公开(公告)号：US20180071690A1

公开(公告)日：2018-03-15

申请号：US15558191

申请日：2016-03-16

Applicant: President and Fellows of Harvard College

Inventor： James Coon ,  Tiama Hamkins-Indik ,  Donald E. Ingber ,  Miles Ingram ,  Daniel Levner ,  Richard Novak ,  Jefferson Puerta ,  Daniel E. Shea ,  Josiah Sliz ,  Norman Wen

IPC: B01D67/00 ,  B01D71/70 ,  B29C41/38 ,  B29C33/42 ,  B29C33/68 ,  B29C39/00 ,  B29C39/26 ,  B29C41/12 ,  C12M1/12

CPC classification number: B01D67/0034 ,  B01D71/70 ,  B01L3/502707 ,  B01L2300/123 ,  B01L2400/086 ,  B29C33/424 ,  B29C33/68 ,  B29C39/006 ,  B29C39/26 ,  B29C41/12 ,  B29C41/36 ,  B29C41/38 ,  B29C2043/025 ,  B29L2031/755 ,  B29L2031/756 ,  C12M25/02

Abstract: A method for micro-molding a polymeric membrane and including pouring a predetermined volume of curable polymer unto a micro-fabricated mold having a post array with pillars, and overlaying the polymer with a support substrate. A spacer, such as a rubber spacer, is placed in contact with the support substrate and a force is applied to an exposed side of the spacer to compress the support substrate and the polymer together. While applying the force, the polymer is cured on the mold for a predetermined time period and at a predetermined temperature to form a polymeric membrane having a pore array with a plurality of pores corresponding to the plurality of pillars of the post array. The polymeric membrane is removed from the support substrate.