公开(公告)号：US06205645B1

公开(公告)日：2001-03-27

申请号：US08652624

申请日：1996-05-21

申请人： Qi Li ,  Craig J. Christopherson ,  Gilbert N. Riley, Jr. ,  William L. Carter ,  William J. Michels ,  Eric R. Podtburg ,  Lawrence J. Masur

发明人： Qi Li ,  Craig J. Christopherson ,  Gilbert N. Riley, Jr. ,  William L. Carter ,  William J. Michels ,  Eric R. Podtburg ,  Lawrence J. Masur

IPC分类号： H01L3924

CPC分类号： H01L39/248 ,  Y10T29/49014

摘要： The combination of one or more high reduction drafts with controlled, low back tensions increases the range of deformation conditions over which dimensional tolerances and Je may be optimized. The method comprises the steps of: first, providing a precursor article comprising a metal matrix surrounding a plurality of filaments extending along the length of the article and comprising precursors to a desired superconducting ceramic; next, roll working the precursor article during a breakdown stage at a back tension less than the elastic to plastic transition threshold of the composite during at least one high reduction roll working draft, and, then, sintering the rolled article to obtain the desired superconducting ceramic. In a preferred embodiment, the rolling step further comprises rolling the article at a front tension less than the elastic to plastic transition threshold of the rolled, unsintered article.

摘要翻译： 一个或多个高减速牵引力与受控的低回力张力的组合增加了尺寸公差和Je可能被优化的变形条件的范围。 该方法包括以下步骤：首先，提供包含金属基体的前体制品，所述金属基质围绕沿着所述制品的长度延伸的多根长丝，并且包括所需超导陶瓷的前体; 接下来，在至少一个高还原辊工作牵伸期间，以小于复合材料的弹性 - 塑性转变阈值的后拉力在击穿阶段期间辊加工前体制品，然后烧结轧制制品以获得所需的超导陶瓷 。 在优选实施例中，轧制步骤还包括以低于轧制未烧结制品的弹性 - 塑性转变阈值的前拉力滚动制品。

公开(公告)号：US06370762B1

公开(公告)日：2002-04-16

申请号：US08651688

申请日：1996-05-21

申请人： Qi Li ,  Theodore S. Greene ,  Gilbert N. Riley, Jr. ,  William J. Michels ,  William L. Carter

发明人： Qi Li ,  Theodore S. Greene ,  Gilbert N. Riley, Jr. ,  William J. Michels ,  William L. Carter

IPC分类号： H01L3924

CPC分类号： H01L39/248 ,  Y10T29/49014

摘要： A reduced coefficient of friction, preferably created by ideal lubrication conditions, may advantageously be employed in the breakdown deformation of a precursor to a multifilamentary superconducting composite, particularly in combination with one or more high reduction breakdown drafts, to improve composite homogeneity and significantly increase the range of deformation conditions over which dimensional tolerances and Je may be optimized. Precursor composites made by this method exhibit reduced microhardness variability and fewer and less serious transverse filament defects than composites made by prior art methods. The method comprises the steps of: first, providing a precursor article comprising a metal matrix surrounding a plurality of filaments extending along the length of the article and comprising precursors to a desired superconducting ceramic; next, roll working the precursor article during a breakdown stage at a predetermined pressure and a coefficient of friction less than about 0.2, preferably less than 0.01, and preferably less than about 0.001 during each roll working draft, and, then, sintering the rolled article to obtain the desired superconducting ceramic. The coefficient of friction is preferably obtained by interposing a lubricant between the precursor article and one or more rolls, most preferably under conditions which create ideal lubrication conditions.

摘要翻译： 优选地，通过理想的润滑条件产生的减小的摩擦系数可以有利地用于前体与多丝超导复合材料的击穿变形，特别是与一种或多种高还原击穿气流组合，以提高复合材料均匀性并显着增加 尺寸公差和Je可以优化的变形条件范围。 通过该方法制备的前体复合材料显示出比现有技术方法制备的复合材料显微硬度变化性和越来越少的横向丝缺陷。 该方法包括以下步骤：首先，提供包含金属基体的前体制品，所述金属基质围绕沿着所述制品的长度延伸的多根长丝，并且包括所需超导陶瓷的前体; 接下来，在每个轧制工作牵伸期间以预定压力和摩擦系数小于约0.2，优选小于0.01，优选小于约0.001的击穿阶段对前体制品进行辊加工，然后烧结轧制制品 以获得所需的超导陶瓷。 摩擦系数优选通过在前体制品和一个或多个辊之间插入润滑剂，最优选在产生理想的润滑条件的条件下来获得。

公开(公告)号：US5798318A

公开(公告)日：1998-08-25

申请号：US651169

申请日：1996-05-21

申请人： Qi Li ,  William J. Michels ,  Ronald D. Parrella ,  Gilbert N. Riley, Jr. ,  Mark D. Teplitsky ,  Steven Fleshler

发明人： Qi Li ,  William J. Michels ,  Ronald D. Parrella ,  Gilbert N. Riley, Jr. ,  Mark D. Teplitsky ,  Steven Fleshler

IPC分类号： C01G1/00 ,  C01G15/00 ,  C01G21/00 ,  C01G30/00 ,  H01B12/04 ,  H01B13/00 ,  H01L39/24 ,  H01B12/02

CPC分类号： H01L39/248 ,  H01L39/2419 ,  Y10S505/742

摘要： The present invention provides a (Bi,Pb)SCCO-2223 oxide superconductor composite which exhibits improved critical current density and critical current density retention in the presence of magnetic fields. Retention of critical current density in 0.1 T fields (77 K, .perp. ab plane) of greater than 35% is disclosed. Significant improvements in oxide superconductor wire current carrying capacity in a magnetic field are obtained by subjecting the oxide superconductor composite to a post-processing heat treatment which reduces the amount of lead in the (Bi,Pb)SCCO-2223 phase and forms a lead-rich non-superconducting phase. The heat treatment is carried out under conditions which localize the lead-rich phase at high energy sites in the composite.

摘要翻译： 本发明提供了一种（Bi，Pb）SCCO-2223氧化物超导体复合材料，其在磁场存在下表现出改善的临界电流密度和临界电流密度保持。 公开了0.1T场（77K，ORTHOGONAL ab平面）中临界电流密度的保持率大于35％。 通过对氧化物超导体复合物进行后处理热处理，可以减少（Bi，Pb）SCCO-2223相中的铅的量，并形成铅 - 丰富的非超导相。 热处理在复合材料中在高能量位置使富铅相定位的条件下进行。

公开(公告)号：US06188920B1

公开(公告)日：2001-02-13

申请号：US09137733

申请日：1998-08-21

申请人： Qi Li ,  William J. Michels ,  Ronald D. Parrella ,  Gilbert N. Riley, Jr. ,  Mark D. Teplitsky ,  Steven Fleshler

发明人： Qi Li ,  William J. Michels ,  Ronald D. Parrella ,  Gilbert N. Riley, Jr. ,  Mark D. Teplitsky ,  Steven Fleshler

IPC分类号： H01B1200

CPC分类号： H01L39/248 ,  H01L39/2419 ,  Y10S505/742

摘要： The present invention provides a (Bi,Pb)SCCO-2223 oxide superconductor composite which exhibits improved critical current density and critical current density retention in the presence of magnetic fields. Retention of critical current density in 0.1 T fields (77 K, ⊥ ab plane) of greater than 35% is disclosed. Significant improvements in oxide superconductor wire current carrying capacity in a magnetic field are obtained by subjecting the oxide superconductor composite to a post-processing heat treatment which reduces the amount of lead in the (Bi,Pb)SCCO-2223 phase and forms a lead-rich non-superconducting phase. The heat treatment is carried out under conditions which localize the lead-rich phase at high energy sites in the composite.

摘要翻译： 本发明提供了一种（Bi，Pb）SCCO-2223氧化物超导体复合材料，其在磁场存在下表现出改善的临界电流密度和临界电流密度保持。 公开了0.1T场（77K，⊥ab平面）中临界电流密度的保持率大于35％。 通过对氧化物超导体复合物进行后处理热处理，可以减少（Bi，Pb）SCCO-2223相中的铅的量，并形成铅 - 丰富的非超导相。 热处理在复合材料中在高能量位置使富铅相定位的条件下进行。

公开(公告)号：US10920243B1

公开(公告)日：2021-02-16

申请号：US12807274

申请日：2010-08-31

申请人： William J. Michels

发明人： William J. Michels

IPC分类号： C12N15/85

摘要： Methods for elucidating biopolymer interactions with known and/or unknown small molecules (e.g. candidate drug compounds) are disclosed. These methods utilize novel (usually motile) organisms transformed with one or more heterologous biopolymer sequences. Biopolymer expression is promoted in cells mediating movement in said organism, generally dually-promoted in paired sets of cells mediating oppositely-directed movement. Modulation of motility in the resultant organism due to the presence of small molecules demonstrates small molecule interaction with said natural and/or mutated biopolymer. Analyzed in a chemical gradient, one or more interacting small molecule species can be identified by oriented migration, even in the presence of one or more non-interacting small molecule species. A competing and/or interfering biopolymer can be introduced without obscuring the motility signal. Methods described herein have utility for the discovery of novel therapeutic compounds (drug discovery), for the improvement of existing therapeutic compounds (drug refinement), and for the precise identification of small molecule binding sites on biopolymers via mutagenesis (structural elucidation). A specific embodiment, a Nematode Olfaction-based Structural Elucidation (NOSE) assay, is described herein.

公开(公告)号：US5872241A

公开(公告)日：1999-02-16

申请号：US378235

申请日：1995-01-25

申请人： Anna M. Pyle ,  William J. Michels

发明人： Anna M. Pyle ,  William J. Michels

IPC分类号： A01K67/027 ,  A61K38/00 ,  C12N15/113 ,  C07H21/00 ,  C07H21/02 ,  C12P19/34 ,  C12Q1/68

CPC分类号： A01K67/0275 ,  C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/124

摘要： This invention is directed to a composition for catalyzed oligonucleotide cleavage comprising a synthetic non-naturally occurring oligonucleotide compound. The compound comprises nucleotides whose sequence defines a conserved group II intron catalytic region and nucleotides whose sequence is capable of hybridizing with a predetermined oligonucleotide target sequence to be cleaved, such target sequence not being present within the compound. The composition also includes an appropriate oligonucleotide co-factor. Preferably, the conserved group II intron catalytic region is a group II intron domain I catalytic region. In one embodiment the conserved group II intron domain I catalytic region may further comprise a conserved portion of a group II intron domain II, a group II intron domain III, a group II intron domain IV, a group II intron domain V, or a group II intron domain VI. The invention is also directed to methods of treatment and methods of use of such compounds.

摘要翻译： 本发明涉及包含合成非天然存在的寡核苷酸化合物的催化寡核苷酸切割的组合物。 该化合物包含其序列定义保守的第II组内含子催化区域的核苷酸和其序列能够与要切割的预定寡核苷酸靶序列杂交的核苷酸，该目标序列不存在于该化合物内。 该组合物还包括合适的寡核苷酸辅因子。 优选地，保守的II组内含子催化区是II组内含子结构域I催化区。 在一个实施方案中，保守II组内含子结构域I催化区可进一步包含II组内含子结构域II，II组内含子结构域III，II组内含子结构域IV，II组内含子结构域V或组 II内含子结构域VI。 本发明还涉及治疗方法和这些化合物的使用方法。