公开(公告)号：US20190025296A1

公开(公告)日：2019-01-24

申请号：US16040504

申请日：2018-07-19

Applicant: Purdue Research Foundation

Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

IPC: G01N33/547 ,  C07K16/18

Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

公开(公告)号：US10948489B2

公开(公告)日：2021-03-16

申请号：US16040504

申请日：2018-07-19

Applicant: Purdue Research Foundation

Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18 ,  C08L25/06

Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

公开(公告)号：US20220003760A1

公开(公告)日：2022-01-06

申请号：US17172078

申请日：2021-02-10

Applicant: Purdue Research Foundation

Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18

Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material, wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.