公开(公告)号：US20160114046A1

公开(公告)日：2016-04-28

申请号：US14878578

申请日：2015-10-08

申请人： President and Fellows of Harvard College

发明人： Yevgeny Brudno ,  Cathal J. Kearney ,  Eduardo Silva ,  Michael Aizenberg ,  Brian Kwee ,  Rajiv Desai ,  Neel S. Joshi ,  David J. Mooney

IPC分类号： A61K47/36 ,  A61K9/00 ,  A61K31/704

CPC分类号： A61K47/4823 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6903 ,  A61K49/0021 ,  A61K49/0054 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2320/32

摘要： The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.

公开(公告)号：US20170232074A1

公开(公告)日：2017-08-17

申请号：US15436358

申请日：2017-02-17

申请人： President and Fellows of Harvard College ,  Brown University

发明人： David J. Mooney ,  Cristina Borselli ,  Herman Vandenburgh ,  Eduardo Silva ,  Lin Wang, I ,  Dmitry Shvartsman ,  Hannah Storrie ,  Jeff Lichtman

IPC分类号： A61K38/30 ,  A61K9/19 ,  A61K38/18 ,  A61L27/38 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61K9/06 ,  A61K35/34

CPC分类号： A61K38/30 ,  A61K9/06 ,  A61K9/19 ,  A61K35/12 ,  A61K35/34 ,  A61K38/18 ,  A61K38/1866 ,  A61L27/20 ,  A61L27/3612 ,  A61L27/3826 ,  A61L27/3873 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2400/16 ,  A61L2430/32 ,  C08L2201/12 ,  A61K2300/00

摘要： An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.

公开(公告)号：US20170119892A1

公开(公告)日：2017-05-04

申请号：US15300880

申请日：2015-04-06

申请人： President and Fellows of Harvard College

发明人： Yevgeny Brudno ,  Cathal J. Kearney ,  Eduardo Silva ,  Michael Aizenberg ,  Brian Kwee ,  Rajiv Desai ,  Neel S. Joshi ,  David J. Mooney

IPC分类号： A61B10/00 ,  A61K9/06 ,  A61K49/00 ,  C12N15/113 ,  A61K31/704

CPC分类号： A61K47/4823 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6903 ,  A61K49/0021 ,  A61K49/0054 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2320/32

摘要： The present invention provides refillable drug delivery devices. The invention is based in part on the development of systemically administered drug payloads that home to and refill resident, e.g., previously administered/implanted, drug delivery systems, e.g., hydrogel drug delivery systems. In one aspect, the drug delivery depots of the invention are systemically administered, e.g., enterally administered or parenterally administered. The invention provides a method of nanotherapeutic drug delivery, e.g., a DNA nanotechnology-based approach for blood-based drug refilling of intra-tumor drug depots.

公开(公告)号：US20160220686A1

公开(公告)日：2016-08-04

申请号：US15097092

申请日：2016-04-12

申请人： President and Fellows of Harvard College

发明人： Yevgeny Brudno ,  Cathal J. Kearney ,  Eduardo Silva ,  Michael Aizenberg ,  Brian Kwee ,  Rajiv Desai ,  Neel S. Joshi ,  David J. Mooney

IPC分类号： A61K47/48 ,  A61K31/704 ,  A61K9/00

CPC分类号： A61K47/4823 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6903 ,  A61K49/0021 ,  A61K49/0054 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2320/32

摘要： The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.

摘要翻译： 本发明提供可重复填充的药物递送系统，以及重新填充系统的方法，以及使用它们治疗疾病的方法。