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    METHOD OF DETECTING A SUBSTANCE
    1.
    发明申请
    METHOD OF DETECTING A SUBSTANCE 审中-公开

    公开(公告)号：US20190025296A1

    公开(公告)日：2019-01-24

    申请号：US16040504

    申请日：2018-07-19

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/547 ,  C07K16/18

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    Method of detecting a substance
    5.
    发明授权
    Method of detecting a substance 有权

    公开(公告)号：US10948489B2

    公开(公告)日：2021-03-16

    申请号：US16040504

    申请日：2018-07-19

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18 ,  C08L25/06

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    Therapeutic Method and Apparatus Using Mechanically Induced Vibration
    6.
    发明申请
    Therapeutic Method and Apparatus Using Mechanically Induced Vibration 审中-公开
    使用机械诱导振动的治疗方法和装置

    公开(公告)号：US20160022536A1

    公开(公告)日：2016-01-28

    申请号：US14877900

    申请日：2015-10-07

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Eric A. Nauman ,  Jonathan M. Childress ,  Anne Dye Zakrajsek ,  James A. Isca ,  Daniel J. Rawson ,  Andrew J. Zakrajsek

    IPC: A61H23/02

    CPC classification number: A61H23/0263 ,  A61H23/02 ,  A61H2201/164 ,  A61H2201/1647 ,  A61H2201/1654 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/5046 ,  A61H2205/06 ,  A61H2205/10

    Abstract: A noninvasive method of treating or preventing pressure ulcers is disclosed. The method includes placing a motorized pad about a subject, activating a plurality of motors positioned in the motorized pad each having an output shaft to thereby cause application of a rotational motion to each of the plurality of motor shafts, converting the rotational motion to a vibrational motion by using a corresponding unbalanced mass with each motor, applying the vibrational motion to a corresponding part of the subject, and damping any vibrational forces substantially parallel to an underlying skin surface more than vibrational forces substantially perpendicular to the underlying skin surface.

    Abstract translation: 公开了一种治疗或预​​防压力性溃疡的非侵入性方法。 该方法包括将电动垫围绕被摄体放置，激活定位在电动垫中的多个电动机，每个电机具有输出轴，从而使多个电动机轴中的每个电动机轴上的转动运动，将旋转运动转换成振动 通过使用与每个马达相对应的不平衡质量运动，将振动运动施加到受试者的对应部分，并且阻尼基本上平行于下面的皮肤表面的任何振动力大于基本垂直于下面的皮肤表面的振动力。

    METHOD OF DETECTING A SUBSTANCE
    7.
    发明申请
    METHOD OF DETECTING A SUBSTANCE 有权

    公开(公告)号：US20220003760A1

    公开(公告)日：2022-01-06

    申请号：US17172078

    申请日：2021-02-10

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material, wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    Therapeutic Method and Apparatus Using Mechanically Induced Vibration
    9.
    发明申请
    Therapeutic Method and Apparatus Using Mechanically Induced Vibration 审中-公开
    使用机械诱导振动的治疗方法和装置

    公开(公告)号：US20140316311A1

    公开(公告)日：2014-10-23

    申请号：US14321616

    申请日：2014-07-01

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Eric A. Nauman ,  Jonathan M. Childress ,  Anne Dye Zakrajsek ,  James A. Isca ,  Daniel J. Rawson ,  Andrew J. Zakrajsek

    IPC: A61H23/02

    CPC classification number: A61H23/0263 ,  A61H23/02 ,  A61H2201/164 ,  A61H2201/1647 ,  A61H2201/1654 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/5046 ,  A61H2205/06 ,  A61H2205/10

    Abstract: A sleeve that provides mechanical stimulation to the arm to prevent bone density loss. A primary goal of this product is to prevent bone density loss that occurs during extended space travel. For one embodiment, only the predefined frequency specifications had to be met (between 40 Hz and 60 Hz). By meeting these frequencies for a duration of 30 minutes the product will theoretically prevent the loss of bone density. Additionally, clinical trials will need to be conducted before this product can be marketed. The product includes of several mechanical vibrators attached to a sleeve. The vibrators are small unbalanced-mass motors which are similar to those found in cell phones. The motors are encased in dome shaped housings designed to reduce lateral vibrations along the arm. The product is controlled using an Arduino board attached to the sleeve that actuates the motors.

    Abstract translation: 提供机械刺激手臂以防止骨密度损失的袖子。 该产品的主要目标是防止在延长空间行驶期间发生的骨密度损失。 对于一个实施例，仅需要满足预定义的频率规格（在40Hz和60Hz之间）。 通过满足这些频率持续30分钟，产品理论上可以防止骨密度的损失。 此外，临床试验需要在本产品上市之前进行。 该产品包括几个连接到套筒上的机械振动器。 振动器是与手机中发现的相似的小型不平衡质量马达。 电动机被包围在圆顶形的外壳中，旨在减少沿着手臂的横向振动。 该产品使用连接到套筒上的Arduino板进行控制，以驱动电机。

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