公开(公告)号：US09683197B2

公开(公告)日：2017-06-20

申请号：US14268171

申请日：2014-05-02

申请人： President and Fellows of Harvard College

发明人： Joanna Aizenberg ,  Benjamin Hatton ,  Xi Yao ,  Michael Aizenberg ,  Wendong Wang

IPC分类号： C10M171/00 ,  A61L27/50 ,  A61L29/14 ,  A61L15/50 ,  A61L27/56 ,  A61L15/42 ,  A61F2/28 ,  B05D3/00 ,  B05D3/02 ,  B05D3/06 ,  B05D3/12 ,  B05D3/14 ,  F17D1/08 ,  A61M31/00

CPC分类号： C10M171/001 ,  A61F2/28 ,  A61F2240/001 ,  A61L15/425 ,  A61L15/50 ,  A61L27/50 ,  A61L27/56 ,  A61L29/14 ,  A61L29/146 ,  A61L2400/10 ,  A61L2400/16 ,  A61L2400/18 ,  A61M31/00 ,  B05D3/007 ,  B05D3/0254 ,  B05D3/06 ,  B05D3/12 ,  B05D3/14 ,  B05D3/207 ,  F17D1/08 ,  Y10T137/0324 ,  Y10T428/139 ,  Y10T428/24355

摘要： The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS) that can be modified as desired. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of objects, referred to herein as Object A (Solid A or Liquid A). Use of an external stimuli or degradation of the Liquid B can be utilized to change the characteristics of SLIPS structures reversibly or irreversibly that may be desired in a number of different applications. Numerous characteristics, such as adhesion, optical, mechanical, and the like, can be dynamically changed.

公开(公告)号：US20220401562A1

公开(公告)日：2022-12-22

申请号：US17569720

申请日：2022-01-06

申请人： President and Fellows of Harvard College

发明人： Yevgeny Brudno ,  Cathal J. Kearney ,  Eduardo Alexandre Barros E Silva ,  Michael Aizenberg ,  Brian Kwee ,  Rajiv Desai ,  Neel Satish Joshi ,  David J. Mooney

IPC分类号： A61K47/54 ,  A61K9/00 ,  A61K9/06 ,  A61K47/69 ,  A61K47/36 ,  A61K31/704 ,  A61K49/00 ,  C12N15/113

摘要： The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.

公开(公告)号：US11118067B2

公开(公告)日：2021-09-14

申请号：US15879526

申请日：2018-01-25

申请人： President and Fellows of Harvard College

发明人： Joanna Aizenberg ,  Michael Aizenberg ,  Sung Hoon Kang ,  Philseok Kim ,  Tak Sing Wong

IPC分类号： B05D3/00 ,  C09D5/00 ,  C09D5/16 ,  A61L27/28 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  B01L3/00 ,  B65D25/14 ,  H01L31/0236 ,  G02B1/14 ,  C10M105/54 ,  C10M105/56 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F28F13/18 ,  F28F19/02 ,  B05D5/00 ,  B01D69/02 ,  B05D5/08 ,  B63B59/04 ,  B64D15/00 ,  C02F1/44 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F16L57/00 ,  H01L31/0216

摘要： The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). Slippery liquid-infused porous surfaces outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US09121307B2

公开(公告)日：2015-09-01

申请号：US14140391

申请日：2013-12-24

申请人： President and Fellows of Harvard College

发明人： Joanna Aizenberg ,  Michael Aizenberg ,  Sung Hoon Kang ,  Tak Sing Wong ,  Philseok Kim

IPC分类号： H01L31/0236 ,  F01D25/18 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  C09D5/16 ,  F15D1/02 ,  F15D1/10 ,  B05D5/00 ,  B05D3/00 ,  F28F13/18 ,  B05D5/08

CPC分类号： C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B01D69/02 ,  B01D2325/06 ,  B01L3/5027 ,  B01L2300/16 ,  B05D3/002 ,  B05D5/00 ,  B05D5/083 ,  B63B59/04 ,  B64D15/00 ,  B65D25/14 ,  C02F1/44 ,  C09D5/16 ,  C09D5/1656 ,  C09D5/1681 ,  C09D5/1693 ,  C10M105/54 ,  C10M105/56 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F16L57/00 ,  F28F13/185 ,  F28F19/02 ,  F28F2245/04 ,  G02B1/14 ,  H01L31/02167 ,  H01L31/0236 ,  Y10T428/24355 ,  Y10T428/24364 ,  C08L27/12

摘要： The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

摘要翻译： 本公开描述了创建自愈合，滑动的液体注入的多孔表面（SLIPS）的策略。 可以使用粗化的（例如，多孔的）表面将本文称为液体B的润滑流体锁定在一起，以排斥本文称为对象A（固体A或液体A）的宽范围的材料。 SLIPS优于其他常规表面，以排斥各种简单而复杂的液体（水，碳氢化合物，原油和血液），保持低接触角滞后（<2.5°），在物理损伤后迅速恢复拒水性（0.1以内） -1 s），抗冰，微生物和昆虫粘附，并在高压（至多690 atm）下起作用。 SLIPS将有用的一些示例性应用包括在极端环境中运行的节能流体处理和运输，光学传感，医药以及自清洁以及防污材料。

公开(公告)号：US09121306B2

公开(公告)日：2015-09-01

申请号：US14140374

申请日：2013-12-24

申请人： President and Fellows of Harvard College

发明人： Joanna Aizenberg ,  Michael Aizenberg ,  Sung Hoon Kang ,  Tak Sing Wong ,  Philseok Kim

IPC分类号： F01D25/18 ,  B05D3/00 ,  F28F13/18 ,  H01L31/0236 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  C09D5/16 ,  F15D1/02 ,  F15D1/10 ,  B05D5/00 ,  B05D5/08

CPC分类号： C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B01D69/02 ,  B01D2325/06 ,  B01L3/5027 ,  B01L2300/16 ,  B05D3/002 ,  B05D5/00 ,  B05D5/083 ,  B63B59/04 ,  B64D15/00 ,  B65D25/14 ,  C02F1/44 ,  C09D5/16 ,  C09D5/1656 ,  C09D5/1681 ,  C09D5/1693 ,  C10M105/54 ,  C10M105/56 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F16L57/00 ,  F28F13/185 ,  F28F19/02 ,  F28F2245/04 ,  G02B1/14 ,  H01L31/02167 ,  H01L31/0236 ,  Y10T428/24355 ,  Y10T428/24364 ,  C08L27/12

摘要： The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US09963597B2

公开(公告)日：2018-05-08

申请号：US14414291

申请日：2013-07-12

申请人： President and Fellows of Harvard College

发明人： Joanna Aizenberg ,  Michael Aizenberg ,  Jiaxi Cui ,  Stuart Dunn ,  Benjamin Hatton ,  Caitlin Howell ,  Philseok Kim ,  Tak Sing Wong ,  Xi Yao

IPC分类号： C09D5/16 ,  A61L29/08 ,  A61L29/14 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  C10M171/00 ,  C09D201/00 ,  B01D65/08 ,  B08B17/02 ,  B08B17/06 ,  C10M105/76 ,  B05D5/08

CPC分类号： C09D5/1637 ,  A61L29/085 ,  A61L29/14 ,  A61L31/04 ,  A61L31/049 ,  A61L31/06 ,  A61L31/14 ,  A61L2400/10 ,  B01D65/08 ,  B01D2321/00 ,  B05D5/08 ,  B08B17/025 ,  B08B17/065 ,  C08J2300/00 ,  C09D5/1675 ,  C09D5/1693 ,  C09D201/005 ,  C10M105/76 ,  C10M171/00 ,  C10M2203/1006 ,  C10M2229/025 ,  C10M2229/0515 ,  C10N2250/18 ,  C10N2270/00 ,  C08L83/04

摘要： The present disclosure describes a strategy to create self-healing, slippery self-lubricating polymers. Lubricating liquids with affinities to polymers can be utilized to get absorbed within the polymer and form a lubricant layer (of the lubricating liquid) on the polymer. The lubricant layer can repel a wide range of materials, including simple and complex fluids (water, hydrocarbons, crude oil and bodily fluids), restore liquid-repellency after physical damage, and resist ice, microorganisms and insects adhesion. Some exemplary applications where self-lubricating polymers will be useful include energy-efficient, friction-reduction fluid handling and transportation, medical devices, anti-icing, optical sensing, and as self-cleaning, and anti-fouling materials operating in extreme environments.

公开(公告)号：US09932482B2

公开(公告)日：2018-04-03

申请号：US15134070

申请日：2016-04-20

申请人： President and Fellows of Harvard College

发明人： Joanna Aizenberg ,  Michael Aizenberg ,  Sung Hoon Kang ,  Philseok Kim ,  Tak Sing Wong

IPC分类号： C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  C09D5/16 ,  F15D1/02 ,  F15D1/10 ,  B05D5/00 ,  B05D3/00 ,  F01D25/18 ,  F28F13/18 ,  H01L31/0236 ,  G02B1/14 ,  B01L3/00 ,  B65D25/14 ,  C10M105/54 ,  C10M105/56 ,  F28F19/02 ,  B05D5/08 ,  B01D69/02 ,  B63B59/04 ,  B64D15/00 ,  C02F1/44 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F16L57/00 ,  H01L31/0216

CPC分类号： C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B01D69/02 ,  B01D2325/06 ,  B01L3/5027 ,  B01L2300/16 ,  B05D3/002 ,  B05D5/00 ,  B05D5/083 ,  B63B59/04 ,  B64D15/00 ,  B65D25/14 ,  C02F1/44 ,  C09D5/16 ,  C09D5/1656 ,  C09D5/1681 ,  C09D5/1693 ,  C10M105/54 ,  C10M105/56 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F16L57/00 ,  F28F13/185 ,  F28F19/02 ,  F28F2245/04 ,  G02B1/14 ,  H01L31/02167 ,  H01L31/0236 ,  Y10T428/24355 ,  Y10T428/24364 ,  C08L27/12

摘要： The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US20170119892A1

公开(公告)日：2017-05-04

申请号：US15300880

申请日：2015-04-06

申请人： President and Fellows of Harvard College

发明人： Yevgeny Brudno ,  Cathal J. Kearney ,  Eduardo Silva ,  Michael Aizenberg ,  Brian Kwee ,  Rajiv Desai ,  Neel S. Joshi ,  David J. Mooney

IPC分类号： A61B10/00 ,  A61K9/06 ,  A61K49/00 ,  C12N15/113 ,  A61K31/704

CPC分类号： A61K47/4823 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6903 ,  A61K49/0021 ,  A61K49/0054 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2320/32

摘要： The present invention provides refillable drug delivery devices. The invention is based in part on the development of systemically administered drug payloads that home to and refill resident, e.g., previously administered/implanted, drug delivery systems, e.g., hydrogel drug delivery systems. In one aspect, the drug delivery depots of the invention are systemically administered, e.g., enterally administered or parenterally administered. The invention provides a method of nanotherapeutic drug delivery, e.g., a DNA nanotechnology-based approach for blood-based drug refilling of intra-tumor drug depots.

公开(公告)号：US20160220686A1

公开(公告)日：2016-08-04

申请号：US15097092

申请日：2016-04-12

申请人： President and Fellows of Harvard College

发明人： Yevgeny Brudno ,  Cathal J. Kearney ,  Eduardo Silva ,  Michael Aizenberg ,  Brian Kwee ,  Rajiv Desai ,  Neel S. Joshi ,  David J. Mooney

IPC分类号： A61K47/48 ,  A61K31/704 ,  A61K9/00

CPC分类号： A61K47/4823 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6903 ,  A61K49/0021 ,  A61K49/0054 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2320/32

摘要： The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.

摘要翻译： 本发明提供可重复填充的药物递送系统，以及重新填充系统的方法，以及使用它们治疗疾病的方法。

公开(公告)号：US20140342954A1

公开(公告)日：2014-11-20

申请号：US14371728

申请日：2013-01-10

申请人： President and Fellows of Harvard College

发明人： Donald Ingber ,  Daniel C. Leslie ,  Alexander L. Watters ,  Michael Super ,  Joanna Aizenberg ,  Michael Aizenberg ,  Philseok Kim ,  Anna Waterhouse

IPC分类号： A61L33/04

CPC分类号： A61L33/04 ,  A61L29/06 ,  A61L29/08 ,  A61L29/14 ,  A61L33/0041 ,  A61L33/0094 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  B05D1/60 ,  B05D3/107 ,  B05D5/086 ,  B05D7/02 ,  C09D5/1656 ,  C09D5/1693 ,  C08L83/04

摘要： Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has a head group that is covalently linked to, or adsorbed onto, the surface and a functional group. The functional group of the treated surface has an affinity for a lubricating layer, which is applied to the treated surface. The anchoring layer and replenishable lubricating layer are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.

摘要翻译： 公开了制品的制造方法和用于改性表面的疏液性的用途。 排液表面包括包含锚定层的表面。 在表面上形成固定化分子锚定层的锚定层具有共价连接或吸附在表面上的头基和官能团。 经处理的表面的官能团对施加到被处理表面的润滑层具有亲和性。 锚定层和可补充润滑层通过非共价吸引力保持在一起。 这些层一起形成一个超疏水滑表面，排斥某些不混溶液体，并防止其中所含组分的吸附，凝结和表面结垢。