公开(公告)号：US20080279920A1

公开(公告)日：2008-11-13

申请号：US11792179

申请日：2005-11-04

申请人： Qingquan Tang ,  Patrick Y. Lu ,  Frank Y. Xie ,  Martin C. Woodle ,  Bojian Zheng

发明人： Qingquan Tang ,  Patrick Y. Lu ,  Frank Y. Xie ,  Martin C. Woodle ,  Bojian Zheng

IPC分类号： A61K31/7105 ,  A61K31/711 ,  C12N15/31 ,  C12N15/85 ,  C12N5/10 ,  A61K9/127 ,  A61P31/16

CPC分类号： A61K31/711 ,  A61K31/7105 ,  C12N15/1131 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2760/16111 ,  C12N2760/18511

摘要： The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.

摘要翻译： 本发明提供干扰呼吸道病毒感染（包括呼吸道合胞病毒和禽流感A）包括H5N1毒株在内的病毒复制的siRNA组合物。 本发明还提供siRNA组合物用于抑制呼吸道病毒感染细胞中病毒基因表达的用途，以及用于治疗受试者中的呼吸道病毒感染的用途。 本发明通常提供多核苷酸，其包含15至30个碱基的第一核苷酸序列，其靶向呼吸道合胞病毒或甲型流感病毒的基因组，其补体，双链多核苷酸或发夹多核苷酸。 另外，本发明提供了含有siRNA序列的载体，细胞和药物组合物。

公开(公告)号：US20110124710A1

公开(公告)日：2011-05-26

申请号：US13005688

申请日：2011-01-13

申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

IPC分类号： C07H21/02 ,  A61K31/7105 ,  C12N5/09 ,  A61P35/04

CPC分类号： A61K31/70 ,  A61K9/5146 ,  A61K48/00

摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

公开(公告)号：US07534878B2

公开(公告)日：2009-05-19

申请号：US11824085

申请日：2007-06-29

申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00

CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5146 ,  A61K31/70 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/32

摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

公开(公告)号：US07786092B2

公开(公告)日：2010-08-31

申请号：US12420907

申请日：2009-04-09

申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5146 ,  A61K31/70 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/32

摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

公开(公告)号：US20110038849A1

公开(公告)日：2011-02-17

申请号：US12519944

申请日：2006-12-21

申请人： Frank Y. Xie ,  Patrick Y. Lu ,  Martin C. Woodle ,  Yijia Liu

发明人： Frank Y. Xie ,  Patrick Y. Lu ,  Martin C. Woodle ,  Yijia Liu

IPC分类号： A61K39/395 ,  C07H21/04 ,  A61K31/7088 ,  C12N5/02 ,  C07K16/00 ,  A61P35/00

CPC分类号： C12N15/1135 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2330/30

摘要： Compositions and methods for treating diseases, such as cancers. The compositions are effective to silence, down-regulate or suppress the expression of a validated target gene by stimulating the process of RNA interference of gene expression, thus inhibiting tumor growth. The invention also provides methods for treating diseases, such as cancers, by inactivation of a validated target gene product, using neutralizing antibody or small molecule drug, to inhibit tumor growth. More particularly, the compositions and methods are directed toward a cancer or a precancerous growth in a mammal, associated with pathological expression of a certain target genes identified herein. The compositions inhibit expression of the target gene when introduced into a tissue of the mammal. The methods include administering the compositions of the invention to a subject in need thereof in an amount effective to inhibit expression of a target gene in a cancerous tissue or organ.

摘要翻译： 用于治疗疾病如癌症的组合物和方法。 组合物通过刺激基因表达的RNA干扰的过程，从而抑制肿瘤生长，使沉默，下调或抑制有效靶基因的表达是有效的。 本发明还提供了通过使用中和抗体或小分子药物灭活经验证的靶基因产物来抑制肿瘤生长来治疗诸如癌症的疾病的方法。 更具体地，组合物和方法针对与本文鉴定的某些靶基因的病理表达相关的哺乳动物的癌症或癌前生长。 当引入哺乳动物的组织中时，组合物抑制靶基因的表达。 所述方法包括以有效抑制靶基因在癌组织或器官中的表达的量将本发明的组合物施用于有需要的受试者。

公开(公告)号：US20090227657A1

公开(公告)日：2009-09-10

申请号：US12420907

申请日：2009-04-09

申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

IPC分类号： A61K31/713 ,  C07H21/02 ,  C12N5/06

CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5146 ,  A61K31/70 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/32

摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

公开(公告)号：US07893243B2

公开(公告)日：2011-02-22

申请号：US11824084

申请日：2007-06-29

申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00

CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5146 ,  A61K31/70 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/32

摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

公开(公告)号：US07781414B2

公开(公告)日：2010-08-24

申请号：US10551667

申请日：2004-04-01

申请人： Patrick Y. Lu ,  Frank Y. Xie ,  Martin C. Woodle ,  Yijia Liu ,  Quinn Q. Tang ,  Jun Xu

发明人： Patrick Y. Lu ,  Frank Y. Xie ,  Martin C. Woodle ,  Yijia Liu ,  Quinn Q. Tang ,  Jun Xu

IPC分类号： A61K31/70 ,  C07H21/04 ,  C07H21/00 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/475 ,  C07K14/71 ,  C07K16/30 ,  C12N15/111 ,  C12N15/1135 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/12 ,  C12Q2600/112 ,  G01N33/57407 ,  G01N2500/00

摘要： The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.

摘要翻译： 本发明涉及通过分别通过上调，沉默和/或下调基因如EGFR-RP，TRA1，MFGE8，TNFSF13和ZFP236来操纵靶基因表达来治疗癌症的方法。 该方法可用于通过增强作为靶标的基因（例如ICT1030）的蛋白质，肽药物和基因治疗方式的表达来治疗癌症和/或抑制肿瘤生长; 或通过RNA干扰来沉默和/或下调诸如针对抗体，小分子和其他抑制剂药物形态验证的ICT1024，ICT1025和ICT1031和ICB1003的靶标。

公开(公告)号：US07723316B2

公开(公告)日：2010-05-25

申请号：US11824426

申请日：2007-06-29

申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

IPC分类号： A61K31/70 ,  C12Q1/68 ,  C07H21/04

CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5146 ,  A61K31/70 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/32

摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

公开(公告)号：US20090118208A1

公开(公告)日：2009-05-07

申请号：US11824084

申请日：2007-06-29

申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

IPC分类号： C07H21/02 ,  C07H21/00 ,  A61P9/00 ,  A61P35/00 ,  A61K31/7088

CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5146 ,  A61K31/70 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/32

摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。