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公开(公告)号：US20200209255A1
公开(公告)日：2020-07-02
申请号：US16709024
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20230058852A1
公开(公告)日：2023-02-23
申请号：US17690920
申请日：2022-03-09
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Mohammad Wadud Bhuiya , Manjula Pandey , Jeremy Lackey , Jonathan M. Rothberg , Thomas Christian
IPC: C12N9/12 , C12Q1/6869 , C12P19/34 , C12N15/52
Abstract: Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes. In some aspects, methods of using such polymerizing enzymes to synthesize a nucleic acid molecule or to sequence a nucleic acid template are provided.
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公开(公告)号：US20200209257A1
公开(公告)日：2020-07-02
申请号：US16709077
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20200209254A1
公开(公告)日：2020-07-02
申请号：US16708989
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
IPC: G01N33/68
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20200209249A1
公开(公告)日：2020-07-02
申请号：US16709103
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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Patent Agency Ranking
公开(公告)号：US20200219590A1
公开(公告)日：2020-07-09
申请号：US16686028
申请日：2019-11-15
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
IPC: G16B50/30 , G16B25/10 , G16B40/00 , C12Q1/6806
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20200209253A1
公开(公告)日：2020-07-02
申请号：US16708956
申请日：2019-12-10
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Jeremy Lackey , Thomas Christian , Roger Nani , David Dodd , Kathren Croce , Alexander Goryaynov , Jonathan M. Rothberg
Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20220128566A1
公开(公告)日：2022-04-28
申请号：US17511258
申请日：2021-10-26
Applicant: Quantum-Si Incorporated
Inventor： Thomas Christian , Kyle Preston , Brian Reed , Shannon Stewman
Abstract: Aspects of the present disclosure relate to techniques for calibrating an integrated device. According to some embodiments, there is provided a method for calibrating an integrated device, the method comprising: exciting, with light from at least one excitation source, a reference dye molecule; obtaining a signal emitted by the reference dye molecule, the signal containing information representative of at least one characteristic of the reference dye molecule; and adjusting one or more subsequent measurements obtained from a sample based on the information obtained from the signal emitted by the reference dye molecule.
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公开(公告)号：US11312944B2
公开(公告)日：2022-04-26
申请号：US15846967
申请日：2017-12-19
Applicant: Quantum-Si Incorporated
Inventor： Brian Reed , Mohammad Wadud Bhuiya , Manjula Pandey , Jeremy Lackey , Jonathan M. Rothberg , Thomas Christian
IPC: C12N9/12 , C12N15/52 , C12Q1/6869 , C12P19/34
Abstract: Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes. In some aspects, methods of using such polymerizing enzymes to synthesize a nucleic acid molecule or to sequence a nucleic acid template are provided.
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公开(公告)号：US10731209B2
公开(公告)日：2020-08-04
申请号：US15847001
申请日：2017-12-19
Applicant: Quantum-Si Incorporated
Inventor： James A. Ball , Jeremy Lackey , Brian Reed , Alexander Goryaynov , Jonathan M. Rothberg , Thomas Christian
IPC: C12Q1/6869 , C12Q1/6806 , B01L3/00 , B01L9/00 , C08L1/02 , C08L71/08
Abstract: Methods of loading a molecule of interest into a sample well are provided. In some aspects, methods of loading a molecule of interest into a sample well involve loading a molecule of interest into a sample well in the presence of a crowding agent and/or a condensing agent. In some aspects, methods of loading a sequencing template into a sample well are provided.
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