公开(公告)号：US11109763B2

公开(公告)日：2021-09-07

申请号：US15998889

申请日：2017-02-13

申请人： PURDUE RESEARCH FOUNDATION

发明人： Ji-xin Cheng ,  Pu Wang ,  Yingchun Cao ,  Jie Hui

IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B5/02 ,  A61B8/12 ,  A61M25/00

摘要： A photoacoustic catheter includes an elongated catheter body and a housing positioned near a distal end of the elongated catheter body. A length of multimode fiber extends through the elongated catheter body and has a distal end that is beveled at about 45° relative to a longitudinal axis of the multimode fiber and is positioned in the housing. An ultrasonic transducer, electrically connected to an electrical wire extending along the elongated catheter body, is positioned within the housing. A mirror element is also positioned within the housing and includes a mirror surface beveled at about 45° relative to the longitudinal axis of the multimode fiber. The catheter is operable to deliver an optical wave through the multimode fiber and to deliver an ultrasonic wave collinearly from the housing and out of an aperture of the housing to obtain optical data and ultrasonic data within a mammalian luminal organ.

公开(公告)号：US11083437B2

公开(公告)日：2021-08-10

申请号：US15772630

申请日：2016-11-02

申请人： Purdue Research Foundation

发明人： Ji-xin Cheng ,  Pu Wang ,  Lu Lan ,  Rui Li

IPC分类号： A61B8/08 ,  A61B8/00 ,  A61B5/00

摘要： A multimodal ultrasound/photoacoustic tumor margin detection system. The system can be comprised of an imaging and system control console, which can include an ultrasound and data acquisition subsystem including an ultrasound transmitter and receiver configured to transmit and receive ultrasonic energy. A host-control computer configured to provide a function generator function and a delay generation function can also be a part of the imaging and system control console.

公开(公告)号：US20190117197A1

公开(公告)日：2019-04-25

申请号：US15772630

申请日：2016-11-02

申请人： Purdue Research Foundation

发明人： Ji-xin Cheng ,  Pu Wang ,  Lu Lan ,  Rui LI

IPC分类号： A61B8/08 ,  A61B5/00 ,  A61B8/00

摘要： A multimodal ultrasound/photoacoustic tumor margin detection system. The system can be comprised of an imaging and system control console, which can include an ultrasound and data acquisition subsystem including an ultrasound transmitter and receiver configured to transmit and receive ultrasonic energy. A host-control computer configured to provide a function generator function and a delay generation function can also be a part of the imaging and system control console.

公开(公告)号：US11666224B2

公开(公告)日：2023-06-06

申请号：US15774070

申请日：2016-11-07

申请人： Purdue Research Foundation

发明人： Ji-xin Cheng ,  Pu Wang ,  Lu Lan ,  Yan Xia ,  Ke Huo

IPC分类号： A61B5/00 ,  A61B90/00 ,  A61B5/06 ,  A61B34/20 ,  A61B17/32 ,  A61B17/3205 ,  A61B17/50 ,  A61B8/08 ,  A61B90/30 ,  A61B90/50 ,  A61B17/00 ,  G01N33/48

CPC分类号： A61B5/0095 ,  A61B5/061 ,  A61B5/4836 ,  A61B5/6851 ,  A61B5/743 ,  A61B17/3205 ,  A61B17/320016 ,  A61B34/20 ,  A61B90/36 ,  A61B90/37 ,  G01N33/48 ,  A61B5/064 ,  A61B5/7445 ,  A61B8/0825 ,  A61B17/50 ,  A61B2017/008 ,  A61B2017/00707 ,  A61B2034/2057 ,  A61B2090/306 ,  A61B2090/365 ,  A61B2090/378 ,  A61B2090/502

摘要： A lesion detection system for use with a patient, comprising an optoacoustic guide wire assembly configured to be insertable into a patient's tissue. The optical acoustic guide wire assembly can be comprised of an optical waveguide have a first end and a second end, a light source coupled to the second end of the optical waveguide, wherein said light source configured to emit energy to the patient's tissue, at least one transducer configured to detect an ultrasound signal emitted from the patient's tissue in response to energy emitted from the light source, and a computer system.

公开(公告)号：US10928324B2

公开(公告)日：2021-02-23

申请号：US16470119

申请日：2017-12-14

申请人： Purdue Research Foundation ,  Chien-Sheng Liao ,  Pu Wang ,  Ji-Xin Cheng

发明人： Chien-Sheng Liao ,  Pu Wang ,  Ji-Xin Cheng

IPC分类号： G01J3/44 ,  G01N21/65 ,  G01J3/10 ,  G01J3/433

摘要： A microsecond-scale stimulated Raman spectroscopic imaging system having a light source, such as a laser output that provides two femtosecond laser beams and a modulator to modulate the laser intensity at frequency between about 1 and about 100 megahertz. The system can further include a medium that chirps the two femtosecond beams to generate a spectral focus in a specimen, and a galvo mirror or resonant mirror pair to scan the two femtosecond beams in two dimension on the specimen. An objective lens can focus the two laser beams into a specimen or sample and a resonant delay scanner configured to produce an optical delay to the pair of chirped beams in said specimen and a tuned amplifier or lock-in amplifier can be used to extract the stimulated Raman-signal shift at the aforementioned modulation frequency.

公开(公告)号：US20180310831A1

公开(公告)日：2018-11-01

申请号：US15774070

申请日：2016-11-07

申请人： Purdue Research Foundation

发明人： Ji-xin Cheng ,  Pu Wang ,  Lu Lan ,  Yan Xia ,  Ke Huo

IPC分类号： A61B5/00 ,  A61B17/32 ,  A61B17/3205 ,  A61B34/20 ,  A61B90/00

CPC分类号： A61B5/4836 ,  A61B5/0095 ,  A61B5/061 ,  A61B5/064 ,  A61B5/6851 ,  A61B5/743 ,  A61B5/7445 ,  A61B8/0825 ,  A61B17/50 ,  A61B34/20 ,  A61B90/36 ,  A61B2017/00707 ,  A61B2034/2057 ,  A61B2090/306 ,  A61B2090/365 ,  A61B2090/378 ,  A61B2090/502 ,  G01N33/48

摘要： A lesion detection system for use with a patient, comprising an optoacoustic guide wire assembly configured to be insertable into a patient's tissue. The optical acoustic guide wire assembly can be comprised of an optical waveguide have a first end and a second end, a light source coupled to the second end of the optical waveguide, wherein said light source configured to emit energy to the patient's tissue, at least one transducer configured to detect an ultrasound signal emitted from the patient's tissue in response to energy emitted from the light source, and a computer system.