摘要:
The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
摘要:
There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要:
Compound of formula (I): and salts and solvates thereof, a process for its preparation, pharmaceutical formulations containing it and its use in therapy.
摘要:
Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.
摘要:
The invention to which this application relates is the provision of a method and apparatus which allows the graphical representation of organizations and the interpretation of business structures and in particular allows the representation of variants within said business structures and allows these variants to be dealt with in an organized and more efficient manner than is conventionally possible. Thus, several different variants of an organizational model can be created and compared. Typically all of the variants include the components, interfaces, references and elements of the original organizational model.
摘要:
A method of fabricating a structure comprising the steps of: providing an electrical conductor; providing a layer of a flexible insulating material on the electrical conductor, the material comprising: a first organo-alkoxide 1RxSi(O1R′)4-x and a second organo-alkoxide 2RxSi(O2R′)4-x, where 1R is a non-hydrolysable organic moiety thermally stable to a temperature of at least 150° C., 2R is a non-hydrolysable organic moiety containing a functional group that can react with another like functional group to form an organic polymer, 1R′ and 2R′ are alkyl radicals and x is an integer from 0 to 3; and an inorganic filler material.
摘要:
A method of fabricating a structure comprising the steps of: providing an electrical conductor; providing a layer of a flexible insulating material on the electrical conductor, the material comprising: a first organo-alkoxide 1RxSi(O1R′)4-x and a second organo-alkoxide 2RxSi(O2R′)4-x, where 1R is a non-hydrolysable organic moiety thermally stable to a temperature of at least 150° C., 2R is a non-hydrolysable organic moiety containing a functional group that can react with another like functional group to form an organic polymer, 1R′ and 2R′ are alkyl radicals and x is an integer from 0 to 3; and an inorganic filler material.
摘要:
The invention to which this application relates is the provision of a method and apparatus which allows the graphical representation of organisations and the interpretation of business structures and in particular allows the representation of variants within said business structures and allows these variants to be dealt with in an organised and more efficient manner than is conventionally possible. Thus, several different variants of an organisational model can be created and compared. Typically all of the variants include the components, interfaces, references and elements of the original organisational model.
摘要:
The invention relates to a method and apparatus for developing a business and/or technical architecture of an organization. The invention includes the ability to identify and create specific elements which are required for a specific architecture framework and putting these specific elements together within a set of models or views, and allowing access through a visual representation of the architecture framework, along with an apparatus comprising the technical features to accommodate the method allow selection of one or a number of elements to generate further visualizations and/or links to further database or operating tools while allowing interaction with know organizational representations.