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    METHOD OF DETECTING A SUBSTANCE
    1.
    发明申请
    METHOD OF DETECTING A SUBSTANCE 有权

    公开(公告)号：US20220003760A1

    公开(公告)日：2022-01-06

    申请号：US17172078

    申请日：2021-02-10

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material, wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    NANOELECTROMECHANICAL RESONATORS
    5.
    发明申请
    NANOELECTROMECHANICAL RESONATORS 审中-公开
    纳米电子谐振器

    公开(公告)号：US20140203796A1

    公开(公告)日：2014-07-24

    申请号：US13968836

    申请日：2013-08-16

    Applicant: Purdue Research Foundation

    Inventor： Saeed Mohammadi ,  Hossein Pajouhi ,  Jeffrey Frederick Rhoads ,  Lin Yu

    IPC: H01L27/12 ,  G01R19/00 ,  H01L29/02

    CPC classification number: H01L27/1203 ,  B82Y10/00 ,  B82Y15/00 ,  H01L29/0673 ,  H01L29/16 ,  H01L29/775 ,  H03H3/0072 ,  H03H3/0073 ,  H03H9/02409 ,  H03H9/2463 ,  H03H2009/02314

    Abstract: A silicon device, e.g., a nanoelectromechanical resonator, has a silicon substrate; an oxide layer having a trench therein; a silicon device layer over the oxide layer; and a nanowire disposed at least partly over the trench. Substantially no oxide or polysilicon is over the nanowire in the trench. A polyimide layer over the silicon device layer includes an opening over the trench. A silicon device can include silicon-on-insulator layers and at least one complementary metal-oxide semiconductor transistor in addition to a nanowire substantially suspended over a trench. A system for measurement of a nanoresonator includes an AC source in series with the nanoresonator to provide an electrical signal thereto at a selected first frequency. Electrode(s) adjacent to and spaced apart from the nanoresonator are driven by voltage source. A detector detects a current through the nanoresonator.

    Abstract translation: 硅器件，例如纳米机电谐振器，具有硅衬底; 其中具有沟槽的氧化物层; 氧化物层上的硅器件层; 以及至少部分地布置在沟槽上的纳米线。 在沟槽中的纳米线上基本上没有氧化物或多晶硅。 硅器件层上的聚酰亚胺层包括在沟槽上的开口。 除了基本上悬在沟槽上的纳米线之外，硅器件可以包括绝缘体上硅层和至少一个互补金属氧化物半导体晶体管。 纳米谐振器的测量系统包括与纳米谐振器串联的AC源，以选定的第一频率向其提供电信号。 与纳米谐振器相邻并间隔开的电极由电压源驱动。 检测器检测通过纳米谐振器的电流。

    Method of detecting a substance
    7.
    发明授权
    Method of detecting a substance 有权

    公开(公告)号：US10948489B2

    公开(公告)日：2021-03-16

    申请号：US16040504

    申请日：2018-07-19

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18 ,  C08L25/06

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK
    9.
    发明申请
    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK 审中-公开

    公开(公告)号：US20200064310A1

    公开(公告)日：2020-02-27

    申请号：US16333273

    申请日：2018-12-04

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N29/12

    Abstract: This present disclosure relates to sensors capable of sensing mass, stiffness, and chemical or biological substances. More specifically, this disclosure provides the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates around at least 1 MHz.

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