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    Novel thienobenzazepines as anti-depressants
    1.
    发明授权
    Novel thienobenzazepines as anti-depressants 失效
    新的三苯并噻吩作为抗病毒剂

    公开(公告)号：US3856910A

    公开(公告)日：1974-12-24

    申请号：US40914473

    申请日：1973-10-24

    Applicant: ROUSSEL UCLAF

    Inventor： NEDELEC L ,  GUILLAUME J ,  ALLAIS A

    IPC: C07D495/04 ,  C07D495/20 ,  A61K27/00

    CPC classification number: C07D495/04

    Abstract: Novel 4-(alkylaminoalkyl)-(4H)-thieno-(3,2-b)(f)-benzazepines of the formula
    WHEREIN R1 and R2 are selected from the group consisting of hydrogen, halogen, -CF3, lower alkoxy optionally substituted, lower alkylthio, lower alkyl, optionally substituted sulfonamido, diloweralkylamino and acylamino wherein the acyl is derived from an organic carboxylic acid of one to 18 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl, A is alkylene of two to five carbon atoms, optionally substituted by lower alkyl, B is selected from the group consisting of hydrogen, lower alkyl and arloweralkyl, C is selected from the group consisting of lower alkyl and arloweralkyl and B and C taken together are alkylene of two to six carbon atoms optionally interrupted with one or two heteroatoms, Y is selected from the group consisting of hydrogen, hydroxy, lower alkoxy and lower alkanoyloxy, X is hydrogen and taken together with Y forms a carbon-carbon double bond, Z'' is selected from the group consisting of hydrogen and lower alkyl and Z is selected from the group consisting of hydrogen, lower alkyl and lower alkoxy and taken with Y forms a member of the group consisting of 0, lower alkylenedioxy, loweralkylenedithio and thioloweralkyleneoxy and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressant activity with a large therapeutic index and their preparation and novel intermediates.

    Abstract translation: 式WHEREIN R1和R2的新型4-（烷基氨基烷基） - [4H] - 噻吩并 - [3,2-b] [f] - 苯并氮杂选自氢，卤素，-CF 3，任选取代的低级烷氧基 ，低级烷硫基，低级烷基，任选取代的磺酰氨基，二低级烷基氨基和酰基氨基，其中酰基衍生自1至18个碳原子的有机羧酸，R选自氢和低级烷基，A是两个至 五个碳原子，任选被低级烷基取代，B选自氢，低级烷基和芳基烷基，C选自低级烷基和低级烷基，B和C一起为二至六碳的亚烷基 任选地被一个或两个杂原子中断的原子，Y选自氢，羟基，低级烷氧基和低级烷酰氧基，X是氢并与Y一起形成碳 - 碳双键，Z'选自 由氢和低级烷基组成的组，Z选自氢，低级烷基和低级烷氧基，Y取代为= 0，低级亚烷基二氧基，低级亚烷基二硫和硫代低级亚烷基氧基团的成员， 具有大的治疗指数的抗抑郁活性的有毒的药学上可接受的酸加成盐及其制备方法和新的中间体。

    Tetrahydropyranyl and tetrahydrothiapyranyl phenylacetic acid compounds
    4.
    发明授权
    Tetrahydropyranyl and tetrahydrothiapyranyl phenylacetic acid compounds 失效
    四氢呋喃和四氢萘甲酸苯甲酸化合物

    公开(公告)号：US3772332A

    公开(公告)日：1973-11-13

    申请号：US3772332D

    申请日：1972-04-12

    Applicant: ROUSSEL UCLAF

    Inventor： ALLAIS A ,  MEIER J ,  DUBE J

    IPC: C07D335/02 ,  C07D309/02 ,  C07D309/04 ,  C07D309/06 ,  A61K27/00 ,  C07D65/04

    CPC classification number: C07D309/06 ,  C07D309/04

    Abstract: NOVEL COMPOUNDS OF THE FORMULA

    (2-HAL,4-(R-OOC-Z-)PHENYL)-CH
    WHEREIN X IS SELECTED FROM THE GROUP CONSISTING OF OXYGEN, SULFUR, SO AND SO2, R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ANION OF A NON-TOXIC; THERAPEUTICALLY ACCEPTABLE ORGANIC OR MINERAL BASE AND RESIDUE OF AN ALCOHOL, AN Z IS SELCETED FROM THE GROUP CONSISTING OF -CHR1- AND >C=R2 WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND STRAINGT OR BRANCHED ALKYL OF 1 TO 4 CARBON ATOMS, AND R2 IS A STRAIGHT OR BRANCHED ALKYLIDENE OF 1 TO 4 CARBON ATOMS AND HAL IS SELECTED FROM THE GROUP CONSISTING OF FLUORINE, BROMINE AND CHLORINE, WHICH COMPOUNDS WHICH CONTAIN AT LEAST ONE ASYMMETRIC CARBON ATOM CAN BE IN RACEMIC OR OPTICALLY ACTIVE GORM, AND THEIR PREPARATION WHICH COMPOUNDS HAVE ANALGESIC AND ANTIINFLAMMATORY ACTIVITY.

    Fungicidal 3-amino-4-dihalo pyrazolones
    5.
    发明授权
    Fungicidal 3-amino-4-dihalo pyrazolones 失效
    杀真菌剂3-氨基-4-二氢吡喃酮

    公开(公告)号：US3738987A

    公开(公告)日：1973-06-12

    申请号：US3738987D

    申请日：1971-02-19

    Applicant: ROUSSEL UCLAF

    Inventor： ALLAIS A ,  GIRAULT P

    IPC: C07D231/48 ,  A01N9/22

    CPC classification number: C07D231/48

    Abstract: 3-AMINO-4,4-DIHALO-5-PYRAZOLONES OF THE FORMULA

    1-Y,3-(R-N(-R1)-),4,4-DI(X-),5-(O=)-2-PYRAZOLINE

    WHEREIN X AND X'' ARE SELECTED FROM THE GROUP CONSISTING OF CHLORINE AND BROMINE, Y IS SELECTED FROM THE GROUP CONSISTING OF ALKYL, CYCLOALKYL AND ARYL WHICH MAY BE SUBSTITUTED AND R AND R1 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL, ARYL, CYCLOALKYL AND ARALKYL WHICH POSSESS FUNGICIDAL ACTIVITY.

    Thienobenzazepines
    7.
    发明授权
    Thienobenzazepines 失效
    三苯并噻唑

    公开(公告)号：US3787445A

    公开(公告)日：1974-01-22

    申请号：US3787445D

    申请日：1972-02-28

    Applicant: ROUSSEL UCLAF

    Inventor： NEDELEC L ,  GUILLAUME J ,  ALLAIS A

    IPC: C07D223/16 ,  A61K31/55 ,  C07D333/50 ,  C07D495/04 ,  C07D495/20 ,  A61K27/00 ,  C07D63/18

    CPC classification number: C07D495/04

    Abstract: NOVEL 4-(ALKYAMINOALKYL)-(4H)-THIENO-(3,2-B)(F)BENZAZEPINES OF THE FORMULA

    4-(B-N(-C)-A-),9-X,9-Z'',10-Y,10-Z,R,R1,R2-9,10-DIHYDRO-

    4H-THIENO(3,2-B)-4-BENZAZEPINE

    WHEREIN R1 AND R2 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGE, HALOGEN, -CF3, LOWER ALOXY OPTIONALLY SUBSTITUTED, LOWER ALKYLTHIO, LOWER ALKYL, OPTIONALLY SUBSTITUTED SULFONAMIDE, DILOWERALKYLAMINO AND ACYLAMINO WHEREIN THE ACYL IS DERIVED FROM AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS, R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL, A IS ALKYLENE OF 2 TO 5 CARBON ATOMS, OPTIONALLY SUBSTITUTED BY LOWER ALKYL, B IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL AND ARLOWERALKYL, C IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL AND ARLOWERALKYL AND B AND C TAKEN TOGETHER ARE ALKYLENE OR 2 TO 6 CARBON TOMS OPTIONALLY INTERRUPTED WITH 1 OR 2 HETEROATOMS, Y IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HYDROXY, LOWER ALKOXY AND LOWER ALKANOYLOXY, X IS HYDROGEN AND TAKEN TOGETHER WITH Y FORMS A CARBON-CARBON DOUBLE BOND, Z'' IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL AND Z IS SELECTED FROM THE GROUP CONSISTING OF HYDROGN, LOWER ALKYL AND LOWER ALKOXY AND TAKEN WITH Y FORMS A MEMBER OF THE GROUP CONSISTING OF =O, LOWER ALKYLENEDIOXY, LOWER ALKYLENEDITHIO AND THIOLOWERALKYLENEOXY AND THEIR NON-TOXIC, PHARMACEUTICALY ACCEPTABLE ACID ADDITION SALTS HAVING ANTIDEPRESSANT ACTIVITY WITH A LARGE THERAPEUTIC INDEX AND THEIR PREPARATION AND NOVEL INTERMEDIATES.

    Benzazepines
    8.
    发明授权
    Benzazepines 失效
    BENZAZEPINES

    公开(公告)号：US3767676A

    公开(公告)日：1973-10-23

    申请号：US3767676D

    申请日：1972-02-28

    Applicant: ROUSSEL UCLAF

    Inventor： NEDELEC L ,  GUILLAUME J ,  ALLAIS A

    IPC: C07D223/16 ,  C07C205/56 ,  C07D333/28 ,  C07D333/50 ,  C07D333/80 ,  C07D495/00 ,  C07D495/04 ,  C07D495/20 ,  A61K27/00 ,  C07D63/18

    CPC classification number: C07D495/04 ,  C07C205/56 ,  C07D333/28

    Abstract: NOVEL 9,10-DIHYDRO-(4H)-THIENO-(3,2-B) (F)-BENZAZEPINES OF THE FORMULA

    10-A,10-A'',R,R1,R2-9,10-DIHYDRO-4H-THIENO(3,2-B)(F)-

    BENZAZEPINE

    WHEREIN A AND A'' ARE INDIVIDUALLY SELECTED FROM THE GROUP CONSISTING OF LOWER ALKOXY AND LOWR ALKYLTHIO AND TAKEN TOGETHER ARE SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYLENEDIOXY, LOWWE ALKYLENEDITHIO AND THIOLOWERALKYLENEOXY, R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL AND R1 AND R2 ARE INDIVIDUALLY SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, -CF3, OPTIONALLY SUBSTITUTED LOWER ALKOXY, LOWER ALKYLTHIO, OPTIONALLY SUBSTITUTED SULFONAMIDO, DILOWERALKYL AMINO, AND ACYLAMINO WHERE THE ACYL IS DERIVED FROM AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS WHICH ARE INTERMEDIATES FOR 4-(ALKYLAMINOALKYL)-(4H)-THIENO(3,2-B) (F)-BENZAZEPINES HAVING ANTIDEPRESSANT ACTIVITY AND THE PROCESS FOR THE THEIR PREPARATION AND NOVEL INTERMEDIATES.

    Certain barbituric acid derivatives
    9.
    发明授权
    Certain barbituric acid derivatives 失效
    某些巴比妥酸衍生物

    公开(公告)号：US3749723A

    公开(公告)日：1973-07-31

    申请号：US3749723D

    申请日：1971-12-14

    Applicant: ROUSSEL UCLAF

    Inventor： ALLAIS A ,  PETERFALVI M

    IPC: C07D239/62 ,  C07D51/20

    CPC classification number: C07D239/62

    Abstract: 2,4,6-TRI(O=),5-(3-(R2-OOC-NH-)PHENYL),5-R1-PERHYDRO-

    PYRIMIDINE

    IN WHICH R1 AND R2 ARE IDENTICAL OR DIFFERENT AND REPRESENT AN ALKYL RADICAL CARRYING FROM 1 TO 6 CARBON ATOMS, AND THEIR ORGANIC OR MINERAL BASE SALTS, AND THEIR USE AS ANTI-CONVULSANT AGENTS.
    NOVEL MALONYUREAS OF THE FORMULA

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