公开(公告)号：US20110112042A1

公开(公告)日：2011-05-12

申请号：US12920927

申请日：2009-03-03

申请人： Rakesh Maurya ,  Preeti Rawat ,  Kunal Sharan ,  Jawed Akhtar Siddiqui ,  Gaurav Swarnkar ,  Geetanjali Mishra ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Kamal Ram Arya ,  Naibedya Chattopadhyay

发明人： Rakesh Maurya ,  Preeti Rawat ,  Kunal Sharan ,  Jawed Akhtar Siddiqui ,  Gaurav Swarnkar ,  Geetanjali Mishra ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Kamal Ram Arya ,  Naibedya Chattopadhyay

IPC分类号： A61K31/7048 ,  C07H7/06 ,  C07H1/08 ,  A61P19/08

CPC分类号： C07H7/06 ,  C07D405/04

摘要： The present invention provides a flavonol compound and a bioactive extract/fraction from Ulmus wallichiana useful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R1═R2═0H K012: R1═R2═OH, 2,3 double bond K068: R1═R2═H KIOOi R1═OH, R2═H mula 2 Wherein the marker compounds K012, K058, K068, K100 ranges 6.7-12%, 1.7-4.5%, 0.6-1.2%, 1.7-4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route.

摘要翻译： 本发明提供了一种黄酮醇化合物和可用于治疗或预防或治疗骨骼疾病的来自榆树的生物活性提取物/部分。 所述提取物/级分包含通式2的标记化合物，K058：R1 = R2 = 0H，K012：R1 = R2 = OH，2,3双键，K068：R1 = R2 = H，KIOO，R1 = OH，R2 = H， 标记化合物K012，K058，K068，K100分别在酒精提取物中分别为6.7-12％，1.7-4.5％，0.6-1.2％，1.7-4.5％及其提取方法。 根据本发明的另一方面，提供了包含所述化合物的药物组合物。 本发明还提供了通过口服，静脉内，皮下，腹膜内或肌肉内途径施用药物组合物来治疗骨病的方法。

公开(公告)号：US08669232B2

公开(公告)日：2014-03-11

申请号：US12920927

申请日：2009-03-03

申请人： Rakesh Maurya ,  Preeti Rawat ,  Kunal Sharan ,  Jawed Akhtar Siddiqui ,  Gaurav Swarnkar ,  Geetanjali Mishra ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Kamal Ram Arya ,  Naibedya Chattopadhyay

发明人： Rakesh Maurya ,  Preeti Rawat ,  Kunal Sharan ,  Jawed Akhtar Siddiqui ,  Gaurav Swarnkar ,  Geetanjali Mishra ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Kamal Ram Arya ,  Naibedya Chattopadhyay

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7042 ,  C07H1/08

CPC分类号： C07H7/06 ,  C07D405/04

摘要： The present invention provides a flavonol compound and a bioactive extract/fraction from Ulmus wallichiana useful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R1═R2═OH K012: R1═R2═OH, 2,3 double bond K068: R1═R2═H KIOOi R1═OH, R2═H mula 2 Wherein the marker compounds K012, K058, K068, K1OO ranges 6.7-12%, 1.7-4.5%, 0.6-1.2%, 1.7-4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route.

摘要翻译： 本发明提供了一种黄酮醇化合物和可用于治疗或预防或治疗骨骼疾病的来自榆树的生物活性提取物/部分。 所述提取物/级分包含通式2的标记化合物，K058：R1 = R2 = OHK012：R1 = R2 = OH，2,3双键K068：R1 = R2 = H KIOOi R1 = OH，R2 = Hmula 2其中 标记化合物K012，K058，K068，K100分别在酒精提取物中分别为6.7-12％，1.7-4.5％，0.6-1.2％，1.7-4.5％及其提取方法。 根据本发明的另一方面，提供了包含所述化合物的药物组合物。 本发明还提供了通过口服，静脉内，皮下，腹膜内或肌肉内途径施用药物组合物来治疗骨病的方法。

公开(公告)号：US20140079834A1

公开(公告)日：2014-03-20

申请号：US14113561

申请日：2012-04-25

申请人： Rakesh Maurya ,  Preety Dixit ,  Ritu Trivedi ,  Vikram Khedgikar ,  Jyoti Gautam ,  Avinash Kumar ,  Divya Singh ,  Sheelendra Pratap Singh ,  (none) Wahajuddin ,  Girish Kumar Jain ,  Naibedya Chattopadhyay

发明人： Rakesh Maurya ,  Preety Dixit ,  Ritu Trivedi ,  Vikram Khedgikar ,  Jyoti Gautam ,  Avinash Kumar ,  Divya Singh ,  Sheelendra Pratap Singh ,  (none) Wahajuddin ,  Girish Kumar Jain ,  Naibedya Chattopadhyay

IPC分类号： A61K31/7048 ,  A61K31/352 ,  A61K36/48

CPC分类号： A61K31/7048 ,  A61K31/352 ,  A61K36/48 ,  C07D311/36 ,  C07H17/07

摘要： The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, from Dalbergia sissoo plant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.

摘要翻译： 本发明涉及用于预防或治疗与骨骼健康相关的疾病的生物活性级分和来自枸杞子的化合物。 本发明涉及药物组合物领域，其提供新的植物提取物，其级分和从天然来源分离的纯化合物，其可用于预防和/或治疗与雌激素依赖性或独立疾病或综合征或病症相关的各种医学适应症 优选地在预防或治疗在人和动物中引起的雌激素依赖性或独立性疾病或综合征或障碍，以及在人和动物的骨骼生长和健康期间达到峰值骨量。 特别地，本发明还涉及从家蚕豆科的Dalbergia sissoo植物制备生物活性提取物，级分和分离纯化合物的方法，它们的药学上可接受的盐和本发明主要方面的组合物。

公开(公告)号：US10292994B2

公开(公告)日：2019-05-21

申请号：US14113561

申请日：2012-04-25

申请人： Rakesh Maurya ,  Preety Dixit ,  Ritu Trivedi ,  Vikram Khedgikar ,  Jyoti Gautam ,  Avinash Kumar ,  Divya Singh ,  Shelendra Pratap Singh ,  Wahajuddin ,  Girish Kumar Jain ,  Naibedya Chattopadhyay

发明人： Rakesh Maurya ,  Preety Dixit ,  Ritu Trivedi ,  Vikram Khedgikar ,  Jyoti Gautam ,  Avinash Kumar ,  Divya Singh ,  Shelendra Pratap Singh ,  Wahajuddin ,  Girish Kumar Jain ,  Naibedya Chattopadhyay

IPC分类号： A61K31/7048 ,  C07D311/36 ,  C07H17/07 ,  A61K31/352 ,  A61K36/48

摘要： The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, from Dalbergia sissoo plant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.

公开(公告)号：US06913772B2

公开(公告)日：2005-07-05

申请号：US10735437

申请日：2003-12-11

申请人： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishan Kapahi

发明人： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishan Kapahi

IPC分类号： A01N25/00 ,  A01N27/00 ,  A01N65/00 ,  A61K31/4745 ,  A61K31/70 ,  A61K36/27 ,  A61K35/78

CPC分类号： A61K36/27 ,  Y10S514/885 ,  Y10S514/893 ,  Y10S514/894

摘要： The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of producing said composition and also a method of treating a subject using said composition.

摘要翻译： 本发明涉及一种可用于肝保护的组合物，所述组合物包含植物Cryptolepis Buchanani的极性提取物和/或所述提取物的级分，和任选的药学上可接受的添加剂和制备所述组合物的方法，以及使用 所说的组合。

公开(公告)号：US06562791B1

公开(公告)日：2003-05-13

申请号：US10112229

申请日：2002-03-29

申请人： Rakesh Maurya ,  Deepa Singh ,  Asha Bhagat ,  Om Parkash Gupta ,  Sukhdev Swami Handa

发明人： Rakesh Maurya ,  Deepa Singh ,  Asha Bhagat ,  Om Parkash Gupta ,  Sukhdev Swami Handa

IPC分类号： A61K317042

CPC分类号： C07H7/06 ,  Y10S514/866

摘要： A novel glucopyranoside, 6-hydroxy-2-p-hydroxybenzylbenzofuran-7-C-&bgr;-D-glucopyranoside of the formula 1 isolated from Pterocarpus marsupium and to a process for the isolation thereof is disclosed. The invention also relates to a pharmaceutical composition containing 6-hydroxy-2-p-hydroxybenzylbenzofuran-7-C-&bgr;-D-glucopyranoside and to method for the treatment of diabetes using said compound.

摘要翻译： 公开了一种新颖的吡喃葡萄糖苷，由Pterocarpus marsupium分离的式1的6-羟基-2-对羟基苄基苯并呋喃-7-C-β-D-吡喃葡萄糖苷及其分离方法。 本发明还涉及含有6-羟基-2-对羟基苄基苯并呋喃-7-C-β-D-吡喃葡萄糖苷的药物组合物和使用所述化合物治疗糖尿病的方法。

公开(公告)号：US06548086B1

公开(公告)日：2003-04-15

申请号：US10024401

申请日：2001-12-18

申请人： Rakesh Maurya ,  Anpurna Kaul ,  Sarang Bani ,  Usha Zutshi ,  Anamika Khajuria ,  Ajit Kumar Saxena ,  Lila Ram Manahas ,  Ashwani Kumar ,  Bal Krishnan Kapahi ,  Om Parkash Suri ,  Gulam Nabi Qazi

发明人： Rakesh Maurya ,  Anpurna Kaul ,  Sarang Bani ,  Usha Zutshi ,  Anamika Khajuria ,  Ajit Kumar Saxena ,  Lila Ram Manahas ,  Ashwani Kumar ,  Bal Krishnan Kapahi ,  Om Parkash Suri ,  Gulam Nabi Qazi

IPC分类号： A61K3578

CPC分类号： A61K31/704 ,  A61K31/585 ,  A61K36/27

摘要： Pharmaceutical composition and a method useful for treating immunodeficiency in animals or human beings, said composition comprising effective amount of the extract obtained from any part of plant Cryptolepis buchanani, either as such or its individual constituents singly or in composition with each other, optionally associated with pharmaceutically acceptable additives.

摘要翻译： 药物组合物和可用于治疗动物或人类免疫缺陷的方法，所述组合物包含有效量的从植物Cryptolepis buchanani的任何部分获得的提取物，或其单独或组成彼此单独或组成的任选的与 药学上可接受的添加剂。

公开(公告)号：US06977294B2

公开(公告)日：2005-12-20

申请号：US10099292

申请日：2002-03-13

申请人： Deepak Mundkinajeddu ,  Lila Ram Manahas ,  Rakesh Maurya ,  Sukhdev Swami Handa

发明人： Deepak Mundkinajeddu ,  Lila Ram Manahas ,  Rakesh Maurya ,  Sukhdev Swami Handa

IPC分类号： A61K31/7048 ,  A61K36/18 ,  A61P5/20 ,  A61P19/10 ,  C07H1/08 ,  C07H17/07 ,  C07H17/00 ,  A61K35/78

CPC分类号： C07H17/07 ,  C07H1/08

摘要： The present invention relates to a process of isolation of bioactive eupalitin (3-O-O-D-galactopyranoside) of formula 1 possessing anti-osteoporosis activity by extraction of powdered leaves of Boerhaavia diffusa, with better yield:

摘要翻译： 本发明涉及通过提取Boerhaavia diffusa的粉末叶分离具有抗骨质疏松活性的式1的生物活性eupalitin（3-O-O-吡喃半乳糖苷）的方法，其产率更高：

公开(公告)号：US06777392B2

公开(公告)日：2004-08-17

申请号：US10113204

申请日：2002-03-28

申请人： Rakesh Maurya ,  Sukhdev Swami Handa ,  Rajinder Singh

发明人： Rakesh Maurya ,  Sukhdev Swami Handa ,  Rajinder Singh

IPC分类号： A01K317042

CPC分类号： C07H17/07

摘要： The present invention relates to a novel compound 8-(C-&bgr;-D-glucopyranosyl)-7,3′,4′-trihydroxyflavone, isolated from Pterocarpus marsupium useful in the treatment of diabetes. The present invention also relates to a method for the preparation of the compound and to the uses thereof.

摘要翻译： 本发明涉及从用于治疗糖尿病的仙人掌分离的新型化合物8-（C-β-D-吡喃葡萄糖基）-7,3'，4'-三羟基黄酮。 本发明还涉及一种制备该化合物的方法及其用途。

公开(公告)号：US06617313B1

公开(公告)日：2003-09-09

申请号：US10099293

申请日：2002-03-13

申请人： Rakesh Maurya ,  Sukhdev Swami Handa ,  Rajinder Singh

发明人： Rakesh Maurya ,  Sukhdev Swami Handa ,  Rajinder Singh

IPC分类号： A61K3170

CPC分类号： C07H7/06 ,  A61K31/70 ,  C07H1/08 ,  Y10S514/866

摘要： A novel glucopyranoside, 2,6-dihydroxy-2-(P-hydroxybenzyl)-3(2H) benzofuran-7-C-&bgr;-D-glucopyranoside of the formula 1 isolated from Pterocarpus marsupium and to a process for the isolation thereof is disclosed. The invention also relates to a pharmaceutical composition containing 2,6-dihydroxy-2-(P-hydroxybenzyl)-3(2H)benzofuran-7-C-&bgr;-D-glucopyranoside and to method for the treatment of diabetes using said compound.

摘要翻译： 公开了一种从蕨类植物中分离得到的新颖的吡喃葡萄糖苷，2,6-二羟基-2-（P-羟基苄基）-3（2H）苯并呋喃-7-C-β-D-吡喃葡萄糖苷及其分离方法 。 本发明还涉及含有2,6-二羟基-2-（P-羟基苄基）-3（2H）苯并呋喃-7-C-β-D-吡喃葡萄糖苷的药物组合物和使用所述化合物治疗糖尿病的方法。