公开(公告)号：US3850959A

公开(公告)日：1974-11-26

申请号：US39670373

申请日：1973-09-13

Applicant: ROUSSEL UCLAF

Inventor： DUBE J ,  ALLAIS A ,  MEIER J

IPC: C07D309/06 ,  C07D65/04 ,  A61K27/00

CPC classification number: C07D309/06

Abstract: 1. A COMPOUND OF THE FORMULA

X
(CH2)2-)

WHEREIN HAL IS HALOGEN, X IS SELECTED FROM THE GROUP CONSISTING OF OXYGEN AND SULFUR AND R IS ALKYL OF 1 TO 4 CARBON ATOMS.

公开(公告)号：US3741988A

公开(公告)日：1973-06-26

申请号：US3741988D

申请日：1971-04-12

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS A ,  MEIER J ,  DUBE J

IPC: C07C69/738 ,  A61K31/215 ,  A61K31/25 ,  A61K31/335 ,  A61K31/357 ,  A61P25/04 ,  A61P29/00 ,  C07C49/813 ,  C07C51/08 ,  C07C59/88 ,  C07C65/36 ,  C07C67/00 ,  C07C245/14 ,  C07C313/00 ,  C07C323/62 ,  C07D317/24 ,  C07F3/00 ,  C07D13/04

CPC classification number: C07F3/00 ,  C07C49/813 ,  C07C51/08 ,  C07C59/88 ,  C07C65/36 ,  C07C245/14 ,  C07D317/24

Abstract: Racemates and optically active isomers of benzoylphenylacetic acid esters of the formula

WHEREIN R is selected from the group consisting of hydrogen and alkyl of one to seven carbon atoms, R1 and R2 are hydrogen or taken together are

P and Q being alkyl of one to five carbon atoms and the two benzene rings may be optionally substituted with at least one member of the group consisting of chlorine, fluorine, bromine, trifluoromethyl and alkyl and alkoxy and alkylthio of one to seven carbon atoms, intermediates and process for their preparation and their use as analgesics and antiinflammatory agents.

Abstract translation: 式WHEREIN R的苯甲酰基苯基乙酸酯的外消旋物和旋光异构体选自氢和1至7个碳原子的烷基，R 1和R 2是氢或一起是P和Q是一至五个碳的烷基 原子，两个苯环可以任选被至少一个由氯，氟，溴，三氟甲基组成的组中的一个或多个碳原子的烷基和烷氧基和烷硫基取代，中间体及其制备方法及其用途如 镇痛药和抗炎药。

公开(公告)号：US3829585A

公开(公告)日：1974-08-13

申请号：US34677073

申请日：1973-04-02

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS A ,  MEIER J ,  DUBE J

IPC: C07C69/738 ,  A61K31/215 ,  A61K31/25 ,  A61K31/335 ,  A61K31/357 ,  A61P25/04 ,  A61P29/00 ,  C07C49/813 ,  C07C51/08 ,  C07C59/88 ,  C07C65/36 ,  C07C67/00 ,  C07C245/14 ,  C07C313/00 ,  C07C323/62 ,  C07D317/24 ,  C07F3/00 ,  A61K27/00

CPC classification number: C07F3/00 ,  C07C49/813 ,  C07C51/08 ,  C07C59/88 ,  C07C65/36 ,  C07C245/14 ,  C07D317/24

Abstract: P and Q being alkyl of 1 to 5 carbon atoms and the two benzene rings may be optionally substituted with at least one member of the group consisting of chlorine, fluorine, bromine, trifluoromethyl and alkyl and alkoxy and alkylthio of 1 to 7 carbon atoms, intermediates and process for their preparation and their use as analgesics and antiinflammatory agents.

WHEREIN R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, R1 and R2 are hydrogen or taken together are

Racemates and optically active isomers of benzoylphenyl-acetic acid esters of the formula

公开(公告)号：US3772332A

公开(公告)日：1973-11-13

申请号：US3772332D

申请日：1972-04-12

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS A ,  MEIER J ,  DUBE J

IPC: C07D335/02 ,  C07D309/02 ,  C07D309/04 ,  C07D309/06 ,  A61K27/00 ,  C07D65/04

CPC classification number: C07D309/06 ,  C07D309/04

Abstract: NOVEL COMPOUNDS OF THE FORMULA

(2-HAL,4-(R-OOC-Z-)PHENYL)-CH
WHEREIN X IS SELECTED FROM THE GROUP CONSISTING OF OXYGEN, SULFUR, SO AND SO2, R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ANION OF A NON-TOXIC; THERAPEUTICALLY ACCEPTABLE ORGANIC OR MINERAL BASE AND RESIDUE OF AN ALCOHOL, AN Z IS SELCETED FROM THE GROUP CONSISTING OF -CHR1- AND >C=R2 WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND STRAINGT OR BRANCHED ALKYL OF 1 TO 4 CARBON ATOMS, AND R2 IS A STRAIGHT OR BRANCHED ALKYLIDENE OF 1 TO 4 CARBON ATOMS AND HAL IS SELECTED FROM THE GROUP CONSISTING OF FLUORINE, BROMINE AND CHLORINE, WHICH COMPOUNDS WHICH CONTAIN AT LEAST ONE ASYMMETRIC CARBON ATOM CAN BE IN RACEMIC OR OPTICALLY ACTIVE GORM, AND THEIR PREPARATION WHICH COMPOUNDS HAVE ANALGESIC AND ANTIINFLAMMATORY ACTIVITY.