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公开(公告)号：US20230242557A9
公开(公告)日：2023-08-03
申请号：US17644969
申请日：2021-12-17
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein , Bradley Tait
IPC分类号： C07F7/18 , C07D401/14 , C07D401/06 , C07D403/06 , C07D471/04 , C07D209/12 , C07B59/00 , C07D209/14 , C07D417/14 , C07D519/00
CPC分类号： C07F7/1804 , C07D401/14 , C07D401/06 , C07D403/06 , C07D471/04 , C07D209/12 , C07B59/002 , C07D209/14 , C07D417/14 , C07D519/00 , C07B2200/05
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US11242361B2
公开(公告)日：2022-02-08
申请号：US16902019
申请日：2020-06-15
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein , Bradley Tait
IPC分类号： C07F7/18 , C07D401/14 , C07D401/06 , C07D403/06 , C07D471/04 , C07D209/12 , C07D209/14 , C07D417/14 , C07D519/00 , C07B59/00
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US11746098B2
公开(公告)日：2023-09-05
申请号：US17133362
申请日：2020-12-23
发明人： Matthew Cullen , Sheila Hauck , Megan Foley , Bradley Tait , Markus Haeberlein
IPC分类号： C07D401/06 , C07D207/333 , C07D207/335 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12
CPC分类号： C07D401/06 , C07D207/333 , C07D207/335 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12
摘要： The present invention is directed to compounds that inhibit Usp14, compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US20200308198A1
公开(公告)日：2020-10-01
申请号：US16902019
申请日：2020-06-15
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein , Bradley Tait
IPC分类号： C07F7/18 , C07D401/14 , C07D401/06 , C07D403/06 , C07D471/04 , C07D209/12 , C07B59/00 , C07D209/14 , C07D417/14 , C07D519/00
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US20180282352A1
公开(公告)日：2018-10-04
申请号：US15830261
申请日：2017-12-04
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein
IPC分类号： C07F7/18 , C07D209/14 , C07D417/14 , C07D519/00 , C07B59/00 , C07D401/14 , C07D209/12 , C07D471/04 , C07D403/06 , C07D401/06
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US20210188802A1
公开(公告)日：2021-06-24
申请号：US17133362
申请日：2020-12-23
发明人： Matthew Cullen , Sheila Hauck , Megan Foley , Bradley Tait , Markus Haeberlein
IPC分类号： C07D401/06 , C07D403/12 , C07D403/14 , C07D403/06 , C07D207/335 , C07D405/12 , C07D207/333
摘要： The present invention is directed to compounds that inhibit Usp14, compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US09850262B2
公开(公告)日：2017-12-26
申请号：US15153379
申请日：2016-05-12
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein
IPC分类号： C07F7/18 , C07D417/14 , C07D519/00 , C07B59/00 , C07D209/14 , C07D401/14 , C07D209/12 , C07D471/04 , C07D403/06 , C07D401/06
CPC分类号： C07F7/1804 , C07B59/002 , C07B2200/05 , C07D209/12 , C07D209/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D417/14 , C07D471/04 , C07D519/00
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US20220298181A1
公开(公告)日：2022-09-22
申请号：US17644969
申请日：2021-12-17
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein , Bradley Tait
IPC分类号： C07F7/18 , C07D401/14 , C07D401/06 , C07D403/06 , C07D471/04 , C07D209/12 , C07B59/00 , C07D209/14 , C07D417/14 , C07D519/00
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US20160333031A1
公开(公告)日：2016-11-17
申请号：US15153379
申请日：2016-05-12
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein
IPC分类号： C07F7/18 , C07D471/04 , C07D401/06 , C07D417/14 , C07B59/00 , C07D519/00 , C07D401/14 , C07D209/14 , C07D403/06
CPC分类号： C07F7/1804 , C07B59/002 , C07B2200/05 , C07D209/12 , C07D209/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D417/14 , C07D471/04 , C07D519/00
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
摘要翻译： 本发明涉及具有式（I），（II），（III），（IV）和（V）的化合物，其组合物，以及用于治疗与蛋白质降解功能障碍有关的病症的方法。
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