公开(公告)号：US09657334B2

公开(公告)日：2017-05-23

申请号：US14305499

申请日：2014-06-16

申请人： Rutgers, The State University of New Jersey ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6876 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2535/131 ,  C12Q2531/113

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

公开(公告)号：US20170356034A1

公开(公告)日：2017-12-14

申请号：US15601450

申请日：2017-05-22

申请人： Rutgers, The State University of New Jersey ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6876 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2535/131 ,  C12Q2531/113

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

公开(公告)号：US20150125856A1

公开(公告)日：2015-05-07

申请号：US14305499

申请日：2014-06-16

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6876 ,  C12Q1/6895 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2535/131 ,  C12Q2531/113

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

摘要翻译： 核酸扩增测定用于两个短切片真菌基因FKS1的突变。 已经显示这些靶序列中的突变与对棘白菌素类药物的抗性相关。 测定可以包括通过测序或通过标记的杂交探针进行检测。 另外，用于进行这种测定的引物，探针和试剂盒。

公开(公告)号：US10934577B2

公开(公告)日：2021-03-02

申请号：US15601450

申请日：2017-05-22

申请人： Rutgers, The State University of New Jersey ,  Merck & Co., Inc.

发明人： David S. Perlin ,  Steven Park ,  Cameron M. Douglas ,  Jennifer N. Kahn ,  Stephen A. Parent ,  Rosemarie Kelly

IPC分类号： C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6895 ,  C12Q1/6876 ,  C12Q1/6844

摘要： Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.