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1.
公开(公告)号:US20110263647A1
公开(公告)日:2011-10-27
申请号:US13130255
申请日:2010-01-13
申请人: Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , David J. ST. Jean, JR. , Andreas Reichelt , Qingyian Liu , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Carl D. Davis , Matthew P. Bourbeau , Kate S. Ashton , John G. Allen
发明人: Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , David J. ST. Jean, JR. , Andreas Reichelt , Qingyian Liu , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Carl D. Davis , Matthew P. Bourbeau , Kate S. Ashton , John G. Allen
IPC分类号: A61K31/4709 , C07D417/14 , A61P35/00 , C07D417/04
CPC分类号: C07D417/14 , C07D417/04
摘要: The invention relates to thiazole compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译: 本发明涉及式I的噻唑化合物及其组合物,其用于治疗由蛋白激酶B(PKB)介导的疾病,其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长,癌症,炎症和代谢紊乱相关的疾病的治疗用途。