公开(公告)号：US20230172969A1

公开(公告)日：2023-06-08

申请号：US17921065

申请日：2021-03-31

Applicant: Rohto Pharmaceutical Co., Ltd.

Inventor： Tatsuya Ando ,  Yoko Mitsuguchi ,  Sachiko Matsumoto ,  Atsuko Nakata

IPC: A61K31/737 ,  A61K9/00 ,  A61K31/23 ,  A61K31/355 ,  A61K31/205 ,  A61K31/198 ,  A61K31/27 ,  A61K47/38 ,  A61K31/4415 ,  A61K31/16 ,  A61P27/04 ,  A61K31/4166 ,  A61K31/704

CPC classification number: A61K31/737 ,  A61K9/0048 ,  A61K31/23 ,  A61K31/355 ,  A61K31/205 ,  A61K31/198 ,  A61K31/27 ,  A61K47/38 ,  A61K31/4415 ,  A61K31/16 ,  A61P27/04 ,  A61K31/4166 ,  A61K31/704

Abstract: The present invention relates to an ophthalmic composition for suppressing eye dryness, comprising at least one selected from the group consisting of chondroitin sulfate having a weight average molecular weight of 30,000 to 50,000 and a salt thereof.

公开(公告)号：US20150018416A1

公开(公告)日：2015-01-15

申请号：US14384810

申请日：2013-11-29

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Ryo Komurasaki ,  Yoko Mizutare ,  Atsuko Nakata

IPC: A61K47/44 ,  A61K47/10 ,  A61K31/07 ,  A01N25/22 ,  A61K31/23 ,  A01N37/36

CPC classification number: A61K47/44 ,  A01N25/22 ,  A01N37/36 ,  A61K9/0048 ,  A61K31/07 ,  A61K31/23 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: The present invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil, (B) polyethylene glycol monostearate, and (C) at least one member selected from the group consisting of sesame oil, castor oil, vitamin A, and chlorobutanol.

Abstract translation: 本发明涉及包含（A）聚氧乙烯蓖麻油，（B）聚乙二醇单硬脂酸酯和（C）至少一种选自由芝麻油，蓖麻油，维生素A和氯丁醇组成的组的组合物的水性眼用组合物。

公开(公告)号：US20180289812A1

公开(公告)日：2018-10-11

申请号：US15766514

申请日：2016-11-22

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Aki Kiyomiya ,  Takahiro Kurose ,  Atsuko Nakata ,  Xiang Zheng

IPC: A61K47/32 ,  A61K47/34 ,  A61K47/44 ,  G02C7/04

Abstract: The inventive ophthalmic composition comprises: (A) polyvinyl pyrrolidone K90; and (B) at least one selected from the group consisting of an oil component, a grease component and polyethylene glycol. The ophthalmic composition alleviates a sticky sensation to ensure an excellent use sensation.

公开(公告)号：US09427473B2

公开(公告)日：2016-08-30

申请号：US14384810

申请日：2013-11-29

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Ryo Komurasaki ,  Yoko Mizutare ,  Atsuko Nakata

IPC: A61K31/07 ,  A61K31/23 ,  A61K47/44 ,  A61K47/10 ,  A61K47/14 ,  A61K9/00 ,  A01N25/22 ,  A01N37/36

CPC classification number: A61K47/44 ,  A01N25/22 ,  A01N37/36 ,  A61K9/0048 ,  A61K31/07 ,  A61K31/23 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: The present invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil, (B) polyethylene glycol monostearate, and (C) at least one member selected from the group consisting of sesame oil, castor oil, vitamin A, and chlorobutanol.

Abstract translation: 本发明涉及包含（A）聚氧乙烯蓖麻油，（B）聚乙二醇单硬脂酸酯和（C）至少一种选自由芝麻油，蓖麻油，维生素A和氯丁醇组成的组的组合物的水性眼用组合物。

公开(公告)号：US20160243030A1

公开(公告)日：2016-08-25

申请号：US15147415

申请日：2016-05-05

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Ryo Komurasaki ,  Yoko Mizutare ,  Atsuko Nakata

IPC: A61K9/00 ,  A61K47/44 ,  A61K47/34 ,  A61K31/07

CPC classification number: A61K47/44 ,  A01N25/22 ,  A01N37/36 ,  A61K9/0048 ,  A61K31/07 ,  A61K31/23 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: The present invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil, (B) polyethylene glycol monostearate, and (C) at least one member selected from the group consisting of sesame oil, castor oil, vitamin A, and chlorobutanol.

公开(公告)号：US09345779B2

公开(公告)日：2016-05-24

申请号：US14634270

申请日：2015-02-27

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Atsuko Nakata ,  Eri Matsumoto

IPC: A61K47/46 ,  A61K47/44 ,  A61K9/00 ,  A61K47/02

CPC classification number: A61K47/46 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/44

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil. According to the aqueous ophthalmic composition of the present invention, defoaming time is reduced, preservative efficacy is enhanced and photostability is improved.

公开(公告)号：US09050369B2

公开(公告)日：2015-06-09

申请号：US13720734

申请日：2012-12-19

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Atsuko Nakata ,  Eri Matsumoto

IPC: A61K47/44 ,  A61K9/00

CPC classification number: A61K47/46 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/44

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil. According to the aqueous ophthalmic composition of the present invention, defoaming time is reduced, preservative efficacy is enhanced and photostability is improved.

Abstract translation: 本发明涉及含有（A）聚氧乙烯蓖麻油和（B）芝麻油的水性眼用组合物。 根据本发明的水性眼用组合物，消泡时间降低，防腐效果提高，光稳定性提高。

公开(公告)号：US09320802B2

公开(公告)日：2016-04-26

申请号：US14683579

申请日：2015-04-10

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Chinatsu Furumiya ,  Takayuki Miyano ,  Atsuko Nakata ,  Eri Matsumoto

IPC: A61K47/10 ,  A61K47/44 ,  A61K9/08 ,  A61K9/00 ,  A61K47/02 ,  A61K47/26 ,  A61K47/24

CPC classification number: A61K47/44 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the average number of moles of added ethylene oxide is 2 to 12 and (B) terpenoid. According to the present invention, an aqueous ophthalmic composition having an improved foam disappearance speed can be obtained.