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    Method of detecting a substance
    3.
    发明授权
    Method of detecting a substance 有权

    公开(公告)号：US10948489B2

    公开(公告)日：2021-03-16

    申请号：US16040504

    申请日：2018-07-19

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18 ,  C08L25/06

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK
    4.
    发明申请
    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK 审中-公开

    公开(公告)号：US20200064310A1

    公开(公告)日：2020-02-27

    申请号：US16333273

    申请日：2018-12-04

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N29/12

    Abstract: This present disclosure relates to sensors capable of sensing mass, stiffness, and chemical or biological substances. More specifically, this disclosure provides the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates around at least 1 MHz.

    METHOD OF DETECTING A SUBSTANCE
    5.
    发明申请
    METHOD OF DETECTING A SUBSTANCE 有权

    公开(公告)号：US20220003760A1

    公开(公告)日：2022-01-06

    申请号：US17172078

    申请日：2021-02-10

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material, wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    Nonlinear mass sensors based on electronic feedback
    6.
    发明授权
    Nonlinear mass sensors based on electronic feedback 有权

    公开(公告)号：US11060998B2

    公开(公告)日：2021-07-13

    申请号：US16333273

    申请日：2018-12-04

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N29/12 ,  G01N29/036

    Abstract: This present disclosure relates to sensors capable of sensing mass, stiffness, and chemical or biological substances. More specifically, this disclosure provides the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates around at least 1 MHz.

    METHOD OF DETECTING A SUBSTANCE
    8.
    发明申请
    METHOD OF DETECTING A SUBSTANCE 审中-公开

    公开(公告)号：US20190025296A1

    公开(公告)日：2019-01-24

    申请号：US16040504

    申请日：2018-07-19

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/547 ,  C07K16/18

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK AND METHODS OF USING THE SAME
    9.
    发明申请
    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK AND METHODS OF USING THE SAME 有权
    基于电子反馈的非线性质量传感器及其使用方法

    公开(公告)号：US20160290855A1

    公开(公告)日：2016-10-06

    申请号：US14973262

    申请日：2015-12-17

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  George Tsu-Chih Chiu ,  Nikhil Bajaj ,  Andrew Burke Sabater

    IPC: G01H13/00

    CPC classification number: G01H13/00 ,  G01L9/00 ,  G01P15/00 ,  G01P15/097

    Abstract: A device and method for sensing including a sensor having a functional surface layer located to interact with a material to be sensed, the sensor having an output that produces a signal responsive one or more of inertia, stiffness, acceleration, pressure, radiation, chemical compounds, and biological compounds; and further including electronics including: an input coupled to the sensor to receive a first signal therefrom; and a non-linearity provider that applies one or more non-linear operations to the input signal to generate a non-linear second signal.

    Abstract translation: 一种用于感测的装置和方法，包括具有功能表面层的传感器，所述功能表面层定位成与要感测的材料相互作用，所述传感器具有产生响应惯性，刚度，加速度，压力，辐射，化学化合物中的一种或多种的信号 ，和生物化合物; 并且还包括电子器件，包括：耦合到所述传感器以从其接收第一信号的输入; 以及向输入信号施加一个或多个非线性运算以产生非线性第二信号的非线性提供器。

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