公开(公告)号：US20140296348A1

公开(公告)日：2014-10-02

申请号：US14355383

申请日：2012-10-31

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko Matsumura ,  Chinatsu Furumiya ,  Masashi Itoh

IPC: A61K47/02 ,  A61K31/045

CPC classification number: A61K47/02 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K2300/00

Abstract: The present invention provides an aqueous ophthalmic composition having a pH of 7 or more, containing a terpenoid and zinc chloride. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.

Abstract translation: 本发明提供了含有萜类化合物和氯化锌的pH为7以上的水性眼用组合物。 根据本发明，提供一种眼科组合物，其中可以抑制萜类化合物对容器的吸附，从而可以长时间抑制萜类化合物含量的降低，眼用组合物具有一些 优良的作用如对组胺释放的抑制作用，以及从眼睛排出的抑制作用。

公开(公告)号：US09173945B2

公开(公告)日：2015-11-03

申请号：US14355350

申请日：2012-10-31

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko Matsumura ,  Chinatsu Furumiya ,  Masashi Itoh

IPC: A61F2/00 ,  A61K47/38 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K9/00 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36

CPC classification number: A61K47/38 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K2300/00

Abstract: The present invention provides an aqueous ophthalmic composition containing (A) a terpenoid, (B) zinc chloride, and (C) at least one member selected from the group consisting of cellulose-based polymeric compounds, vinyl-based polymeric compounds, polyethylene glycols and dextran. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.

Abstract translation: 本发明提供含有（A）萜类化合物，（B）氯化锌和（C）至少一种选自纤维素基聚合物，乙烯基类聚合物，聚乙二醇和 葡聚糖 根据本发明，提供一种眼科组合物，其中可以抑制萜类化合物对容器的吸附，从而可以长时间抑制萜类化合物含量的降低，眼用组合物具有一些 优良的作用如对组胺释放的抑制作用，以及从眼睛排出的抑制作用。

公开(公告)号：US20140308368A1

公开(公告)日：2014-10-16

申请号：US14355350

申请日：2012-10-31

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko Matsumura ,  Chinatsu Furumiya ,  Masashi Itoh

IPC: A61K47/38 ,  A61K31/122 ,  A61K47/36 ,  A61K33/30 ,  A61K47/32 ,  A61K47/10 ,  A61K31/045 ,  A61K31/125

CPC classification number: A61K47/38 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K2300/00

Abstract: The present invention provides an aqueous ophthalmic composition containing (A) a terpenoid, (B) zinc chloride, and (C) at least one member selected from the group consisting of cellulose-based polymeric compounds, vinyl-based polymeric compounds, polyethylene glycols and dextran. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.

Abstract translation: 本发明提供含有（A）萜类化合物，（B）氯化锌和（C）至少一种选自纤维素基聚合物，乙烯基类聚合物，聚乙二醇和 葡聚糖 根据本发明，提供一种眼科组合物，其中可以抑制萜类化合物对容器的吸附，从而可以长时间抑制萜类化合物含量的降低，眼用组合物具有一些 优良的作用如对组胺释放的抑制作用，以及从眼睛排出的抑制作用。

公开(公告)号：US09320802B2

公开(公告)日：2016-04-26

申请号：US14683579

申请日：2015-04-10

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Chinatsu Furumiya ,  Takayuki Miyano ,  Atsuko Nakata ,  Eri Matsumoto

IPC: A61K47/10 ,  A61K47/44 ,  A61K9/08 ,  A61K9/00 ,  A61K47/02 ,  A61K47/26 ,  A61K47/24

CPC classification number: A61K47/44 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the average number of moles of added ethylene oxide is 2 to 12 and (B) terpenoid. According to the present invention, an aqueous ophthalmic composition having an improved foam disappearance speed can be obtained.