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公开(公告)号：US20230278968A1
公开(公告)日：2023-09-07
申请号：US18169326
申请日：2023-02-15
申请人： Promega Corporation
发明人： Ce Shi , Jian Cao , Wenhui Zhou
IPC分类号： C07D265/38 , C12Q1/686 , C12Q1/6876
CPC分类号： C07D265/38 , C12Q1/686 , C12Q1/6876
摘要： Disclosed herein are functionalized oxazine dye compounds, compositions comprising the compounds, and methods of using the compounds, e.g., in nucleic acid amplification reactions. Also disclosed herein are labeled oligonucleotides and labeled nucleotide triphosphate compounds.
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公开(公告)号：US20240191211A1
公开(公告)日：2024-06-13
申请号：US18312487
申请日：2023-05-04
申请人： Promega Corporation
发明人： Rachel Friedman Ohana , Ce Shi , Robin Hurst , Mark A. Klein , Jian Cao , Thomas Kirkland , Connor Fitzgerald , Tetsuo Uyeda , Thomas Machleidt , Wenhui Zhou , Matthew A. Larsen , Hui Wang , Weiwei An , Karilyn Porter
CPC分类号： C12N9/0069 , B01J31/2295 , B01J35/39 , C12Y113/12013
摘要： Provided herein are systems, methods, and compositions for bioluminescence-triggered catalysis of bioorthogonal labeling chemistries in a proximity dependent manner. In particular, provided herein are bioluminescent proteins or complexes, luminophore substrates thereof, photocatalysts or photosensitizers, activatable labels, and systems thereof, and methods of catalytically activating the activatable labels via bioluminescence-triggered catalysis.
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公开(公告)号：US20230142197A1
公开(公告)日：2023-05-11
申请号：US18054841
申请日：2022-11-11
申请人： Promega Corporation
IPC分类号： C12N15/10 , C12Q1/6888 , C12Q1/6806
CPC分类号： C12N15/101 , C12Q1/6888 , C12Q1/6806 , C12Q2600/156
摘要： Provided herein are methods, reagents, and kits for the isolation of sperm cells from other cell types and the purification of sperm-associated DNA from a complex sample. In particular, methods, reagents, and kits are provided for the separation of intact sperm cells from epithelial cells via binding of sperm cells to a cation exchange resin, and the extraction of sperm-associated DNA therefrom.
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公开(公告)号：US20230357266A1
公开(公告)日：2023-11-09
申请号：US18312418
申请日：2023-05-04
申请人： Promega Corporation
发明人： Matthew A. Larsen , Rachel Friedman Ohana , Wenhui Zhou , Ce Shi , Jian Cao , Robin Hurst , Mark A. Klein , Hui Wang , Weiwei An , Karilyn Porter , Thomas Machleidt
IPC分类号： C07D495/04 , B01J23/46 , B01J35/00 , C07B59/00
CPC分类号： C07D495/04 , B01J23/468 , B01J23/462 , B01J35/004 , C07B59/002 , C07B2200/05
摘要： Provided herein are compounds, compositions, systems, and methods for photoactivatable labeling, which can be actuated within biological systems. In particular, compounds disclosed herein include vinyl-extended-aryl azide moieties that undergo photoactivation to generate reactive intermediates, which can form covalent linkages with biomolecules. The photoactivation can be conducted by a variety of mechanisms including ultraviolet (UV) irradiation, visible light irradiation, or energy transfer (e.g., from a photocatalyst). The compounds also include functional moieties that provide useful functionalities, for example detection of biomolecules, such as fluorophores, capture elements (e.g., biotin), or reactive moieties (e.g., click handles) and bifunctional moieties comprising a bioactive compound and a detection/capture element.
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