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公开(公告)号：US20200216417A1
公开(公告)日：2020-07-09
申请号：US16734214
申请日：2020-01-03
申请人： Praxis Biotech LLC
发明人： Sebastian BERNALES , Brahmam PUJALA , Dayanand PANPATIL , Gonzalo Andrés URETA DÍAZ , Sebastian BELMAR
IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D417/14 , C07D413/14 , C07D471/04 , A61P35/00
摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.
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公开(公告)号：US20230047589A1
公开(公告)日：2023-02-16
申请号：US17398862
申请日：2021-08-10
申请人： Praxis Biotech LLC
发明人： Sebastian BERNALES , Luz Marina DELGADO OYARZO , Gonzalo Esteban NÚÑEZ VASQUEZ , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Bhawana BHATT , Sarvajit CHAKRAVARTY
IPC分类号： C07D413/12 , C07D263/24 , C07D307/85 , C07D401/12 , C07D405/12 , C07D215/18 , C07D211/58 , C07D491/048 , C07D277/68 , C12N5/00 , C07D265/36
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20210317102A1
公开(公告)日：2021-10-14
申请号：US16899520
申请日：2020-06-11
申请人： Praxis Biotech LLC
发明人： Luz Marina DELGADO OYARZO , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： C07D401/12 , C07D471/08 , C07D235/24 , C07D211/34 , C07D405/12 , C07C235/36 , C07D215/56 , C07D307/85 , C07D213/81 , C07D241/24 , C07D407/12 , C07D265/36 , A01N43/42 , A01N43/52 , A01N43/12 , A01N43/60 , A01N47/32 , A01N37/30 , A01N37/26 , A01N43/84 , C12P21/00
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20230083885A1
公开(公告)日：2023-03-16
申请号：US17711961
申请日：2022-04-01
申请人： Praxis Biotech LLC
发明人： Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： A61K31/4709 , C07K14/535 , C07K14/50 , C07D413/12 , C07D271/06 , C07D413/04 , C07D285/08 , C07D263/32 , C07D231/12 , C07D417/12 , C07D413/14 , C07D401/12 , A61K31/4245 , A61K31/538 , A61K31/497 , A61K31/433 , A61K31/421 , A61K31/415 , A01N43/82 , A01N43/84 , A01N43/56 , A01P21/00 , C12P21/00 , C12N5/071 , C12N15/86
摘要： The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20190177310A1
公开(公告)日：2019-06-13
申请号：US16219805
申请日：2018-12-13
申请人： Praxis Biotech LLC
发明人： Sebastian BERNALES , Luz Marina DELGADO OYARZO , Gonzalo Esteban NÚÑEZ VASQUEZ , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Bhawana BHATT , Sarvajit CHAKRAVARTY
IPC分类号： C07D413/12 , C07D265/36 , C07D263/24 , C07D307/85 , C07D401/12 , C07D405/12 , C07D215/18 , C07D211/58 , C07D491/048 , C07D277/68 , C12N5/00
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20220071966A1
公开(公告)日：2022-03-10
申请号：US17398902
申请日：2021-08-10
申请人： Praxis Biotech LLC
发明人： Luz Marina DELGADO OYARZO , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： A61K31/428 , A61P21/00 , A61P25/28 , A61K31/4468 , A61K31/4525 , A61K31/4709 , A61K31/495 , A61K31/497 , A61K31/538 , C07D221/00 , C07D241/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07K16/00 , C12N5/073
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20200270232A1
公开(公告)日：2020-08-27
申请号：US16799765
申请日：2020-02-24
申请人： Praxis Biotech LLC
发明人： Sebastian BERNALES , Luz Marina DELGADO OYARZO , Gonzalo Esteban NÙÑEZ VASQUEZ , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL
IPC分类号： C07D405/12 , A61P25/28 , A61P35/00 , A61P21/00 , C07C233/52 , C07D307/85 , C07D215/48 , C07D401/06 , C07D405/06 , C07D307/14 , C07D401/12 , C12P21/00
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20230144841A1
公开(公告)日：2023-05-11
申请号：US17944963
申请日：2022-09-14
申请人： Praxis Biotech LLC
发明人： Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sebastian BELMAR , Gonzalo Andrés URETA DÍAZ
IPC分类号： A61K31/4709 , A61K31/192 , C07D405/14 , C07D401/12 , C07D401/14 , A61P35/00
CPC分类号： A61K31/4709 , A61K31/192 , C07D405/14 , C07D401/12 , C07D401/14 , A61P35/00
摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.
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公开(公告)号：US20230042881A1
公开(公告)日：2023-02-09
申请号：US17831771
申请日：2022-06-03
申请人： Praxis Biotech LLC
发明人： Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： A61K31/47 , C07K1/10 , C07D215/38 , A61K31/4709 , C07D405/12 , A61K31/538 , C07D413/12 , C07D401/12 , C07D405/14 , C07D263/58 , A61K31/423 , A61K31/428 , C07D277/82 , C07D401/14 , A61K31/497 , A61K31/343 , C07D307/81 , C07D407/12 , C07D413/14 , A61K31/443 , A61K31/454 , C07D417/12 , A01N43/42 , A01N43/84 , A01N43/76 , A01N43/78 , A01N43/60 , A01N43/12 , A01N43/40 , A01P21/00 , A61P1/18 , C12N5/00
摘要： The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20190185451A1
公开(公告)日：2019-06-20
申请号：US16221398
申请日：2018-12-14
申请人： Praxis Biotech LLC
发明人： Jennifer ALFARO , Sebastian BELMAR , Sebastian BERNALES , Brahmam PUJALA , Dayanand PANPATIL , Bhawana BHATT
IPC分类号： C07D401/12 , C07D403/12 , C07D401/14 , C07D405/14 , C07D405/12 , C07D413/14 , C07D207/34 , C07D471/04 , C07D491/048 , A61P35/00 , A61P3/04 , A61P3/10
CPC分类号： C07D401/12 , A61P3/04 , A61P3/10 , A61P35/00 , C07D207/34 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D491/048
摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.
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