专利检索 ap:("ROCHE INNOVATION CENTER COPENHAGEN A/S") AND inv:"Martina Brigitte DUSCHMALÉ" 第 1 页

1.

发明申请
OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE 审中-公开

公开(公告)号：US20200339982A1

公开(公告)日：2020-10-29

申请号：US15733307

申请日：2018-12-21

申请人： Roche Innovation Center Copenhagen A/S

发明人： Konrad BLEICHER , Henrik Frydenlund HANSEN , Troels KOCH , Jesper WORM , Adrian SCHAEUBLIN , Erik FUNDER , Joerg DUSCHMALÉ , Lars JOENSON , Meiling LI , Martina Brigitte DUSCHMALÉ , Yong WU , Xi SHU

IPC分类号： C12N15/11 , C07H21/00 , C07H1/00

摘要： The present invention relates to an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I) (I) as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament.

2.

发明申请
OLIGONUCLEOTIDES COMPRISING A PHOSPHOROTRITHIOATE INTERNUCLEOSIDE LINKAGE 有权

公开(公告)号：US20210221837A1

公开(公告)日：2021-07-22

申请号：US17055510

申请日：2019-07-29

申请人： Roche Innovation Center Copenhagen A/S

发明人： Konrad BLEICHER , Joerg Jakob Andreas DUSCHMALÉ , Martina Brigitte DUSCHMALÉ , Troels KOCH , Erich KOLLER , Meiling LI , Adrian SCHAEUBLIN

IPC分类号： C07H21/04 , C07H1/04 , C07H21/02 , A61K31/7105 , A61K31/711

摘要： The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I) as defined herein. The oligonucleotide of the invention can be used as a medicament.

3.

发明申请
GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE 审中-公开

公开(公告)号：US20200332289A1

公开(公告)日：2020-10-22

申请号：US15733306

申请日：2018-12-21

申请人： Roche Innovation Center Copenhagen A/S

发明人： Konrad BLEICHER , Joerg DUSCHMALÉ , Martina Brigitte DUSCHMALÉ , Henrik Frydenlund HANSEN , Erik FUNDER , Troels KOCH , Meiling LI , Adrian SCHAEUBLIN , Xi SHU , Yong WU

IPC分类号： C12N15/113

摘要： The present invention relates to a gapmer oligonucleotide comprising at phosphorodithioate internucleoside linkage of formula (I) as defined in the description and in the claims. The oligonucleotide of the invention can be used as a medicament.

4.

发明申请
OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE 有权

公开(公告)号：US20230002762A1

公开(公告)日：2023-01-05

申请号：US17720676

申请日：2022-04-14

申请人： ROCHE INNOVATION CENTER COPENHAGEN A/S

发明人： Konrad Bleicher , Henrik Frydenlund HANSEN , Troels KOCH , Jesper WORM , Adrian SCHAEUBLIN , Erik FUNDER , Joerg DUSCHMALÉ , Lars JOENSON , Meiling LI , Martina Brigitte DUSCHMALÉ , Yong WU , Xi SHU

IPC分类号： C12N15/11 , C07H1/00 , C07H21/00

摘要： The present invention relates to an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I) (I) as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicement.

5.

发明申请
NOVEL THIOPHOSPHORAMIDITES 有权

公开(公告)号：US20210115438A1

公开(公告)日：2021-04-22

申请号：US15733302

申请日：2018-12-21

申请人： ROCHE INNOVATION CENTER COPENHAGEN A/S

发明人： Konrad BLEICHER , Joerg DUSCHMALÉ , Martina Brigitte DUSCHMALÉ , Henrik Frydenlund HANSEN , Troels KOCH , Meiling LI , Adrian SCHAEUBLIN , Xi SHU , Yong WU

IPC分类号： C12N15/113 , C07H19/10 , C07H19/20 , C07H21/04 , C07H1/00

摘要： The present invention relates to a compound of formula (II) or (IIb) Wherein X, Y, Rx, Ry, R5 and Nu are as defined in the description and in the claims. The compound of formula (II) can be used in the manufacture of oligonucleotides.