公开(公告)号：US20230078810A1

公开(公告)日：2023-03-16

申请号：US17964771

申请日：2022-10-12

Applicant: President and Fellows of Harvard College

Inventor： David A. Weitz ,  Christian Boehm ,  Amy Rowat ,  Sarah Koester ,  Jeremy Agresti

IPC: B01L3/00 ,  B01L7/00 ,  G01N33/50 ,  G01N21/64

Abstract: The present invention relates to systems and methods for the arrangement of droplets in pre-determined locations. Many applications require the collection of time-resolved data. Examples include the screening of cells based on their growth characteristics or the observation of enzymatic reactions. The present invention provides a tool and related techniques which addresses this need, and which can be used in many other situations. The invention provides, in one aspect, a tool that allows for stable storage and indexing of individual droplets. The invention can interface not only with microfluidic/microscale equipment, but with macroscopic equipment to allow for the easy injection of liquids and extraction of sample droplets, etc.

公开(公告)号：US11498072B2

公开(公告)日：2022-11-15

申请号：US17060354

申请日：2020-10-01

Applicant: President and Fellows of Harvard College

Inventor： David A. Weitz ,  Christian Boehm ,  Amy Rowat ,  Sarah Koester ,  Jeremy Agresti

IPC: B01L3/00 ,  B01L7/00 ,  G01N33/50 ,  G01N21/64

Abstract: The present invention relates to systems and methods for the arrangement of droplets in pre-determined locations. Many applications require the collection of time-resolved data. Examples include the screening of cells based on their growth characteristics or the observation of enzymatic reactions. The present invention provides a tool and related techniques which addresses this need, and which can be used in many other situations. The invention provides, in one aspect, a tool that allows for stable storage and indexing of individual droplets. The invention can interface not only with microfluidic/microscale equipment, but with macroscopic equipment to allow for the easy injection of liquids and extraction of sample droplets, etc.

公开(公告)号：US10828641B2

公开(公告)日：2020-11-10

申请号：US15496750

申请日：2017-04-25

Applicant: President and Fellows of Harvard College

Inventor： Christian Boehm ,  Amy Rowat ,  Sarah Koester ,  Jeremy Agresti ,  David A. Weitz

IPC: B01L3/00 ,  B01L7/00 ,  G01N33/50 ,  G01N21/64

Abstract: The present invention relates to systems and methods for the arrangement of droplets in pre-determined locations. Many applications require the collection of time-resolved data. Examples include the screening of cells based on their growth characteristics or the observation of enzymatic reactions. The present invention provides a tool and related techniques which addresses this need, and which can be used in many other situations. The invention provides, in one aspect, a tool that allows for stable storage and indexing of individual droplets. The invention can interface not only with microfluidic/microscale equipment, but with macroscopic equipment to allow for the easy injection of liquids and extraction of sample droplets, etc.

公开(公告)号：US20170225167A1

公开(公告)日：2017-08-10

申请号：US15496750

申请日：2017-04-25

Applicant: President and Fellows of Harvard College

Inventor： Christian Boehm ,  Amy Rowat ,  Sarah Koester ,  Jeremy Agresti ,  David A. Weitz

IPC: B01L3/00 ,  G01N21/64 ,  B01L7/00

CPC classification number: B01L3/502784 ,  B01L7/525 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/1827 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N21/6452 ,  G01N33/5008

Abstract: The present invention relates to systems and methods for the arrangement of droplets in pre-determined locations. Many applications require the collection of time-resolved data. Examples include the screening of cells based on their growth characteristics or the observation of enzymatic reactions. The present invention provides a tool and related techniques which addresses this need, and which can be used in many other situations. The invention provides, in one aspect, a tool that allows for stable storage and indexing of individual droplets. The invention can interface not only with microfluidic/microscale equipment, but with macroscopic equipment to allow for the easy injection of liquids and extraction of sample droplets, etc.

公开(公告)号：US20210086183A1

公开(公告)日：2021-03-25

申请号：US17060354

申请日：2020-10-01

Applicant: President and Fellows of Harvard College

Inventor： David A. Weitz ,  Christian Boehm ,  Amy Rowat ,  Sarah Koester ,  Jeremy Agresti

IPC: B01L3/00 ,  B01L7/00 ,  G01N33/50 ,  G01N21/64

Abstract: The present invention relates to systems and methods for the arrangement of droplets in pre-determined locations. Many applications require the collection of time-resolved data. Examples include the screening of cells based on their growth characteristics or the observation of enzymatic reactions. The present invention provides a tool and related techniques which addresses this need, and which can be used in many other situations. The invention provides, in one aspect, a tool that allows for stable storage and indexing of individual droplets. The invention can interface not only with microfluidic/microscale equipment, but with macroscopic equipment to allow for the easy injection of liquids and extraction of sample droplets, etc.