公开(公告)号：US20230134138A1

公开(公告)日：2023-05-04

申请号：US17977733

申请日：2022-10-31

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6827

Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.

公开(公告)号：US20200056240A1

公开(公告)日：2020-02-20

申请号：US16461356

申请日：2017-11-13

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6827

Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.

公开(公告)号：US11441188B2

公开(公告)日：2022-09-13

申请号：US15811515

申请日：2017-11-13

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12N15/10 ,  G01N33/487 ,  G01N33/49 ,  G01N33/53 ,  G01N33/533 ,  A61P43/00

Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., MITRA Tip). Kits for use in practicing the methods are also provided.

公开(公告)号：US20220033901A1

公开(公告)日：2022-02-03

申请号：US17397280

申请日：2021-08-09

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Hai-Rong Li ,  Feras Hantash ,  Frederic Waldman

IPC: C12Q1/6876 ,  C12Q1/6869

Abstract: Described herein are methods, compositions and kits directed to amplification of nucleic acids suitable for both next generation sequencing (NGS) and a second round of sequencing as validation, such as Sanger sequencing.

公开(公告)号：US20190284639A1

公开(公告)日：2019-09-19

申请号：US16349979

申请日：2017-11-13

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/6886 ,  C12Q1/6806

Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., MITRA Tip). Kits for use in practicing the methods are also provided.

公开(公告)号：US11486005B2

公开(公告)日：2022-11-01

申请号：US15811550

申请日：2017-11-13

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6827 ,  A61P43/00

Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.

公开(公告)号：US11441192B2

公开(公告)日：2022-09-13

申请号：US16349979

申请日：2017-11-13

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12N15/10 ,  G01N33/487 ,  G01N33/49 ,  G01N33/53 ,  G01N33/533 ,  A61P43/00

Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., MITRA Tip). Kits for use in practicing the methods are also provided.

公开(公告)号：US20180135135A1

公开(公告)日：2018-05-17

申请号：US15811515

申请日：2017-11-13

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/68 ,  G01N33/487 ,  C12N15/10 ,  G01N33/49 ,  G01N33/53 ,  G01N33/533

CPC classification number: C12Q1/6886 ,  C12N15/1058 ,  C12N15/1065 ,  C12Q1/6806 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N33/4875 ,  G01N33/49 ,  G01N33/5308 ,  G01N33/533 ,  C12Q2527/125

Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., MITRA Tip). Kits for use in practicing the methods are also provided.

公开(公告)号：US20180135128A1

公开(公告)日：2018-05-17

申请号：US15811550

申请日：2017-11-13

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2531/113 ,  C12Q2535/122

Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.

公开(公告)号：US20230078942A1

公开(公告)日：2023-03-16

申请号：US17942927

申请日：2022-09-12

Applicant: Quest Diagnostics Investments LLC

Inventor： Heather Sanders ,  Nigel J. Clarke

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12N15/10 ,  G01N33/487 ,  G01N33/49 ,  G01N33/53 ,  G01N33/533

Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., MITRA Tip). Kits for use in practicing the methods are also provided.