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公开(公告)号:US20050266024A1
公开(公告)日:2005-12-01
申请号:US10507928
申请日:2003-03-19
申请人: Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
发明人: Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
IPC分类号: C12N15/09 , A61K9/06 , A61K9/18 , A61K31/4745 , A61K39/00 , A61K39/21 , A61K39/39 , A61K45/06 , A61K48/00 , A61P31/18 , A61P37/04 , C07D471/04 , C07K14/16
CPC分类号: C07K14/005 , A61K31/4745 , A61K39/12 , A61K39/21 , A61K39/39 , A61K45/06 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55511 , A61K2039/55555 , C12N2730/10134 , C12N2740/16222 , C12N2740/16234 , A61K2300/00
摘要: The relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions. The invention in particular relates to DNA vaccines that are useful in the prophylaxis and treatment of HIV infections, more particularly when administered by particle mediated delivery.
摘要翻译: 涉及某些佐剂组合物,以及使用这种组合物的疫苗和/或核酸免疫策略。 本发明特别涉及可用于预防和治疗HIV感染的DNA疫苗,特别是当通过颗粒介导的递送施用时。
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公开(公告)号:US20050256070A1
公开(公告)日:2005-11-17
申请号:US11029465
申请日:2005-01-06
申请人: Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
发明人: Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
CPC分类号: C07K14/005 , A61K31/4745 , A61K39/12 , A61K39/21 , A61K39/39 , A61K45/06 , A61K2039/53 , A61K2039/54 , A61K2039/55511 , A61K2039/55555 , A61K2039/57 , C12N2710/16634 , C12N2740/16222 , C12N2740/16234 , A61K2300/00
摘要: The present invention relates to the fields of vaccines, vaccine adjuvants, molecular biology and immunology, and generally adjuvants and nucleic acid immunization techniques. More specifically, the invention relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions. The invention in particular relates to DNA vaccines that are useful in the prophylaxis and treatment of HIV infections, more particularly when administered by particle mediated delivery.
摘要翻译: 本发明涉及疫苗,疫苗佐剂,分子生物学和免疫学领域,通常是佐剂和核酸免疫技术。 更具体地,本发明涉及某些佐剂组合物,以及使用这种组合物的疫苗和/或核酸免疫策略。 本发明特别涉及可用于预防和治疗HIV感染的DNA疫苗,特别是当通过颗粒介导的递送施用时。
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公开(公告)号:US20050143284A1
公开(公告)日:2005-06-30
申请号:US10507055
申请日:2003-03-18
申请人: Lindy Thomsen , John Tite
发明人: Lindy Thomsen , John Tite
IPC分类号: A61K9/00 , A61K39/39 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/08 , A01N37/18 , A61K38/00
CPC分类号: A61K39/39 , A61K2039/53 , A61K2039/55511 , Y02A50/412
摘要: The present invention relates to improvements in DNA vaccination and in particular, methods of vaccinating a mammal against disease states, and to the use of imidazo[4,5, -c]-4-amine derivative adjuvants in the manufacture of medicaments for boosting previously vaccinated individuals.
摘要翻译: 本发明涉及DNA疫苗接种的改进,特别是涉及哺乳动物接种疾病状态的方法,以及咪唑并[4,5,-c] -4-胺衍生物佐剂在制造用于先前增强的药物中的用途 接种个体
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公开(公告)号:US20070248614A1
公开(公告)日:2007-10-25
申请号:US11764814
申请日:2007-06-19
申请人: Lindy Thomsen , John Tite , Peter Topley
发明人: Lindy Thomsen , John Tite , Peter Topley
CPC分类号: C07D215/22 , A61K39/39 , A61K2039/53 , A61K2039/55511 , C07D215/42 , Y02A50/41 , Y02A50/412 , Y02A50/423
摘要: The present invention relates to the use of a 1H-imidazo[4,5-c]quinolin-4-amine derivative as an adjuvant for use with nucleic acid vaccination.
摘要翻译: 本发明涉及1 H-咪唑并[4,5-c]喹啉-4-胺衍生物作为佐剂用于核酸疫苗接种的用途。
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公开(公告)号:US20050054726A1
公开(公告)日:2005-03-10
申请号:US10491843
申请日:2002-09-26
申请人: Lindy Thomsen
发明人: Lindy Thomsen
IPC分类号: A61K9/14 , A61K31/155 , A61K31/198 , A61K39/00 , A61K39/39 , A61K45/00 , A61K47/02 , A61K48/00 , A61P37/04 , A61P43/00 , A61K31/275
CPC分类号: A61K39/39
摘要: The present invention relates to the use of inducible nitric oxide synthase (iNOS) inhibitors as vaccine adjuvants, and in a preferred aspect of the present invention they are used for adjuvanting nucleic acid vaccines. The present invention further provides pharmaceutical compositions comprising an antigen and the inhibitor.
摘要翻译: 本发明涉及可诱导型一氧化氮合酶(iNOS)抑制剂作为疫苗佐剂的用途,在本发明的优选方面,它们用于佐剂核酸疫苗。 本发明还提供包含抗原和抑制剂的药物组合物。
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