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公开(公告)号：US20170042140A1
公开(公告)日：2017-02-16
申请号：US15235613
申请日：2016-08-12
发明人： Peter Ghosh
IPC分类号： A01N1/02 , A61K35/28 , A61K31/737 , C12N5/077
CPC分类号： A01N1/0226 , A61K31/737 , A61K35/12 , A61K35/28 , C12N5/0655 , C12N5/0663 , C12N2501/90 , C12N2506/1346
摘要： The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.
摘要翻译： 本发明涉及多硫酸化多糖与祖细胞的组合，以改善祖细胞的活力，包括改善祖细胞的冷冻保存，并提供新的组合物，方法和用途。 本发明还涉及多硫酸化多糖调节祖细胞增殖和分化的用途。
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公开(公告)号：US20180206480A1
公开(公告)日：2018-07-26
申请号：US15861182
申请日：2018-01-03
发明人： Peter Ghosh
IPC分类号： A01N1/02 , C12N5/077 , A61K35/28 , A61K31/737 , C12N5/0775 , A61K35/12
CPC分类号： A01N1/0226 , A61K31/737 , A61K35/12 , A61K35/28 , C12N5/0655 , C12N5/0663 , C12N2501/90 , C12N2506/1346
摘要： The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.
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公开(公告)号：US09888679B2
公开(公告)日：2018-02-13
申请号：US15235613
申请日：2016-08-12
发明人： Peter Ghosh
IPC分类号： A61K31/737 , A01N1/02 , A61K35/28 , C12N5/0775 , C12N5/077 , A61K35/12
CPC分类号： A01N1/0226 , A61K31/737 , A61K35/12 , A61K35/28 , C12N5/0655 , C12N5/0663 , C12N2501/90 , C12N2506/1346
摘要： The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.
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公开(公告)号：US20240238330A1
公开(公告)日：2024-07-18
申请号：US18419108
申请日：2024-01-22
发明人： Peter Ghosh , Jack Edelman
IPC分类号： A61K31/737 , A61K9/00 , A61K9/48 , A61K31/196 , A61K31/365 , A61K31/415 , A61K31/42 , A61K31/444 , A61P19/02 , A61P29/00
CPC分类号： A61K31/737 , A61K9/0053 , A61K9/4816 , A61K31/196 , A61K31/365 , A61K31/415 , A61K31/42 , A61K31/444 , A61P19/02 , A61P29/00
摘要： Pharmaceutical and veterinary compositions for oral administration comprising a therapeutically effective amount of at least one coxib together with a therapeutically effective amount of pentosan polysulfate or a pharmaceutically acceptable salt thereof are described. The compositions have application for the prophylaxis or treatment of pain and/or inflammation. There is also described a pharmaceutical or vete1inal) composition comprising a therapeutically effective amount of at least one coxib. The compositions in at least some forms may be lactose free and/or provided in a non-gelatin capsule. Further, there are provided methods for administration of a therapeutically effective amount of at least one coxib in combination with pentosan polysulfate or a pharmaceutically acceptable salt thereof for the prophylaxis or treatment of pain and/or inflammation.
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