公开(公告)号：US11166938B2

公开(公告)日：2021-11-09

申请号：US16313876

申请日：2017-06-28

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Masatoshi Haga ,  Yuya Hayashi

IPC: A61K31/375 ,  A61K8/86 ,  A61P17/10 ,  A61P17/18 ,  A61K31/357 ,  A61P17/00 ,  A61K47/22 ,  A61K8/34 ,  A61K8/41 ,  A61K8/55 ,  A61K8/67 ,  A61K9/00 ,  A61K47/18 ,  A61K47/24 ,  A61Q19/02 ,  A61Q19/08 ,  A61K47/10

Abstract: Provided is an external composition excellent in stability and impression from use. An external composition containing (A) at least one member selected from the group consisting of ascorbic acid and salts of ascorbic acid, (B) at least one member selected from the group consisting of 3-O-ethylascorbic acid, salts of 3-O-ethylascorbic acid, and hydroxylated lecithin, and (C) polyethylene glycol is prepared.

公开(公告)号：US20170209522A1

公开(公告)日：2017-07-27

申请号：US15322779

申请日：2015-06-30

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Masatoshi Haga ,  Keiko Oyamada ,  Rumi Matsushita ,  Yuya Hayashi ,  Kyoko Nakajima ,  Yuko Kouda

IPC: A61K38/05 ,  A61K8/67 ,  A61K8/34 ,  A61Q19/08 ,  A61K47/10 ,  A61Q11/00 ,  A61K31/045 ,  A61K31/375 ,  A61K9/00 ,  A61K45/06 ,  A61K8/64 ,  A61Q15/00

CPC classification number: A61K38/05 ,  A61K8/34 ,  A61K8/44 ,  A61K8/4946 ,  A61K8/64 ,  A61K8/676 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/12 ,  A61K31/122 ,  A61K31/375 ,  A61K31/506 ,  A61K31/7034 ,  A61K45/06 ,  A61K47/10 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/08 ,  A61K2300/00

Abstract: An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging.The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

公开(公告)号：US12263239B2

公开(公告)日：2025-04-01

申请号：US16958389

申请日：2018-12-27

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yu Kitaoka ,  Masatoshi Haga

IPC: A61K8/67 ,  A61K8/34 ,  A61K8/41 ,  A61Q19/02 ,  A61Q19/08

Abstract: The present invention provides an external composition superior in stability and use feeling. According to the present invention, an external composition is prepared which includes (A) at least one selected from the group consisting of an ascorbic acid and an ascorbic salt, (B) a diol having 3 carbon atoms, (C) at least one selected from the group consisting of a low-molecular-weight betaine, an organic acid salt, an inorganic acid salt, a basic amino acid, a basic amino acid salt, 3-O-ethylascorbic acid, and a 3-O-ethylascorbic acid salt, and (D) water, and a content of ethoxydiglycol of said composition is less than 30 mass %.