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    LIGHT PIPE MICROSCOPE FOR LARGE-SCALE DYNAMIC IMAGING
    1.
    发明公开
    LIGHT PIPE MICROSCOPE FOR LARGE-SCALE DYNAMIC IMAGING 审中-公开

    公开(公告)号：US20240069321A1

    公开(公告)日：2024-02-29

    申请号：US18239829

    申请日：2023-08-30

    Applicant: Purdue Research Foundation

    Inventor： Meng Cui

    IPC: G02B21/36 ,  G01N21/64

    CPC classification number: G02B21/361 ,  G01N21/6458 ,  G01N2201/08

    Abstract: An apparatus for large-scale dynamic imaging of a sample is described. The apparatus includes an optical detector, a light guide, a dichroic beam splitter, and a light source. The light guide includes a first portion and a second portion. The second defines a tapered shape such that a first diameter defined by a distal end of the second portion is smaller than a second diameter defined by a proximal end of the second portion. The dichroic beam splitter is positioned between the first portion and the second portion of the light guide. The light source is configured to direct a light beam through an external surface of the dichroic beam splitter. The dichroic beam splitter is configured to direct the light beam toward the second open end of the light guide and transfer the return emitted signal through the light guide to the optical detector.

    GEOMETRIC TRANSFORMATION BASED OPTICAL SYSTEMS AND METHODS
    2.
    发明公开
    GEOMETRIC TRANSFORMATION BASED OPTICAL SYSTEMS AND METHODS 审中-公开

    公开(公告)号：US20230333368A1

    公开(公告)日：2023-10-19

    申请号：US18099122

    申请日：2023-01-19

    Applicant: Purdue Research Foundation

    Inventor： Meng Cui

    IPC: G02B27/00 ,  G02B3/00

    CPC classification number: G02B27/0031 ,  G02B3/0087 ,  G02B21/0028

    Abstract: An optical system includes first and second optical scanners and first and second gradient-index (GRIN) lenses. The first optical scanner is configured to scan a laser beam in a first scanning path and output a first scanned beam. The first GRIN lens is configured to translate the first scanned beam therethrough. The second optical scanner is configured to scan the first scanned beam in a second scanning path and output as second scanned beam. The second scanning path has a scanning trajectory rotated by 90 degrees relative to the first scanning path. The second GRIN lens is configured to translate the second scanned beam therethrough and collect the emitted signal from the imaging target.

    LINE SCANNING MECHANICAL STREAK SYSTEMS AND METHODS FOR PHOSPHORESCENCE LIFETIME IMAGING
    4.
    发明申请
    LINE SCANNING MECHANICAL STREAK SYSTEMS AND METHODS FOR PHOSPHORESCENCE LIFETIME IMAGING 有权

    公开(公告)号：US20220065783A1

    公开(公告)日：2022-03-03

    申请号：US17445945

    申请日：2021-08-25

    Applicant: Purdue Research Foundation

    Inventor： Meng Cui

    IPC: G01N21/64 ,  H04N5/225 ,  G06T11/00 ,  G06T11/20

    Abstract: Systems and methods for analyzing samples, such as tissue samples, and measuring the emissions when these samples are exposed to light are disclosed. Embodiments include illuminating multiple target locations on a sample with laser light, which may first be manipulated by a scanner, and receiving decaying emissions from the target location. At least some embodiments include the emissions traveling backwards along a substantial portion of the laser light pathway and being received by a detector. Additional embodiments include converting the received emissions into streak lines of position versus time, converting the streak lines to plots of signal strength versus time, and curve fitting the plots to determine representative decay times. In some embodiments, the decay times are presented as plots of position on the surface of the sample versus emission strength, which may be color coded. Some embodiment dwell on each target location for multiple scans of the laser.

    TUNABLE MECHANICAL RESONATOR FOR HIGH-PRECISION CUTTING OF BIOLOGICAL TISSUE
    6.
    发明公开
    TUNABLE MECHANICAL RESONATOR FOR HIGH-PRECISION CUTTING OF BIOLOGICAL TISSUE 审中-公开

    公开(公告)号：US20230236092A1

    公开(公告)日：2023-07-27

    申请号：US17957678

    申请日：2022-09-30

    Applicant: Purdue Research Foundation

    Inventor： Meng Cui

    IPC: G01N1/06

    CPC classification number: G01N1/06 ,  G01N2001/065 ,  G01N2001/063

    Abstract: Apparatuses for cutting tissue include an oscillator assembly and a clamp. The oscillator assembly defines a resonance frequency and includes a frame, an excitation element, and a blade. The frame has an upper portion and a lower portion, and the lower portion is configured to oscillate relative to the upper portion. The excitation element is coupled with the lower portion of the frame, and the excitation element is selectively operable to provide an excitation signal to the oscillator assembly sufficient to cause the oscillator assembly to oscillate at the resonance frequency. The blade is coupled with the lower portion for sectioning tissue. The clamp is selectively moveable along the frame to alter the resonance frequency of the oscillator assembly.

    Systems and methods for confocal microscopy
    7.
    发明授权
    Systems and methods for confocal microscopy 有权

    公开(公告)号：US12135411B2

    公开(公告)日：2024-11-05

    申请号：US17885728

    申请日：2022-08-11

    Applicant: Purdue Research Foundation

    Inventor： Meng Cui ,  Hehai Jiang

    IPC: G02B21/00 ,  G02B13/00 ,  G02B13/22 ,  G02B21/02 ,  G02B27/10 ,  G02B27/14

    Abstract: A confocal microscope system includes a light source configured to form a light beam, a scanning unit, and an objective lens. The scanning unit is in the form of a mechanically driven scanning unit with a controllable scanning trajectory, and is configured to direct the light beam through the scanning trajectory. The objective lens defines a pupil plane and a focal plane. The light beam is directed from the scanning unit to the objective lens. The confocal microscope system is configured for multi-color line-scanning confocal microscopy, and implements multi-color fluorescence imaging without laser excitation crosstalk.

    Line scanning mechanical streak systems and methods for phosphorescence lifetime imaging
    8.
    发明授权
    Line scanning mechanical streak systems and methods for phosphorescence lifetime imaging 有权

    公开(公告)号：US11815456B2

    公开(公告)日：2023-11-14

    申请号：US17445945

    申请日：2021-08-25

    Applicant: Purdue Research Foundation

    Inventor： Meng Cui

    IPC: G01N21/64 ,  G06T11/20 ,  G06T11/00 ,  H04N23/56

    CPC classification number: G01N21/6408 ,  G06T11/001 ,  G06T11/206 ,  H04N23/56 ,  G01N2201/06113 ,  G01N2201/1053

    Abstract: Systems and methods for analyzing samples, such as tissue samples, and measuring the emissions when these samples are exposed to light are disclosed. Embodiments include illuminating multiple target locations on a sample with laser light, which may first be manipulated by a scanner, and receiving decaying emissions from the target location. At least some embodiments include the emissions traveling backwards along a substantial portion of the laser light pathway and being received by a detector. Additional embodiments include converting the received emissions into streak lines of position versus time, converting the streak lines to plots of signal strength versus time, and curve fitting the plots to determine representative decay times. In some embodiments, the decay times are presented as plots of position on the surface of the sample versus emission strength, which may be color coded. Some embodiment dwell on each target location for multiple scans of the laser.

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