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公开(公告)号：US20160145628A1
公开(公告)日：2016-05-26
申请号：US14899183
申请日：2014-06-18
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , ROSETTA GENOMICS LTD.
Inventor： Noga Yerushalmi , Sharon Kredo-Russo , Gila Lithwick Yanai , Ronit Satchi-Fainaro , Paula Ofek
IPC: C12N15/113 , A61K31/713 , A61K47/48
CPC classification number: C12N15/1138 , A61K31/713 , A61K47/60 , C12N2310/141 , C12N2310/351
Abstract: Described herein are novel polyglycerol-amine polymeric nanocarriers in complex with microRNAs and their uses in the treatment of cancer, in particular glioblastoma. Delivery of the polymeric nanocarriers in complex with microRNAs in cell lines and in vivo inhibited cell proliferation, cell cycle progression, cell migration and tumor growth.
Abstract translation: 本文描述的是与微小RNA复合的新型聚甘油 - 胺聚合纳米载体及其在治疗癌症中的用途，特别是成胶质细胞瘤。 在细胞系和体内与微小RNA复合的聚合纳米载体的递送抑制细胞增殖，细胞周期进程，细胞迁移和肿瘤生长。
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公开(公告)号：US20190112665A1
公开(公告)日：2019-04-18
申请号：US15975533
申请日：2018-05-09
Applicant: ROSETTA GENOMICS LTD. , MOR RESEARCH APPLICATIONS
Inventor： Moshe Hoshen , Gila Lithwick Yanai , Ram Eitan
IPC: C12Q1/6886 , A61K31/713 , A61K45/00
Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention further provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions for the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.
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公开(公告)号：US20170016076A1
公开(公告)日：2017-01-19
申请号：US15237364
申请日：2016-08-15
Applicant: ROSETTA GENOMICS, LTD.
Inventor： Zohar Barnett-Itzhaki , Gila Lithwick Yanai , Eti Meiri , Yael Spector , Hila Benjamin , Nir Dromi
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/18 , G06F19/20
Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
Abstract translation: 本发明提供了通过分析细针抽吸样品中特异性微小RNA的表达模式来分类甲状腺肿瘤的方法。 根据微小RNA表达特征的甲状腺肿瘤分类可以优化诊断和治疗，以及确定特异性特异性治疗。
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公开(公告)号：US09708667B2
公开(公告)日：2017-07-18
申请号：US15237364
申请日：2016-08-15
Applicant: ROSETTA GENOMICS, LTD.
Inventor： Gila Lithwick Yanai , Eti Meiri , Yael Spector , Hila Benjamin , Nir Dromi
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/18 , G06F19/20
Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
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Patent Agency Ranking
公开(公告)号：US20170073775A1
公开(公告)日：2017-03-16
申请号：US15363822
申请日：2016-11-29
Applicant: ROSETTA GENOMICS LTD. , MOR RESEARCH APPLICATIONS
Inventor： Moshe Hosen , Gila Lithwick Yanai , Ram Eitan
IPC: C12Q1/68 , A61K45/00 , A61K31/713
CPC classification number: C12Q1/6886 , A61K31/713 , A61K45/00 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/16 , C12Q2600/178
Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention farther provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions liar the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.
Abstract translation: 本文描述了用于预测卵巢癌患者预后的组合物和方法。 本发明还提供了区分卵巢癌肿瘤的组织学亚型的方法，还涉及治疗或预防卵巢癌的方法和组合物。 具体地说，本发明涉及与所述方法和组合物相关的微小RNA分子，以及与之有关的或从其衍生的各种核酸分子。
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公开(公告)号：US20190300963A1
公开(公告)日：2019-10-03
申请号：US16192221
申请日：2018-11-15
Applicant: ROSETTA GENOMICS LTD.
Inventor： Zohar Barnett-Itzhaki , Gila Lithwick Yanai , Eti Meiri , Yael Spector , Hila Benjamin , Nir Dromi
IPC: C12Q1/6886 , G16B20/00 , G16B25/00
Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
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公开(公告)号：US09988690B2
公开(公告)日：2018-06-05
申请号：US15363822
申请日：2016-11-29
Applicant: ROSETTA GENOMICS LTD. , MOR RESEARCH APPLICATIONS
Inventor： Moshe Hoshen , Gila Lithwick Yanai , Ram Eitan
IPC: C12Q1/68 , A61K31/713 , A61K45/00
CPC classification number: C12Q1/6886 , A61K31/713 , A61K45/00 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/16 , C12Q2600/178
Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention further provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions for the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.
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公开(公告)号：US20170356055A1
公开(公告)日：2017-12-14
申请号：US15625645
申请日：2017-06-16
Applicant: ROSETTA GENOMICS, LTD.
Inventor： Zohar Barnett-Itzhaki , Gila Lithwick Yanai , Eti Meiri , Yael Spector , Hila Benjamin , Nir Dromi
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G16B20/00 , G16B25/00
Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
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公开(公告)号：US20150099665A1
公开(公告)日：2015-04-09
申请号：US14572276
申请日：2014-12-16
Inventor： Nitzan Rosenfeld , Shai Rosenwald , Iris Barshack , Gila Lithwick Yanai
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y10T436/143333
Abstract: The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of lung cancers. The present invention further provides microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom, associated with specific types of lung cancers.
Abstract translation: 本发明提供了用于肺癌鉴定，分类和诊断的核酸序列。 本发明进一步提供与特定类型的肺癌相关的微小RNA分子，以及与之相关的或由其衍生的各种核酸分子。
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