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    DEVICES, SYSTEMS AND METHODS FOR SEQUENCING BIOMOLECULES
    2.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR SEQUENCING BIOMOLECULES 审中-公开
    用于测序生物分子的装置，系统和方法

    公开(公告)号：US20160377591A1

    公开(公告)日：2016-12-29

    申请号：US15217821

    申请日：2016-07-22

    Applicant: Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Floyd Oldham ,  Eric Scott Nordman

    IPC: G01N33/487 ,  G01N27/447 ,  C12Q1/68

    CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/4473 ,  G01N27/44791 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/631

    Abstract: The present disclosure provides a biomolecule sequencing device that includes at least one set of nano-gap electrodes arranged so that a current flows when a biomolecule contained in a sample passes in proximity to the set of nano-gap electrodes, an electrophoresis electrode pair for forming an electric field for moving the biomolecule between the electrodes of the set of nano-gap electrodes, a flow path for flowing the sample in a direction towards the nano-gap electrode pair, a flow path for flowing the sample in a direction away from the nano-gap electrode pair, a measurement unit configured to measure a tunnel current generated when the biomolecule passes between the electrodes of the nano-gap electrode pair with an electric field being formed, and an identification unit configured to sequence the biomolecule.

    Abstract translation: 本公开提供了一种生物分子测序装置，其包括至少一组纳米间隙电极组，所述至少一组纳米间隙电极被布置成当包含在样品中的生物分子通过一组纳米间隙电极时电流流动，用于形成的电泳对 用于在所述一组纳米间隙电极的电极之间移动所述生物分子的电场，用于使样品沿着朝向所述纳米间隙电极对的方向流动的流动路径，用于使样品沿远离所述纳米间隙电极对的方向流动的流动路径 纳米间隙电极对，测量单元，其被配置为测量当所述生物分子在所述纳米间隙电极对的电极之间通过所形成的电场时产生的隧道电流;以及识别单元，被配置为对所述生物分子进行排序。

    BIOMOLECULE SEQUENCING DEVICES, SYSTEMS AND METHODS
    4.
    发明申请
    BIOMOLECULE SEQUENCING DEVICES, SYSTEMS AND METHODS 审中-公开

    公开(公告)号：US20180023132A1

    公开(公告)日：2018-01-25

    申请号：US15448317

    申请日：2017-03-02

    Applicant: Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Oldham ,  Eric Nordman

    IPC: C12Q1/68 ,  G06F19/22 ,  G01N27/04

    Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.

    Method for controlling substance moving speed and apparatus for controlling the same
    6.
    发明授权
    Method for controlling substance moving speed and apparatus for controlling the same 有权
    控制物质移动速度的方法及其控制装置

    公开(公告)号：US09506894B2

    公开(公告)日：2016-11-29

    申请号：US13975610

    申请日：2013-08-26

    Applicant: Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Soh Ryuzaki ,  Masateru Taniguchi

    IPC: G01N27/447 ,  G01N33/487

    CPC classification number: G01N27/44756 ,  G01N27/44752 ,  G01N33/48721

    Abstract: The present invention provides a method and apparatus for controlling the moving speed of a substance, both of which can adjust the moving speed of a substance to a desired speed. The control method and control apparatus cause a substance to pass through an internal space, in which an electro-osmotic flow is generated, of a surround electrode formed so as to surround part of the moving path of the substance, whereby the control method and control apparatus change the moving speed of the substance.

    Abstract translation: 本发明提供了一种用于控制物质的移动速度的方法和装置，它们都可以将物质的移动速度调节到期望的速度。 控制方法和控制装置使物质通过形成为围绕物质的移动路径的一部分而形成的环境电极的产生电渗流的内部空间，由此控制方法和控制 设备改变物质的移动速度。

    BIOMOLECULE SEQUENCING DEVICES, SYSTEMS AND METHODS
    7.
    发明申请
    BIOMOLECULE SEQUENCING DEVICES, SYSTEMS AND METHODS 有权
    生物分子测序设备，系统和方法

    公开(公告)号：US20160319342A1

    公开(公告)日：2016-11-03

    申请号：US15061871

    申请日：2016-03-04

    Applicant: Osaka University ,  Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Oldham ,  Eric Nordman

    IPC: C12Q1/68 ,  G01N27/04 ,  G06F19/22

    CPC classification number: C12Q1/6869 ,  G01N27/04 ,  G01N33/48721 ,  G06F19/22 ,  C12Q2563/116 ,  C12Q2565/631

    Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.

    Abstract translation: 提供了用于测序蛋白质样品的设备，系统和方法。 在一些实例中，当在几个不同距离中的每一个测量单体通过纳米缝电极对的电极之间产生的电流，使得当与已知单体的参考物理量相比时，识别单体，其可以从 以类似的电极间距测量的电流，其中可以以预定精度识别和排序多种单体中的每一种，并且基于从隧道电流获得的检测到的物理量，其可以通过使用一个 或更多的参考物质。

    Biomolecule sequencing devices, systems and methods
    8.
    发明授权
    Biomolecule sequencing devices, systems and methods 有权

    公开(公告)号：US10557167B2

    公开(公告)日：2020-02-11

    申请号：US15448317

    申请日：2017-03-02

    Applicant: Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Oldham ,  Eric Nordman

    IPC: C12Q1/68 ,  G06F19/22 ,  G01N27/04 ,  C12Q1/6869 ,  G16B30/00

    Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.

    Sample analysis method
    9.
    发明授权
    Sample analysis method 有权
    样品分析方法

    公开(公告)号：US09535033B2

    公开(公告)日：2017-01-03

    申请号：US14421809

    申请日：2013-08-02

    Applicant: Quantum Biosystems Inc.

    Inventor： Tomoji Kawai ,  Takahito Ohshiro ,  Masateru Taniguchi

    IPC: G01N27/403 ,  G01N27/453 ,  G01N27/447 ,  G01N27/327 ,  G01N33/487 ,  G01N15/10

    CPC classification number: G01N27/447 ,  G01N15/1031 ,  G01N27/3275 ,  G01N27/4473 ,  G01N33/48721 ,  G01N2015/1006

    Abstract: The analysis method allows analysis of samples with high sensitivity, irrespective of interelectrode distance. The method includes: a step of applying a voltage between a first electrode pair such that an electric field is formed in a direction intersecting a migration direction of a sample; a step of placing a solution, including an electrochemically active molecule that produces a redox reaction at the electrode pair, between the first electrode pair; a step of causing the sample to migrate; and a step of measuring an amount of change in current flow between the first electrode pair.

    Abstract translation: 分析方法允许分析具有高灵敏度的样品，而不考虑电极间距离。 该方法包括：在与样品的迁移方向相交的方向形成电场的第一电极对之间施加电压的步骤; 在第一电极对之间放置包括在电极对产生氧化还原反应的电化学活性分子的溶液的步骤; 使样品迁移的步骤; 以及测量第一电极对之间的电流变化量的步骤。

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