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    INHIBITORY POLYNUCLEOTIDE COMPOSITIONS AND METHODS FOR TREATING CANCER
    2.
    发明申请
    INHIBITORY POLYNUCLEOTIDE COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
    抑制性多核苷酸组合物和治疗癌症的方法

    公开(公告)号：US20110038849A1

    公开(公告)日：2011-02-17

    申请号：US12519944

    申请日：2006-12-21

    申请人： Frank Y. Xie ,  Patrick Y. Lu ,  Martin C. Woodle ,  Yijia Liu

    发明人： Frank Y. Xie ,  Patrick Y. Lu ,  Martin C. Woodle ,  Yijia Liu

    IPC分类号： A61K39/395 ,  C07H21/04 ,  A61K31/7088 ,  C12N5/02 ,  C07K16/00 ,  A61P35/00

    CPC分类号： C12N15/1135 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2330/30

    摘要： Compositions and methods for treating diseases, such as cancers. The compositions are effective to silence, down-regulate or suppress the expression of a validated target gene by stimulating the process of RNA interference of gene expression, thus inhibiting tumor growth. The invention also provides methods for treating diseases, such as cancers, by inactivation of a validated target gene product, using neutralizing antibody or small molecule drug, to inhibit tumor growth. More particularly, the compositions and methods are directed toward a cancer or a precancerous growth in a mammal, associated with pathological expression of a certain target genes identified herein. The compositions inhibit expression of the target gene when introduced into a tissue of the mammal. The methods include administering the compositions of the invention to a subject in need thereof in an amount effective to inhibit expression of a target gene in a cancerous tissue or organ.

    摘要翻译： 用于治疗疾病如癌症的组合物和方法。 组合物通过刺激基因表达的RNA干扰的过程，从而抑制肿瘤生长，使沉默，下调或抑制有效靶基因的表达是有效的。 本发明还提供了通过使用中和抗体或小分子药物灭活经验证的靶基因产物来抑制肿瘤生长来治疗诸如癌症的疾病的方法。 更具体地，组合物和方法针对与本文鉴定的某些靶基因的病理表达相关的哺乳动物的癌症或癌前生长。 当引入哺乳动物的组织中时，组合物抑制靶基因的表达。 所述方法包括以有效抑制靶基因在癌组织或器官中的表达的量将本发明的组合物施用于有需要的受试者。

    COMPOSITION AND METHODS OF RNAi THERAPEUTICS FOR TREATMENT OF CANCER AND OTHER NEOVASCULARIZATION DISEASES
    5.
    发明申请
    COMPOSITION AND METHODS OF RNAi THERAPEUTICS FOR TREATMENT OF CANCER AND OTHER NEOVASCULARIZATION DISEASES 失效
    用于治疗癌症和其他新生血管疾病的RNAi治疗方法的组合物和方法

    公开(公告)号：US20090227657A1

    公开(公告)日：2009-09-10

    申请号：US12420907

    申请日：2009-04-09

    申请人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

    发明人： Yijia Liu ,  Patrick Y. Lu ,  Martin C. Woodle ,  Frank Y. Xie

    IPC分类号： A61K31/713 ,  C07H21/02 ,  C12N5/06

    CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5146 ,  A61K31/70 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/32

    摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.

    摘要翻译： 提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。 本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。 提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。 本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。 组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。