌痛。

    SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    8.
    发明申请
    SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS 审中-公开
    取代的ARYL SULFONE衍生物作为钙通道阻断剂

    公开(公告)号：US20110172236A1

    公开(公告)日：2011-07-14

    申请号：US13119243

    申请日：2009-09-21

    申请人： Prasun K. Chakravarty ,  Joseph L. Duffy ,  Pengcheng Patric Shao

    发明人： Prasun K. Chakravarty ,  Joseph L. Duffy ,  Pengcheng Patric Shao

    IPC分类号： A61K31/498 ,  C07D211/40 ,  A61K31/45 ,  C07D401/04 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  C07D401/10 ,  C07D207/27 ,  A61K31/4015 ,  C07D417/04 ,  A61K31/433 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08

    CPC分类号： C07D215/06

    摘要： A series of substituted aryl sulfone derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, calcium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, diabetic neuropathy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, sleep disorder, bipolar disorder and stroke, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds.

    摘要翻译： 一系列由式I表示的取代的芳基砜衍生物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钙通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，尿失禁，瘙痒，过敏性皮炎，癫痫，糖尿病性神经病，肠易激综合征 综合征，抑郁症，焦虑症，多发性硬化症，睡眠障碍，双相性精神障碍和中风，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。

    Biaryl Substituted Pyrazinones as Sodium Channel Blockers
    9.
    发明申请
    Biaryl Substituted Pyrazinones as Sodium Channel Blockers 审中-公开
    二芳基取代的吡嗪酮作为钠通道阻断剂

    公开(公告)号：US20080280873A1

    公开(公告)日：2008-11-13

    申请号：US10594367

    申请日：2005-03-25

    申请人： Jun Liang ,  Prasun K. Chakravarty ,  Deborah E. Pan ,  William H. Parsons ,  Pengcheng P. Shao ,  Feng Yee ,  Bishan Zhou

    发明人： Jun Liang ,  Prasun K. Chakravarty ,  Deborah E. Pan ,  William H. Parsons ,  Pengcheng P. Shao ,  Feng Yee ,  Bishan Zhou

    IPC分类号： A61K31/4965 ,  C07D241/24

    CPC分类号： C07D241/24 ,  B05B1/02 ,  B05B1/14 ,  B05B1/34 ,  B65D83/20 ,  C07D241/18 ,  C07D403/06 ,  C07D405/04 ,  C07D413/06

    摘要： Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

    摘要翻译： 由式I表示的二芳基取代的吡嗪酮化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，尿失禁，瘙痒，过敏性皮炎，癫痫，肠易激综合征，抑郁症 ，焦虑，多发性硬化和双相性精神障碍，包括单独或与一种或多种其它治疗活性化合物组合施用有效量的本发明化合物。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。