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    Aminoindazole derivatives active as kinase inhibitors
    1.
    发明授权
    Aminoindazole derivatives active as kinase inhibitors 有权
    作为激酶抑制剂活性的氨基吲唑衍生物

    公开(公告)号：US07511136B2

    公开(公告)日：2009-03-31

    申请号：US10490189

    申请日：2002-09-19

    申请人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

    发明人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

    IPC分类号： C07D413/00 ,  C07D231/00

    CPC分类号： C07D231/56 ,  C07D403/04 ,  C07D403/12

    摘要： Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

    摘要翻译： 公开了3-氨基吲唑衍生物或其药学上可接受的盐以及包含它们的药物组合物的化合物; 这些化合物或组合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。

    2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents
    5.
    发明授权
    2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents 失效
    2-氨基 - 噻唑衍生物，其制备方法及其作为抗肿瘤剂的用途

    公开(公告)号：US07037929B1

    公开(公告)日：2006-05-02

    申请号：US09807962

    申请日：1999-10-27

    申请人： Paolo Pevarello ,  Raffaella Amici ,  Gabriella Traquandi ,  Manuela Villa ,  Anna Vulpetti ,  Antonella Isacchi

    发明人： Paolo Pevarello ,  Raffaella Amici ,  Gabriella Traquandi ,  Manuela Villa ,  Anna Vulpetti ,  Antonella Isacchi

    IPC分类号： A61K31/426 ,  A61K31/495 ,  C07D277/20 ,  C07D413/02 ,  C07D417/02

    CPC分类号： C07D417/12 ,  A61K31/426 ,  A61K31/427 ,  C07D277/46

    摘要： Compounds which are 2-amino-1,3-thiazole derivatives of formula (I) wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group, optionally further substituted, selected from i) straight or branched C1–C8 alkyl, C2–C6 alkenyl or C2–C6 alkynyl; ii) C3–C6 cycloalkyl; iii) aryl or arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; R1 is an optionally further substituted group selected from: i) straight or branched C1–C8 alkyl or C2–C6 alkenyl; ii) 3 to 6 membered carbocycle or 5 to 7 membered heterocycle ring; iii) aryl or arylcarbonyl; iv) arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; v) arylalkenyl with from 2 to 6 carbon atoms within the straight or branched alkenyl chain; vi) an optionally protected amino acid residue; or a pharmaceutically acceptable salt thereof; are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.

    摘要翻译： 作为式（I）的2-氨基-1,3-噻唑衍生物的化合物，其中R是卤素原子，硝基，任选取代的氨基，或者是任选进一步取代的选自i）直链或 支链C 1 -C 8烷基，C 2 -C 6亚烯基或C 2 -C 6亚烷基， C 6 -C 6炔基; ii）C 3 -C 6环烷基; iii）在直链或支链烷基链中具有1至8个碳原子的芳基或芳基烷基; R 1是任选进一步取代的基团，其选自：i）直链或支链C 1 -C 8烷基或C 2 - / C 1 -C 6链烯基; ii）3至6元碳环或5至7元杂环; iii）芳基或芳基羰基; iv）在直链或支链烷基链中具有1至8个碳原子的芳基烷基; v）直链或支链烯基链中具有2至6个碳原子的芳基烯基; vi）任选保护的氨基酸残基; 或其药学上可接受的盐; 可用于治疗与改变的细胞依赖性激酶活性相关的细胞增殖性疾病。