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    SCALE-UP OF MICROFLUIDIC DEVICES
    1.
    发明申请
    SCALE-UP OF MICROFLUIDIC DEVICES 有权

    公开(公告)号：US20250033009A1

    公开(公告)日：2025-01-30

    申请号：US18442367

    申请日：2024-02-15

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Mark Romanowsky ,  Adam R. Abate

    IPC: B01F33/3011 ,  B01F23/41 ,  B01F101/23 ,  B01J19/00 ,  B01L3/00

    Abstract: Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

    MICROFLUIDIC DEVICE FOR STORAGE AND WELL-DEFINED ARRANGEMENT OF DROPLETS
    6.
    发明申请
    MICROFLUIDIC DEVICE FOR STORAGE AND WELL-DEFINED ARRANGEMENT OF DROPLETS 有权

    公开(公告)号：US20230078810A1

    公开(公告)日：2023-03-16

    申请号：US17964771

    申请日：2022-10-12

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Christian Boehm ,  Amy Rowat ,  Sarah Koester ,  Jeremy Agresti

    IPC: B01L3/00 ,  B01L7/00 ,  G01N33/50 ,  G01N21/64

    Abstract: The present invention relates to systems and methods for the arrangement of droplets in pre-determined locations. Many applications require the collection of time-resolved data. Examples include the screening of cells based on their growth characteristics or the observation of enzymatic reactions. The present invention provides a tool and related techniques which addresses this need, and which can be used in many other situations. The invention provides, in one aspect, a tool that allows for stable storage and indexing of individual droplets. The invention can interface not only with microfluidic/microscale equipment, but with macroscopic equipment to allow for the easy injection of liquids and extraction of sample droplets, etc.

    Fluid injection
    8.
    发明授权
    Fluid injection 有权

    公开(公告)号：US11358105B2

    公开(公告)日：2022-06-14

    申请号：US17145684

    申请日：2021-01-11

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F25/314 ,  F16K99/00 ,  B01J19/00 ,  B01L3/00 ,  B01F33/302 ,  B01F33/3031 ,  G01N27/447 ,  G01N35/10

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    Coalescence of droplets
    9.
    发明授权
    Coalescence of droplets 有权

    公开(公告)号：US11141730B2

    公开(公告)日：2021-10-12

    申请号：US14896218

    申请日：2014-06-12

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Thomas E. Kodger ,  Donald Aubrecht ,  Ilke Akartuna

    IPC: B01L3/00 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00

    Abstract: The present invention generally relates to microfluidics, and, in particular, to systems and methods for coalescing or fusing droplets. In certain aspects, two or more droplets within a microfluidic channel are brought together and caused to coalesce without using electric fields or charges. For example, in certain embodiments, droplets stabilized with a surfactant may be disrupted, e.g., by exposing the droplets to a solvent able to alter the surfactant, which may partially destabilize the droplets and allow them to coalesce. In some instances, the droplets may also be physically disrupted to facilitate coalesce. In addition, in some cases, the positions of one or more droplets may be controlled within a channel using a groove in a wall of the channel. For example, a droplet may at least partially enter the groove such that the position of the droplet is at least partially controlled by the groove.

    DROPLET CREATION TECHNIQUES
    10.
    发明申请
    DROPLET CREATION TECHNIQUES 有权

    公开(公告)号：US20210229099A1

    公开(公告)日：2021-07-29

    申请号：US17148287

    申请日：2021-01-13

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate

    IPC: B01L3/00 ,  B01F13/00 ,  B01F3/08

    Abstract: The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes.

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