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1.发明申请公开(公告)号：US20160075754A1
公开(公告)日：2016-03-17
申请号：US14849963
申请日：2015-09-10
Applicant: Protalix Ltd.
Inventor： Yoseph SHAALTIEL , Uri Hanania , Tali Kizhner , Tami Ariel , Svetlana Gingis-Velitski , Myriam Golembo
IPC: C07K14/705
CPC classification number: C07K14/7151 , A61K36/00 , A61K38/1793 , C07K2319/02 , C07K2319/30 , C12N15/8257
Abstract: A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising:(i) a first domain which comprises a TNF Alpha binding domain of a TNF receptor, and (ii) a second domain which comprises an Fc domain of an immunoglobulin, wherein the first domain and the second domain are N-terminally to C-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds TNF Alpha.
Abstract translation: 提供植物产生的嵌合多肽。 植物产生嵌合多肽，其包含：（i）包含TNF受体的TNFα结合结构域的第一结构域，和（ii）包含免疫球蛋白Fc结构域的第二结构域，其中第一结构域和第二结构域是 N末端至C末端分别顺序翻译融合并且其中所述嵌合多肽特异性结合TNFα。
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公开(公告)号：US20150010617A1
公开(公告)日：2015-01-08
申请号：US14375439
申请日：2013-01-31
Applicant: Protalix Ltd.
Inventor： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Yulia Matiuhin , Liat Fux , Avidor Shulman
CPC classification number: A61K38/465 , A61K9/007 , A61K9/0075 , A61K9/14 , A61K33/06 , A61K33/14 , A61K38/47 , A61K45/06 , C12N9/22 , C12N15/8221 , C12N15/8257 , C12Y301/21001 , C12Y302/01052
Abstract: An inhalable pharmaceutical composition for pulmonary administration comprising human DNase I and a liquid carrier and, more particularly, but not exclusively, to methods, liquid pharmaceutical inhalation devices and systems for the therapeutic use thereof are provided.
Abstract translation: 提供了一种用于肺部给药的可吸入药物组合物，其包含人类DNA酶I和液体载体，更具体地但不排他地涉及用于其治疗用途的方法，液体药物吸入装置和系统。
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公开(公告)号：US10087232B2
公开(公告)日：2018-10-02
申请号：US14773349
申请日：2014-03-06
Inventor： Yaron Ilan , Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Tami Ariel , Svetlana Gingis-Velitski
IPC: A61K39/00 , A61K38/00 , A61K38/16 , C07K14/705 , C07K14/525 , C12N15/82 , A61K9/00 , A61K36/81 , C07K16/24
Abstract: A method of treating a TNF Alpha associated medical condition selected from the group consisting of obesity, metabolic syndrome, diabetes and a liver disease or disorder is provided. The method comprising enterally administering to a subject in need thereof a therapeutically effective amount of plant cells expressing a TNF Alpha polypeptide inhibitor, thereby treating the TNF Alpha associated medical condition.
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公开(公告)号：US10000551B2
公开(公告)日：2018-06-19
申请号：US14849963
申请日：2015-09-10
Applicant: Protalix Ltd.
Inventor： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Tami Ariel , Svetlana Gingis-Velitski , Myriam Golembo
IPC: A61K39/00 , C07K14/705 , A61K38/17 , A61K36/00
CPC classification number: C07K14/7151 , A61K36/00 , A61K38/1793 , C07K2319/02 , C07K2319/30 , C12N15/8257
Abstract: A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising:(i) a first domain which comprises a TNF Alpha binding domain of a TNF receptor, and(ii) a second domain which comprises an Fc domain of an immunoglobulin, wherein the first domain and the second domain are N-terminally to C-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds TNF Alpha.
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Patent Agency Ranking
公开(公告)号：US09603906B2
公开(公告)日：2017-03-28
申请号：US14375439
申请日：2013-01-31
Applicant: Protalix Ltd.
Inventor： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Yulia Matiuhin , Liat Fux , Avidor Shulman
IPC: A61K38/46 , C12N9/22 , C12N15/82 , A61K9/00 , A61K38/47 , A61K33/06 , A61K45/06 , A61K9/14 , A61K33/14
CPC classification number: A61K38/465 , A61K9/007 , A61K9/0075 , A61K9/14 , A61K33/06 , A61K33/14 , A61K38/47 , A61K45/06 , C12N9/22 , C12N15/8221 , C12N15/8257 , C12Y301/21001 , C12Y302/01052
Abstract: An inhalable pharmaceutical composition for pulmonary administration comprising human DNase I and a liquid carrier and, more particularly, but not exclusively, to methods, liquid pharmaceutical inhalation devices and systems for the therapeutic use thereof are provided.
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公开(公告)号：US10730925B2
公开(公告)日：2020-08-04
申请号：US16045848
申请日：2018-07-26
Applicant: Protalix Ltd.
Inventor： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Tami Ariel , Svetlana Gingis-Velitski
IPC: C07K14/705 , C07K14/715 , C12N5/04 , C12N5/14 , C12N15/09 , C12N15/62 , C12N15/63 , C12N15/82 , A61K36/81 , A61K38/17 , C07K14/525 , C07K14/415 , C12N5/10
Abstract: A plant produced chimeric polypeptide is provided. The plant produced chimeric polypeptide comprising: (i) a first domain which comprises a TNF Alpha binding domain of a TNF receptor, and (ii) a second domain which comprises an Fc domain of an immunoglobulin, wherein the first domain and the second domain are N-terminally to C-terminally respectively sequentially translationally fused and wherein the chimeric polypeptide specifically binds TNF Alpha.
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公开(公告)号：US09603907B2
公开(公告)日：2017-03-28
申请号：US14375485
申请日：2013-01-31
Applicant: Protalix Ltd.
Inventor： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Yulia Matiuhin , Liat Fux , Avidor Shulman
IPC: A61K38/46 , C12N9/22 , C12N9/82 , C12N15/82 , A61K9/00 , A61K38/47 , A61K33/06 , A61K45/06 , A61K9/14 , A61K33/14
CPC classification number: A61K38/465 , A61K9/007 , A61K9/0075 , A61K9/14 , A61K33/06 , A61K33/14 , A61K38/47 , A61K45/06 , C12N9/22 , C12N15/8221 , C12N15/8257 , C12Y301/21001 , C12Y302/01052
Abstract: DNase I formulations for pulmonary administration and, more particularly, but not exclusively, a dry powder formulation comprising, as an active ingredient, human DNase I, methods, dry powder inhalation devices and systems for the therapeutic use thereof are provided.
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公开(公告)号：US20150024050A1
公开(公告)日：2015-01-22
申请号：US14375485
申请日：2013-01-31
Applicant: Protalix Ltd.
Inventor： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Yulia Matiuhin , Liat Fux , Avidor Shulman
CPC classification number: A61K38/465 , A61K9/007 , A61K9/0075 , A61K9/14 , A61K33/06 , A61K33/14 , A61K38/47 , A61K45/06 , C12N9/22 , C12N15/8221 , C12N15/8257 , C12Y301/21001 , C12Y302/01052
Abstract: DNase I formulations for pulmonary administration and, more particularly, but not exclusively, a dry powder formulation comprising, as an active ingredient, human DNase I, methods, dry powder inhalation devices and systems for the therapeutic use thereof are provided.
Abstract translation: 提供了用于肺部给药的DNase I制剂，更具体地但不排他地提供了包含作为活性成分的人类DNase I，方法，干粉吸入装置和用于其治疗用途的系统的干粉制剂。
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9.发明申请DNASE I POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, METHODS OF PRODUCING DNASE I AND USES THEREOF IN THERAPY 审中-公开DNASE I多肽，编码其的多核苷酸，生产DNASE I的方法及其在治疗中的用途公开(公告)号：US20150010527A1
公开(公告)日：2015-01-08
申请号：US14375472
申请日：2013-01-31
Applicant: Protalix Ltd.
Inventor： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Yulia Matiuhin , Liat Fux , Avidor Shulman
CPC classification number: A61K38/465 , A61K9/007 , A61K9/0075 , A61K9/14 , A61K33/06 , A61K33/14 , A61K38/47 , A61K45/06 , C12N9/22 , C12N15/8221 , C12N15/8257 , C12Y301/21001 , C12Y302/01052
Abstract: Plant-expressed human recombinant DNase proteins, nucleic acid constructs for expression of the human recombinant DNase I in plant cells, cells expressing the nucleic acid construct and therapeutic uses thereof are disclosed. Particularly, compositions and methods for treating pulmonary and/or respiratory conditions by inhalation of the plant-expressed human recombinant DNase I are provided.
Abstract translation: 公开了植物表达的人重组DNA酶蛋白，用于在植物细胞中表达人重组DNase I的核酸构建体，表达核酸构建体的细胞及其治疗用途。 特别地，提供了通过吸入植物表达的人重组DNA酶I来治疗肺和/或呼吸病症的组合物和方法。
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