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公开(公告)号：US20200231553A1
公开(公告)日：2020-07-23
申请号：US16748440
申请日：2020-01-21
IPC分类号： C07D241/44 , A61K9/14 , A61K45/06 , A61K31/498
摘要： The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US10052321B2
公开(公告)日：2018-08-21
申请号：US15660468
申请日：2017-07-26
发明人： Young Bok Lee , Chang-Ho Ahn , Deog Joong Kim
IPC分类号： A61K9/14 , A61K31/498 , A61K9/51
摘要： The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer are also described.
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公开(公告)号：US20180290985A1
公开(公告)日：2018-10-11
申请号：US15946955
申请日：2018-04-06
IPC分类号： C07D241/44 , A61K45/06 , A61K9/14 , A61K31/498 , A61K9/08 , A61K47/02
CPC分类号： C07D241/44 , A61K9/08 , A61K9/14 , A61K31/498 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20180021338A1
公开(公告)日：2018-01-25
申请号：US15683408
申请日：2017-08-22
IPC分类号： A61K31/513 , C07D239/47 , A61K45/06 , A61K9/48
CPC分类号： A61K31/513 , A61K9/0053 , A61K9/20 , A61K9/2004 , A61K9/48 , A61K9/4841 , A61K39/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07D239/47 , C07K16/2818 , C07K16/2827 , C07K2317/76 , C12Y207/01048 , G01N33/57496 , G01N2333/91215 , G01N2800/52 , A61K2300/00
摘要： The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (I) and a process for preparing such.
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公开(公告)号：US20180008601A1
公开(公告)日：2018-01-11
申请号：US15660468
申请日：2017-07-26
发明人： Young Bok Lee , Chang-Ho Ahn , Deog Joong Kim
IPC分类号： A61K31/498 , A61K9/14 , A61K9/51
摘要： The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer are also described.
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公开(公告)号：US09713615B2
公开(公告)日：2017-07-25
申请号：US14919450
申请日：2015-10-21
发明人： Young Bok Lee , Jae Min Kim , Deog Joong Kim , Chang-Ho Ahn
IPC分类号： A61K31/517 , C07D401/06 , C07D417/14 , C07D401/14 , A61K47/48
CPC分类号： A61K31/517 , A61K47/66 , C07D401/06 , C07D401/14 , C07D417/14
摘要： Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.
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公开(公告)号：US20190275042A1
公开(公告)日：2019-09-12
申请号：US16356328
申请日：2019-03-18
IPC分类号： A61K31/513 , A61K39/00 , C07D239/47 , A61K9/48 , A61K9/20 , A61K9/00 , G01N33/574 , A61K39/395 , A61K45/06 , C07K16/28
摘要： The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a hydrate, a solvate, or a pharmaceutically acceptable salt thereof. The disclosed subject matter further provides a method of treating one or more symptoms of cancer comprising administering to a subject in need thereof a compound of formula (I) and a process for preparing such.
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公开(公告)号：US09920016B2
公开(公告)日：2018-03-20
申请号：US15379553
申请日：2016-12-15
发明人： Deog Joong Kim , Haifeng Yin , Eliezer Falb , Leigh Andre Pearcey , Jonathan Cummins , Petra Dieterich , Jean-Francois Carniaux , Yi Wang , Vikram Chandrakant Purohit
IPC分类号： C07D239/47 , C07F7/18 , C07D317/44 , C07D405/04 , C07D317/22
CPC分类号： C07D239/47 , C07D317/22 , C07D317/44 , C07D405/04 , C07F7/1892
摘要： Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3 -hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one(13, RX-3117) and its intermediates are described.
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9.发明申请公开(公告)号：US20160136166A1
公开(公告)日：2016-05-19
申请号：US14919450
申请日：2015-10-21
发明人： Young Bok Lee , Jae Min Kim , Deog Joong Kim , Chang-Ho Ahn
IPC分类号： A61K31/517 , A61K47/48
CPC分类号： A61K31/517 , A61K47/66 , C07D401/06 , C07D401/14 , C07D417/14
摘要： Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.
摘要翻译： 描述了由式（I）表示的四氢异喹啉-2-基 - （喹唑啉-4-基）甲酮衍生物，其药理学上可接受的盐，以及含有这些化合物的组合物。 还描述了通过施用化合物治疗过度增殖性疾病的方法。 还描述了用于制备四氢异喹啉-2-基 - （喹唑啉-4-基）甲酮化合物的1,2,3,4-四氢异喹啉衍生物。
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10.发明申请Process for the Preparation of 4-Amino-1-((1S,4R,5S)-2-Fluoro-4,5-Dihydroxy-3-Hydroxymethyl-Cyclopent-2-Enyl)-1H-Pyrimidin-2-One 有权制备4-氨基-1 - （（1S，4R，5S）-2-氟-4,5-二羟基-3-羟甲基 - 环戊-2-烯基）-1H-嘧啶-2-酮的方法公开(公告)号：US20150376142A1
公开(公告)日：2015-12-31
申请号：US14845968
申请日：2015-09-04
发明人： Haifeng Yin , Deog Joong Kim , Eliezer Falb , Leigh Andre Pearcey , Jonathan Cummins , Petra Dieterich , Jean-Francois Carniaux , Yi Wang , Vikram Chandrakant Purohit
IPC分类号： C07D239/47 , C07D317/44 , C07D405/04 , C07F7/18
CPC分类号： C07D239/47 , C07D317/22 , C07D317/44 , C07D405/04 , C07F7/1892
摘要： Processes for the preparation of 4-amino-1((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one (13, RX-3117) and its intermediates are described.
摘要翻译： 制备4-氨基-1（（1S，4R，5S）-2-氟-4,5-二羟基-3-羟甲基 - 环戊-2-烯基）-1H-嘧啶-2-酮的方法（13， RX-3117）及其中间体。
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