公开(公告)号：US20200332289A1

公开(公告)日：2020-10-22

申请号：US15733306

申请日：2018-12-21

申请人： Roche Innovation Center Copenhagen A/S

发明人： Konrad BLEICHER ,  Joerg DUSCHMALÉ ,  Martina Brigitte DUSCHMALÉ ,  Henrik Frydenlund HANSEN ,  Erik FUNDER ,  Troels KOCH ,  Meiling LI ,  Adrian SCHAEUBLIN ,  Xi SHU ,  Yong WU

IPC分类号： C12N15/113

摘要： The present invention relates to a gapmer oligonucleotide comprising at phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicament.

公开(公告)号：US20200339982A1

公开(公告)日：2020-10-29

申请号：US15733307

申请日：2018-12-21

申请人： Roche Innovation Center Copenhagen A/S

发明人： Konrad BLEICHER ,  Henrik Frydenlund HANSEN ,  Troels KOCH ,  Jesper WORM ,  Adrian SCHAEUBLIN ,  Erik FUNDER ,  Joerg DUSCHMALÉ ,  Lars JOENSON ,  Meiling LI ,  Martina Brigitte DUSCHMALÉ ,  Yong WU ,  Xi SHU

IPC分类号： C12N15/11 ,  C07H21/00 ,  C07H1/00

摘要： The present invention relates to an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I) (I) as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament.

公开(公告)号：US20230002762A1

公开(公告)日：2023-01-05

申请号：US17720676

申请日：2022-04-14

申请人： ROCHE INNOVATION CENTER COPENHAGEN A/S

发明人： Konrad Bleicher ,  Henrik Frydenlund HANSEN ,  Troels KOCH ,  Jesper WORM ,  Adrian SCHAEUBLIN ,  Erik FUNDER ,  Joerg DUSCHMALÉ ,  Lars JOENSON ,  Meiling LI ,  Martina Brigitte DUSCHMALÉ ,  Yong WU ,  Xi SHU

IPC分类号： C12N15/11 ,  C07H1/00 ,  C07H21/00

摘要： The present invention relates to an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I) (I) as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicement.