-
公开(公告)号：US12066446B2
公开(公告)日：2024-08-20
申请号：US18142153
申请日：2023-05-02
发明人： Brett Holmquist , Nigel Clarke , Anne Caston , Richard E. Reitz
IPC分类号： G01N33/82
CPC分类号： G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
摘要： Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
-
公开(公告)号：US11921122B2
公开(公告)日：2024-03-05
申请号：US18107947
申请日：2023-02-09
CPC分类号： G01N33/82 , G01N30/7233 , G01N30/72 , G01N2030/8813 , G01N2030/8822 , G01N2458/15 , G01N2560/00 , H01J49/00 , H01J49/004 , Y10T436/20 , Y10T436/203332 , Y10T436/24
摘要： Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
-
公开(公告)号：US11852636B2
公开(公告)日：2023-12-26
申请号：US18091726
申请日：2022-12-30
发明人： Brett Holmquist , Nigel Clarke
CPC分类号： G01N33/82 , G01N30/7233 , H01J49/004 , H01J49/145 , G01N2030/009 , G01N2030/027 , G01N2030/8813
摘要： The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
-
公开(公告)号：US20230280360A1
公开(公告)日：2023-09-07
申请号：US18316402
申请日：2023-05-12
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , Y10T436/25375 , Y10T436/25 , Y10T436/25125 , G16B99/00
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
-
公开(公告)号：US11650216B2
公开(公告)日：2023-05-16
申请号：US16748234
申请日：2020-01-21
发明人： Brett Holmquist , Nigel Clarke , Anne Caston , Richard E. Reitz
CPC分类号： G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
摘要： Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
-
公开(公告)号：US11624737B2
公开(公告)日：2023-04-11
申请号：US17839298
申请日：2022-06-13
摘要： Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
-
公开(公告)号：US11549954B2
公开(公告)日：2023-01-10
申请号：US17700320
申请日：2022-03-21
发明人： Brett Holmquist , Nigel Clarke
摘要： The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
-
公开(公告)号：US20220308021A1
公开(公告)日：2022-09-29
申请号：US17839298
申请日：2022-06-13
IPC分类号： G01N30/72 , G01N33/94 , H01J49/00 , H01J49/26 , G01N33/487
摘要： Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
-
公开(公告)号：US20220291228A1
公开(公告)日：2022-09-15
申请号：US17827333
申请日：2022-05-27
发明人： Nigel CLARKE , Zhaohui CHEN
IPC分类号： G01N33/68 , G01N33/487 , G01N30/72 , G01N33/74 , H01J49/04 , C07K14/625 , C07K1/16 , B01D15/08 , C07K1/14 , C07K14/62 , G01N33/543
摘要： Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
-
公开(公告)号：US11162142B2
公开(公告)日：2021-11-02
申请号：US15952436
申请日：2018-04-13
发明人： Wanlong Ma
IPC分类号： C12Q1/68 , C12Q1/6886
摘要： The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the bcr-abl1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib.
-
-
-
-
-
-
-
-
-
搜索结果
375 条记录 (耗时 0.03 秒)
