公开(公告)号：US10898331B2

公开(公告)日：2021-01-26

申请号：US15212947

申请日：2016-07-18

Applicant: Purdue Research Foundation

Inventor： Eric Nauman ,  Lia Antoaneta Stanciu ,  Michael J. Heiden ,  Madhi Dehestani

IPC: A61F2/28 ,  B22F3/11 ,  A61L27/04 ,  A61L27/56 ,  A61L27/12 ,  A61L27/58 ,  B22F3/24 ,  B22F5/10 ,  C22C38/04

Abstract: Bioresorbable porous biocomposites for orthopaedic applications. In an exemplary embodiment of a resorbable orthopaedic implant of the present disclosure, the implant comprises a porous alloy of at least a first metal and a second metal sintered together, the alloy configured to resorb into a body at substantially an atomic level without flaking off, wherein a porosity of the implant is defined by a first plurality of interconnected holes having a first range of sizes.

公开(公告)号：US20170107565A1

公开(公告)日：2017-04-20

申请号：US15297776

申请日：2016-10-19

Applicant: Purdue Research Foundation

Inventor： Esteban Ernesto Marinero-Caceres ,  Richard J. Kuhn ,  Lia Antoaneta Stanciu ,  Seon-Ah Jin

IPC: C12Q1/68 ,  G01N27/02 ,  G01N27/327 ,  C12Q1/70

CPC classification number: C12Q1/6837 ,  C12Q1/6825 ,  C12Q1/701 ,  G01N27/026 ,  G01N27/3276 ,  G01N27/3278 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/60 ,  C12Q2563/116 ,  C12Q2565/519 ,  C12Q2565/607

Abstract: In one embodiment, 3-Aminopropyltriethoxysilane (APTES) functionalized graphene oxide (APTES-GO) wrapped SiO2 particle composite (SiO2@APTES-GO) was prepared via the self-assembly process of APTES-GO sheets and SiO2 particles. Transmission electron microscopy (TEM) and Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy (ATR-FTIR) confirmed wrapping of the SiO2 particles by the APTES-GO sheets. A biosensor based on electrochemical impedance spectroscopy (EIS) was constructed and used to sensitively detect dengue DNA and dengue RNA via primer hybridization using different oligonucleotide sequences. The results demonstrated that the SiO2@APTES-GO electrode material led to enhanced sensitivity, selectivity and detection limit, compared to both APTES-GO and APTES-SiO2. The three-dimensional structure, high surface area, electrical properties and the ability for rapid hybridization offered by the SiO2@APTES-GO rendered this electrode material as ideal to use in the reported dengue impedimetric sensor.