公开(公告)号：US20160377591A1

公开(公告)日：2016-12-29

申请号：US15217821

申请日：2016-07-22

Applicant: Quantum Biosystems Inc.

Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Floyd Oldham ,  Eric Scott Nordman

IPC: G01N33/487 ,  G01N27/447 ,  C12Q1/68

CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/4473 ,  G01N27/44791 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/631

Abstract: The present disclosure provides a biomolecule sequencing device that includes at least one set of nano-gap electrodes arranged so that a current flows when a biomolecule contained in a sample passes in proximity to the set of nano-gap electrodes, an electrophoresis electrode pair for forming an electric field for moving the biomolecule between the electrodes of the set of nano-gap electrodes, a flow path for flowing the sample in a direction towards the nano-gap electrode pair, a flow path for flowing the sample in a direction away from the nano-gap electrode pair, a measurement unit configured to measure a tunnel current generated when the biomolecule passes between the electrodes of the nano-gap electrode pair with an electric field being formed, and an identification unit configured to sequence the biomolecule.

Abstract translation: 本公开提供了一种生物分子测序装置，其包括至少一组纳米间隙电极组，所述至少一组纳米间隙电极被布置成当包含在样品中的生物分子通过一组纳米间隙电极时电流流动，用于形成的电泳对 用于在所述一组纳米间隙电极的电极之间移动所述生物分子的电场，用于使样品沿着朝向所述纳米间隙电极对的方向流动的流动路径，用于使样品沿远离所述纳米间隙电极对的方向流动的流动路径 纳米间隙电极对，测量单元，其被配置为测量当所述生物分子在所述纳米间隙电极对的电极之间通过所形成的电场时产生的隧道电流;以及识别单元，被配置为对所述生物分子进行排序。