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公开(公告)号：US20230280360A1
公开(公告)日：2023-09-07
申请号：US18316402
申请日：2023-05-12
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , Y10T436/25375 , Y10T436/25 , Y10T436/25125 , G16B99/00
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US09791464B2
公开(公告)日：2017-10-17
申请号：US14726802
申请日：2015-06-01
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US09046539B2
公开(公告)日：2015-06-02
申请号：US14226089
申请日：2014-03-26
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译： 本发明提供了利用差示带电粒子迁移率分析方法从生物样品制备脂蛋白的方法，包括HDL，LDL，Lp（a），IDL和VLDL，用于诊断目的。 还提供了通过差示带电粒子迁移率分析脂蛋白的大小分布的方法，该脂蛋白通过本发明的方法制备。 还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。
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公开(公告)号：US20180011117A1
公开(公告)日：2018-01-11
申请号：US15711778
申请日：2017-09-21
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16B99/00 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US20210181217A1
公开(公告)日：2021-06-17
申请号：US17188855
申请日：2021-03-01
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US10948503B2
公开(公告)日：2021-03-16
申请号：US16281584
申请日：2019-02-21
发明人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US20190187160A1
公开(公告)日：2019-06-20
申请号：US16281584
申请日：2019-02-21
发明人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16B99/00 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US20140287530A1
公开(公告)日：2014-09-25
申请号：US14226089
申请日：2014-03-26
发明人： Michael P. Caulfield , Richard E. Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译： 本发明提供了利用差示带电粒子迁移率分析方法从生物样品制备脂蛋白的方法，包括HDL，LDL，Lp（a），IDL和VLDL，用于诊断目的。 还提供了通过差示带电粒子迁移率分析脂蛋白的大小分布的方法，该脂蛋白通过本发明的方法制备。 还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。
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公开(公告)号：US12055554B2
公开(公告)日：2024-08-06
申请号：US18316402
申请日：2023-05-12
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , G16B99/00 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US11680949B2
公开(公告)日：2023-06-20
申请号：US17188855
申请日：2021-03-01
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , G16B99/00 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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