公开(公告)号：US20050159700A1

公开(公告)日：2005-07-21

申请号：US11039520

申请日：2005-01-19

申请人： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

发明人： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

IPC分类号： A61N1/30 ,  A61B17/20

CPC分类号： A61N1/0448 ,  A61N1/0436 ,  A61N1/044

摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

公开(公告)号：US20050159699A1

公开(公告)日：2005-07-21

申请号：US11039519

申请日：2005-01-19

申请人： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

发明人： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

IPC分类号： A61N1/30 ,  A61B17/20

CPC分类号： A61N1/0448 ,  A61N1/0436 ,  A61N1/044

摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

公开(公告)号：US20050159698A1

公开(公告)日：2005-07-21

申请号：US11039514

申请日：2005-01-19

申请人： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

发明人： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

IPC分类号： A61N1/30 ,  A61B17/20

CPC分类号： A61N1/0448 ,  A61N1/0436 ,  A61N1/044

摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic crosslinked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

摘要翻译： 用于离子电渗药物递送装置的本发明的储存器电极组件包括位于与电极导电关系的电极和亲水性储存器。 亲水性储存器由具有粘附到电极的第一表面和第二表面的吸水性亲水性交联聚合物材料形成。 当应用于患者皮肤区域时，聚合物材料的第一表面可剥离地粘附。 聚合物材料具有内聚强度，其形成粘合剂粘合，聚合物材料的第二表面与电极之间的粘合强度大于聚合物材料的内聚强度。 此外，聚合物材料的第一表面与患者的施用区域的粘合粘合强度小于聚合材料的内聚强度，使得当从患者的施用区域移除本发明的储器组件时， 基本上没有聚合物材料保留在施加的区域上，并且亲水性储存器保持基本上完整且粘附到电极上。

公开(公告)号：US20050131338A1

公开(公告)日：2005-06-16

申请号：US11039518

申请日：2005-01-19

申请人： Preston Keusch ,  NRK Vilambi ,  Bruce Eliash

发明人： Preston Keusch ,  NRK Vilambi ,  Bruce Eliash

IPC分类号： A61N1/30 ,  A61B17/20

CPC分类号： A61N1/0448 ,  A61N1/0436 ,  A61N1/044

摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

公开(公告)号：US06394994B1

公开(公告)日：2002-05-28

申请号：US09384765

申请日：1999-08-27

申请人： Nrk Vilambi ,  Bruce M. Eliash ,  Preston Keusch ,  Lue Huai Li ,  Elena N. Chabala ,  Uday K. Jain ,  Louis J. Mestichelli

发明人： Nrk Vilambi ,  Bruce M. Eliash ,  Preston Keusch ,  Lue Huai Li ,  Elena N. Chabala ,  Uday K. Jain ,  Louis J. Mestichelli

IPC分类号： A61M3100

CPC分类号： A61N1/0428

摘要： A method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament includes providing an iontophoretic reservoir-electrode with a contact surface having a shape, a suitable electrical connection and a hydrated bibulous reservoir containing an ionized medicament. The method further includes providing another electrode operating a at preselected polarity opposite to the preselected polarity of the medicament reservoir-electrode. The method further includes providing a separation medium having the property of allowing passage therein to of ions of one charge. The separation medium is positioned between the reservoir electrode with the ionized medicament and the another electrode. The method also includes applying a sufficient electrical potential between the iontophoretic reservoir-electrode containing the ionized medicament and the another iontophoretic reservoir-electrode so that a current flows through the separation medium for a preselected time thereby transporting a quantity of the ionized medicament into the separation medium. The method then includes determining an amount of the ionizable medicament in the separation medium.

摘要翻译： 用于测试离子电渗储存器电极递送药物的能力的方法包括提供具有形状，合适的电连接的接触表面和含有电离药物的水合吸水性储存器的离子电渗储器电极。 该方法还包括提供另外的电极，其操作的预选极性与药物储存器电极的预选极性相反。 该方法还包括提供一种分离介质，该分离介质具有允许通过一次电荷的离子的性质。 分离介质位于储存器电极与电离药物和另一电极之间。 该方法还包括在包含电离药物的离子电渗储存器电极和另一离子电渗储存器电极之间施加足够的电势，使得电流流过分离介质预选的时间，从而将一定量的离子化药物输送到分离 中。 该方法然后包括确定分离介质中的可离子化药物的量。

公开(公告)号：US06377847B1

公开(公告)日：2002-04-23

申请号：US09328329

申请日：1999-06-09

申请人： Preston Keusch ,  NRK Vilambi ,  Bruce Michael Eliash

发明人： Preston Keusch ,  NRK Vilambi ,  Bruce Michael Eliash

IPC分类号： A61N130

CPC分类号： A61N1/0448 ,  A61F2013/0296 ,  A61N1/0436 ,  A61N1/044

摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

摘要翻译： 用于离子电渗药物递送装置的本发明的储存器电极组件包括位于与电极导电关系的电极和亲水性储存器。 亲水性储存器由具有第一表面和吸附在电极上的第二表面的吸水性亲水性交联聚合物材料形成。 当应用于患者皮肤区域时，聚合物材料的第一表面可剥离地粘附。 聚合物材料具有内聚强度，其形成粘合剂粘合，聚合物材料的第二表面与电极之间的粘合强度大于聚合物材料的内聚强度。 此外，聚合物材料的第一表面与患者的施用区域的粘合粘合强度小于聚合材料的内聚强度，使得当从患者的施用区域移除本发明的储器组件时， 基本上没有聚合物材料保留在施加的区域上，并且亲水性储存器保持基本上完整且粘附到电极上。

公开(公告)号：US07043297B2

公开(公告)日：2006-05-09

申请号：US11039518

申请日：2005-01-19

申请人： Preston Keusch ,  NRK Vilambi ,  Bruce Michael Eliash

发明人： Preston Keusch ,  NRK Vilambi ,  Bruce Michael Eliash

IPC分类号： A61N1/30

CPC分类号： A61N1/0448 ,  A61N1/0436 ,  A61N1/044

摘要： A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

公开(公告)号：US20090312688A1

公开(公告)日：2009-12-17

申请号：US12355521

申请日：2009-01-16

申请人： Vilambi NRK Reddy ,  Preston Keusch

发明人： Vilambi NRK Reddy ,  Preston Keusch

IPC分类号： A61N1/30 ,  A61M19/00

CPC分类号： A61N1/0448 ,  A61K9/0009 ,  A61N1/044 ,  A61N1/325 ,  A61N1/36021

摘要： A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.

摘要翻译： 提供了一种用于产生临床可接受的皮肤麻醉和感觉的麻醉剂和血管收缩剂的高效电运输的稳定的电辅助透皮药物递送系统。 在某些实施方案中，麻醉剂包括利多卡因，血管收缩剂包括肾上腺素。 如通过各种指标测试所测量，药物输送受影响以在输送期间提供很少或没有感觉的皮肤麻醉。 还提供了在患者体内产生真皮麻醉的方法。

公开(公告)号：US20050228335A1

公开(公告)日：2005-10-13

申请号：US10820346

申请日：2004-04-07

申请人： Vilambi Reddy ,  Preston Keusch ,  Robert Strowe ,  Jeffrey Kapec ,  Kazuna Tanaka

发明人： Vilambi Reddy ,  Preston Keusch ,  Robert Strowe ,  Jeffrey Kapec ,  Kazuna Tanaka

IPC分类号： A61N1/30

CPC分类号： A61N1/0448 ,  A61N1/044

摘要： Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition to a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements.

摘要翻译： 提供了集成电极装置，组件和系统的各种实施例，其被构造为与被配置为将组合物递送到膜的电辅助输送装置相关联地使用。 集成电极装置，组件和系统包括各种结构，物理，机械，电和机电增强中的一种或多种。

公开(公告)号：US06387325B1

公开(公告)日：2002-05-14

申请号：US09414803

申请日：1999-10-08

申请人： Preston Keusch ,  Stephen C. Wardlaw

发明人： Preston Keusch ,  Stephen C. Wardlaw

IPC分类号： G01N3300

CPC分类号： G01N1/4077 ,  G01N1/38 ,  G01N15/1456 ,  G01N2001/302 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1486 ,  G02B21/34

摘要： Formed constituents in an aqueous based fluid biologic material sample are separated from the aqueous constituent of the sample, and are concentrated in an examining instrument's focal plane where they can be examined under magnification. Examples of fluids that can be analyzed in this fashion include urine; cerebrospinal fluid; pleural fluid; ascites; fluids aspirated from cysts such as thyroid and breast cysts; cytologic specimens which have been placed in an aqueous fluid; platelet-rich plasma; and the like. The sample is placed in a chamber having a layer of a hydrophilic hydrogel covering a surface of the chamber. An opposite surface of the chamber is transparent, and may be formed by a microscope slide cover slip, or the like. The volume of hydrogel in the chamber is sufficient so that, when the hydrogel absorbs essentially all of the aqueous fraction of the sample, the hydrogel will expand and fill the chamber. The capture surface of the expanded hydrogel is preferably planar, and any formed constituents in the sample will be captured on the capture surface of the hydrogel layer, and will not be absorbed into the hydrogel. Formed constituents, such as: cells; bacteria; crystals; protozoa; ova; parasites; and the like, can be differentially highlighted by use of labeled antibodies, selective stains, or the like, so as to enable optical examination and differentiation of various formed constituents which may be in the sample. Formed constituents may be harvested from the capture surface of the expanded hydrogel layer for more detailed examination and analysis. The capture surface of the hydrogel may be provided with a plurality of beads for use in locating the capture surface with an optical scanning instrument, and for re-establishing previously scanned fields of view.

摘要翻译： 将含水基流体生物材料样品中的成分与样品的水性成分分离，并浓缩在检查仪的焦平面上，在此可以在放大倍数下进行检查。 可以以这种方式分析的流体的实例包括尿液; 脑脊液 胸膜液 腹水; 从囊肿如甲状腺和乳腺囊肿吸出的液体; 已经置于水性液体中的细胞学标本; 血小板富集血浆 等等。 将样品放置在具有覆盖室的表面的亲水性水凝胶层的室中。 室的相对表面是透明的，并且可以由显微镜滑盖盖等形成。 腔室中的水凝胶的体积是足够的，使得当水凝胶基本上吸收样品的所有含水部分时，水凝胶将膨胀并填充室。 膨胀的水凝胶的捕获表面优选是平面的，并且样品中的任何形成的成分将被捕获在水凝胶层的捕获表面上，并且不会被吸收到水凝胶中。 形成成分，如：细胞; 菌; 晶体 原生动物 奥娃 寄生虫 可以通过使用标记的抗体，选择性污渍等差异地突出显示，以便能够对可能在样品中的各种形成的成分进行光学检查和分化。 可以从膨胀的水凝胶层的捕获表面收获成形成分，以进行更详细的检查和分析。 水凝胶的捕获表面可以设置有多个珠子，用于使用光学扫描仪器来定位捕获表面，并且用于重建先前扫描的视场。